protein

ENDOG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections
0Hypotheses
0Analyses
50Outgoing
16Incoming

Summary

ENDOG is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolENDOG
Full NameEndonuclease G, Mitochondrial
AliasesEndonuclease G
Chromosome9q34.11
FunctionENDOG (Endonuclease G) is a mitochondrial nuclease that plays important roles in both mitochondrial DNA maintenance and apoptosis.
Primary Expressionmost tissues, with high expression in tissues containing high numbers of mitochondria
Subcellular Localization, linking it to stress-response kinase cascades including JNK and p38 MAPK pathways. Additionally, ENDOG participates in
Molecular Weight30 kDa
Amino Acids27 aa
PathwaysAkt, Apoptosis, Autophagy, Mitophagy, Mtor
UniProt ID[O95071](https://www.uniprot.org/uniprot/O95071)
Ensembl IDENSG00000167136
OMIM601060
GeneCardsENDOG
Human Protein AtlasENDOG
Associated Diseasesneurodegeneration
InteractionsBIP, TSC2, EIF2AK3, GSK3B, ERN1, HSPA5
KG Connections71 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

ENDOG

gene · 655 words

Parthanatos in Neurodegeneration

mechanism · 6619 words

Mitochondria in Neurodegeneration

mechanism · 3404 words

Apoptosis in Neurodegeneration

entity · 1020 words

CDKN2B

gene · 972 words

ENDOG Protein (Endonuclease G)

protein · 693 words

Pathway Diagram

graph TD
    ENDOG["<b>ENDOG</b>"]
    Als{"Als"}
    ENDOG -->|"activates"| Als
    MTORC1["MTORC1"]
    ENDOG -->|"activates"| MTORC1
    BIP["BIP"]
    ENDOG -->|"activates"| BIP
    IRE1A["IRE1A"]
    ENDOG -->|"activates"| IRE1A
    APOPTOSIS["APOPTOSIS"]
    ENDOG -->|"activates"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    ENDOG -->|"activates"| AUTOPHAGY
    TSC2["TSC2"]
    ENDOG -->|"activates"| TSC2
    EIF2AK3["EIF2AK3"]
    ENDOG -->|"activates"| EIF2AK3
    GSK3B["GSK3B"]
    ENDOG -->|"activates"| GSK3B
    ERN1["ERN1"]
    ENDOG -->|"activates"| ERN1
    HSPA5["HSPA5"]
    ENDOG -->|"activates"| HSPA5
    ACETYL_COA["ACETYL-COA"]
    ENDOG -->|"activates"| ACETYL_COA
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| ENDOG
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| ENDOG
    YWHAG["YWHAG"]
    YWHAG -->|"activates"| ENDOG
    RICTOR["RICTOR"]
    RICTOR -->|"activates"| ENDOG
    AKT["AKT"]
    AKT -->|"activates"| ENDOG
    style ENDOG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

TargetRelationTypeStr
Alsactivatesdisease0.65
BIPactivatesgene0.60
TSC2activatesgene0.60
EIF2AK3activatesgene0.60
GSK3Bactivatesgene0.60

Incoming (16)

SourceRelationTypeStr
PIK3C3activatesgene0.60
YWHAGactivatesgene0.60
RICTORactivatesgene0.60
AKTactivatesgene0.60
ERN1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found