concept

DIMETHYL FUMARATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIMETHYL FUMARATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

3Analyses

50Outgoing

18Incoming

0Experiments

4Debates

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💡 Concept Info

Name	DIMETHYL FUMARATE
Key Genes/Proteins	APP, CGAS
Related Diseases	ACETYLCHOLINE, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, AUTOPHAGY
Related Pathways	CGAS-STING PATHWAY

Pathway Diagram

graph TD
    DIMETHYL_FUMARATE["DIMETHYL FUMARATE"]
    DIMETHYL_FUMARATE -->|"activates"| NFE2L2["NFE2L2"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Impairment["Cognitive Impairment"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Dysfunction["Cognitive Dysfunction"]
    DIMETHYL_FUMARATE -->|"modulates"| ASTROCYTES["ASTROCYTES"]
    DIMETHYL_FUMARATE -->|"inhibits"| STAT3["STAT3"]
    DIMETHYL_FUMARATE -->|"treats"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    DIMETHYL_FUMARATE -->|"activates"| NRF2_PATHWAY["NRF2 PATHWAY"]
    DIMETHYL_FUMARATE -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ASTROCYTES -->|"activates"| DIMETHYL_FUMARATE
    APP["APP"] -->|"activates"| DIMETHYL_FUMARATE

Outgoing (113)

Target	Relation	Type	Str
NRF2 activation	activates	pathway	0.90
NRF2	activates	protein	0.90
NFE2L2	activates	gene	0.90
Cognitive Dysfunction	treats	phenotype	0.88
Cognitive Impairment	treats	phenotype	0.88
ASTROCYTES	modulates	cell_type	0.85
STAT3	inhibits	gene	0.85
ALZHEIMER'S DISEASE	treats	disease	0.82
Ferroptosis	protects_against	mechanism	0.70
Alzheimer disease	therapeutic_target_for	disease	0.70
Alzheimer's disease	therapeutic_target_for	disease	0.70
LC3	activates	gene	0.70
PINK1	activates	gene	0.70
AUTOPHAGY	treats	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
NRF2 PATHWAY	activates	pathway	0.65
CGAS-STING PATHWAY	activates	pathway	0.65
INFLAMMATION	treats	phenotype	0.65
NRF2	regulates	gene	0.65
NECROPTOSIS	inhibits	phenotype	0.65
MULTIPLE SCLEROSIS	interacts_with	disease	0.65
MULTIPLE SCLEROSIS	treats	disease	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
NRF2	associated_with	gene	0.65
PINK1	treats	gene	0.60
LC3	protects_against	gene	0.60
STING	activates	gene	0.60
cGAS-STING	modulates	pathway	0.60
CD8	activates	gene	0.60
STING	interacts_with	gene	0.60
CD8	interacts_with	gene	0.60
RNA	treats	gene	0.60
TH	treats	gene	0.60
BNIP3	treats	gene	0.60
LC3	treats	gene	0.60
NLR	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
GFP	regulates	gene	0.60
GFP	activates	gene	0.60
NLR	activates	gene	0.60
MAP1LC3	activates	gene	0.60
CALCOCO2	activates	gene	0.60
GAPDH	activates	gene	0.60
PTEN	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
CASP3	activates	gene	0.60
mitochondrial dynamics	modulates	pathway	0.60
HTT	regulates	gene	0.60

Incoming (18)

Source	Relation	Type	Str
34477330	enhances	paper	0.90
34477330	suppresses	paper	0.90
34477330	was safe and well-tolerated in	paper	0.90
34477330	showed lack of	paper	0.90
34477330	was	paper	0.90
34477330	showed	paper	0.90
34477330	did not significantly improve	paper	0.90
34477330	was associated with reduced	paper	0.60
34477330	enhances and suppresses	paper	0.60
CGAS-STING PATHWAY	associated_with	pathway	0.50
ALZHEIMER	associated_with	disease	0.45
APP	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.35
ASTROCYTES	activates	cell_type	0.35
APP	activates	gene	0.35