IRE1A

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRE1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    IRE1A["IRE1A"]
    IRE1A -->|"inhibits"| PPARGC1A["PPARGC1A"]
    IRE1A -->|"inhibits"| thermogenesis["thermogenesis"]
    IRE1A -->|"activates"| Inflammation["Inflammation"]
    IRE1A -->|"activates"| Als["Als"]
    IRE1A -->|"activates"| Hepatitis["Hepatitis"]
    IRE1A -->|"inhibits"| lipolysis["lipolysis"]
    IRE1A -->|"inhibits"| browning["browning"]
    IRE1A -->|"activates"| obesity["obesity"]
    IRE1A -->|"inhibits"| beige_adipocytes["beige_adipocytes"]
    IRE1A -->|"inhibits"| Cholesterol["Cholesterol"]
    XBP1["XBP1"] -->|"activates"| IRE1A
    GENES["GENES"] -->|"activates"| IRE1A
    ERN1["ERN1"] -->|"activates"| IRE1A
    PIK3C3["PIK3C3"] -->|"activates"| IRE1A
    MITOPHAGY["MITOPHAGY"] -->|"activates"| IRE1A
    YWHAG["YWHAG"] -->|"activates"| IRE1A
    RICTOR["RICTOR"] -->|"activates"| IRE1A
    AKT["AKT"] -->|"activates"| IRE1A
    ENDOG["ENDOG"] -->|"activates"| IRE1A
    MTORC1["MTORC1"] -->|"activates"| IRE1A