RICTOR

Understanding Entity Pages

This page aggregates everything SciDEX knows about RICTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RICTOR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 237 entities in the SciDEX knowledge graph.

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flowchart TD
    RICTOR["RICTOR<br/>mTORC2 Component"]
    MTOR["MTOR<br/>Mechanistic Target<br/>of Rapamycin"]
    mTORC2["mTORC2<br/>Complex"]
    AKT_pathway["AKT Signaling<br/>Pathway"]
    PI3K_pathway["PI3K/AKT<br/>Pathway"]
    
    PIK3C3["PIK3C3<br/>Autophagy Regulator"]
    Autophagy["Autophagy<br/>Cellular Clearance"]
    AMBRA1["AMBRA1<br/>Autophagy Regulator"]
    FIP200["FIP200<br/>Autophagy Initiator"]
    
    EGFR["EGFR<br/>Growth Factor<br/>Receptor"]
    PPARG["PPARG<br/>Metabolic<br/>Regulator"]
    HSPA5["HSPA5<br/>ER Stress<br/>Response"]
    
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    Dementia["Dementia"]
    
    RICTOR --|"forms complex"|--> mTORC2
    RICTOR --|"interacts with"|--> MTOR
    mTORC2 --|"activates"|--> AKT_pathway
    AKT_pathway --|"promotes"|--> PI3K_pathway
    
    RICTOR --|"interacts with"|--> PIK3C3
    PIK3C3 --|"regulates"|--> Autophagy
    RICTOR --|"interacts with"|--> AMBRA1
    RICTOR --|"interacts with"|--> FIP200
    AMBRA1 --|"promotes"|--> Autophagy
    FIP200 --|"initiates"|--> Autophagy
    
    RICTOR --|"interacts with"|--> EGFR
    RICTOR --|"interacts with"|--> PPARG
    RICTOR --|"interacts with"|--> HSPA5
    
    RICTOR --|"activates"|--> ALS
    RICTOR --|"activates"|--> MS
    RICTOR --|"activates"|--> Dementia
    Autophagy --|"dysfunction leads to"|--> ALS
    
    style RICTOR fill:#006494
    style mTORC2 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style Autophagy fill:#1b5e20
    style PIK3C3 fill:#4a1a6b
    style AMBRA1 fill:#4a1a6b
    style FIP200 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Dementia fill:#ef5350
    style AKT_pathway fill:#5d4400
    style PI3K_pathway fill:#5d4400