UCP2

Understanding Entity Pages

This page aggregates everything SciDEX knows about UCP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

UCP2 is a mitochondrial uncoupling protein that regulates proton leak, ROS production, and energy metabolism. It has complex roles in neurodegeneration with both protective and potentially detrimental effects in Alzheimer's and Parkinson's disease.

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graph TD
    UCP2["<b>UCP2</b>"]
    Als{"Als"}
    UCP2 -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    UCP2 -->|"regulates"| Cardiac
    Ms{"Ms"}
    UCP2 -->|"regulates"| Ms
    Ischemia{"Ischemia"}
    UCP2 -->|"regulates"| Ischemia
    Obesity{"Obesity"}
    UCP2 -->|"activates"| Obesity
    Inflammation{"Inflammation"}
    UCP2 -->|"activates"| Inflammation
    PINK1["PINK1"]
    UCP2 -->|"associated with"| PINK1
    Mitophagy(["Mitophagy"])
    UCP2 -->|"associated with"| Mitophagy
    INFLAMMATION["INFLAMMATION"]
    UCP2 -->|"activates"| INFLAMMATION
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    UCP2 -->|"activates"| MICROGLIA_ACTIVATION
    Immune_Response(["Immune Response"])
    UCP2 -->|"activates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    UCP2 -->|"implicated in"| neurodegeneration
    LC3B["LC3B"]
    LC3B -->|"protects against"| UCP2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"associated with"| UCP2
    NRG1["NRG1"]
    NRG1 -->|"regulates"| UCP2
    POMC["POMC"]
    POMC -->|"activates"| UCP2
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| UCP2
    AND["AND"]
    AND -->|"activates"| UCP2
    style UCP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0