concept

IL-22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

1Analyses

50Outgoing

27Incoming

0Experiments

1Debates

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💡 Concept Info

Name	IL-22
Key Genes/Proteins	AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta, AMYLOID-BETA
Related Diseases	alpha-synuclein pathology, Als, ALS, Alzheimer, Anxiety
Related Pathways	Amyloid

Pathway Diagram

graph TD
    IL_22["IL-22"]
    IL_22 -->|"involved_in"| Th17_Th22_Pathway["Th17/Th22 Pathway"]
    IL_22 -->|"activates"| Alzheimer["Alzheimer"]
    IL_22 -->|"activates"| Als["Als"]
    IL_22 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_22 -->|"activates"| Tumor["Tumor"]
    IL_22 -->|"activates"| ALS["ALS"]
    IL_22 -->|"activates"| Inflammation["Inflammation"]
    NRF2["NRF2"] -->|"activates"| IL_22
    IL_10["IL-10"] -->|"activates"| IL_22
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| IL_22
    TNF["TNF"] -->|"activates"| IL_22
    CYTOKINES["CYTOKINES"] -->|"activates"| IL_22
    ALZHEIMER["ALZHEIMER"] -->|"activates"| IL_22
    APP["APP"] -->|"activates"| IL_22
    IL_4["IL-4"] -->|"activates"| IL_22

Outgoing (51)

Target	Relation	Type	Str
Th17/Th22 Pathway	involved_in	pathway	0.80
gut barrier integrity	enhances	mechanism	0.70
brain endothelial cells	inhibits	cell_type	0.70
Systemic Inflammation	regulates	phenotype	0.70
gut barrier	decreases_risk	phenotype	0.70
CNS inflammation	causes	phenotype	0.70
alpha-synuclein pathology	protective_against	disease	0.70
gut barrier enhancement	activates	mechanism	0.70
Neuroinflammation	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Anxiety	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Bdnf	inhibits	protein	0.60
STROKE	therapeutic_target	gene	0.60
RORC	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
AHR	inhibits	gene	0.60
AMYLOID-BETA	activates	gene	0.60
IL-6	activates	gene	0.60
IL-10	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Amyloid	activates	pathway	0.60
Tau Phosphorylation	activates	pathway	0.60
Aβ	activates	protein	0.60
Interleukin	activates	protein	0.60
Cytokine	activates	protein	0.60
Amyloid-Beta	activates	protein	0.60
APP/PS1	activates	gene	0.60
Cytokine	inhibits	protein	0.60
App	activates	protein	0.60
Il-1	inhibits	protein	0.60
ALZHEIMER	activates	gene	0.60
IL-1	activates	gene	0.60
IL-4	activates	gene	0.60
IL-17	activates	gene	0.60
TAU	activates	gene	0.60
ANXIETY	activates	gene	0.60
IL-17	inhibits	gene	0.60
Oxidative Stress	activates	pathway	0.60
Neuron	activates	cell_type	0.60
IL-6	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
SYP	inhibits	gene	0.60

Incoming (27)

Source	Relation	Type	Str
NRF2	activates	gene	0.60
IL-10	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
TNF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
IL-4	activates	gene	0.60
IL-6	activates	gene	0.60
IL-17	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
GUT-BRAIN AXIS	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
TNF-Α	activates	gene	0.60
ANXIETY	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
TAU	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IL-6	inhibits	gene	0.60
IL-17	inhibits	gene	0.60
SYP	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning IL-22 in their description or question text

No additional research found