Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cholesterol: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cholesterol is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 838 entities in the SciDEX knowledge graph.
| Name | Cholesterol |
| Key Genes/Proteins | APOE, GENES, INFLAMMATION, CANCER, AUTOPHAGY |
| Related Diseases | Als, Cardiovascular, Atherosclerosis, Inflammation, Cancer |
| Linked Hypotheses | 11 hypotheses |
Knowledge base pages for this entity
graph TD
Cholesterol["Cholesterol"] -->|"interacts"| Mtor["Mtor"]
Cholesterol["Cholesterol"] -->|"interacts"| Apoptosis["Apoptosis"]
Cholesterol["Cholesterol"] -->|"interacts"| Lipid_Metabolism["Lipid Metabolism"]
Cholesterol["Cholesterol"] -->|"interacts"| Autophagy["Autophagy"]
Cholesterol["Cholesterol"] -->|"interacts"| Ferroptosis["Ferroptosis"]
Cholesterol["Cholesterol"] -->|"interacts"| Akt["Akt"]
ACTB["ACTB"] -->|"interacts"| Cholesterol["Cholesterol"]
P2RY12["P2RY12"] -.->|"inhibits"| Cholesterol["Cholesterol"]
APOA1["APOA1"] -->|"interacts"| Cholesterol["Cholesterol"]
ULK1["ULK1"] -->|"interacts"| Cholesterol["Cholesterol"]
style Cholesterol fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Astrocyte | regulates | cell_type | 0.80 |
| Mtor | interacts_with | pathway | 0.55 |
| Apoptosis | interacts_with | pathway | 0.55 |
| Lipid Metabolism | interacts_with | pathway | 0.55 |
| Autophagy | interacts_with | pathway | 0.55 |
| Ferroptosis | interacts_with | pathway | 0.55 |
| Akt | interacts_with | pathway | 0.55 |
| Endocytosis | interacts_with | pathway | 0.55 |
| Immune Response | interacts_with | pathway | 0.55 |
| Mitophagy | interacts_with | pathway | 0.55 |
| Glycolysis | interacts_with | pathway | 0.55 |
| Hedgehog | interacts_with | pathway | 0.55 |
| Unfolded Protein Response | interacts_with | pathway | 0.55 |
| Histone Modification | interacts_with | pathway | 0.55 |
| Nf-Κb | interacts_with | pathway | 0.55 |
| Oxidative Stress | interacts_with | pathway | 0.55 |
| Pi3K | interacts_with | pathway | 0.55 |
| RAPAMYCIN | activates | concept | 0.50 |
| atherosclerosis | activates | disease | 0.50 |
| AUTOPHAGOSOME | activates | concept | 0.50 |
| SOAT1 | inhibits | concept | 0.50 |
| SOAT1 | associated_with | concept | 0.50 |
| SOAT1 | activates | concept | 0.50 |
| CHOLESTEROL METABOLISM | activates | concept | 0.50 |
| Astrocytes | activates | cell_type | 0.50 |
| Tauopathy | activates | disease | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| Insulin Resistance | inhibits | disease | 0.50 |
| INSULIN | inhibits | concept | 0.50 |
| MTORC1 | inhibits | concept | 0.50 |
| LYSOSOME | inhibits | gene | 0.50 |
| NUCLEUS | activates | concept | 0.50 |
| Endocytosis | regulates | pathway | 0.50 |
| PCSK9 | associated_with | concept | 0.50 |
| atherosclerosis | protects_against | disease | 0.50 |
| SREBP2 | activates | concept | 0.50 |
| atherosclerosis | inhibits | disease | 0.50 |
| CHOLESTEROL METABOLISM | inhibits | concept | 0.50 |
| disease | associated_with | disease | 0.50 |
| CARDIOVASCULAR DISEASE | associated_with | concept | 0.50 |
| CHOLESTEROL METABOLISM | regulates | concept | 0.50 |
| atherosclerosis | regulates | disease | 0.50 |
| atherosclerosis | expressed_in | disease | 0.50 |
| Macrophage | expressed_in | cell_type | 0.50 |
| MACROPHAGES | expressed_in | concept | 0.50 |
| Lymphoma | activates | disease | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| B Cell | activates | cell_type | 0.50 |
| MACROPHAGES | activates | concept | 0.50 |
| CHRONIC INFLAMMATION | causes | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | inhibits | gene | 1.00 |
| APOE | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Cardiovascular | regulates | disease | 1.00 |
| Atherosclerosis | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| MIRNAS | regulates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| APOE | associated_with | gene | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| Atherosclerosis | inhibits | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| MICRORNAS | regulates | gene | 1.00 |
| Atherosclerosis | associated_with | disease | 0.95 |
| EGFR | activates | gene | 0.90 |
| AKT | inhibits | gene | 0.90 |
| Atherosclerosis | activates | disease | 0.90 |
| APOE4 | activates | gene | 0.90 |
| Inflammation | inhibits | disease | 0.90 |
| GENES | activates | gene | 0.90 |
| Cardiovascular | associated_with | disease | 0.90 |
| Als | biomarker_for | disease | 0.90 |
| Alzheimer | regulates | disease | 0.90 |
| Tumor | inhibits | disease | 0.90 |
| Als | therapeutic_target | disease | 0.90 |
| PI3K | activates | gene | 0.90 |
| INFLAMMATION | therapeutic_target | gene | 0.90 |
| INFLAMMATION | inhibits | gene | 0.90 |
| INFLAMMATION | regulates | gene | 0.90 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.90 |
| SREBP2 | activates | gene | 0.90 |
| OXIDATIVE STRESS | activates | gene | 0.90 |
| AUTOPHAGY | regulates | gene | 0.90 |
| STROKE | activates | gene | 0.90 |
| Stroke | activates | disease | 0.90 |
| ALZHEIMER | therapeutic_target | gene | 0.90 |
| Obesity | regulates | disease | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Mediated Cholesterol Dysregulation in Microglial Senes | 0.574 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulati | 0.563 | neuroimmunology | What is the temporal sequence of TREM2 s |
| Membrane Cholesterol Gradient Modulators | 0.517 | neurodegeneration | Lipid raft composition changes in synapt |
| Cholesterol-CRISPR Convergence Therapy for Neurodegeneration | 0.484 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505
neuroscience | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892] | Wang Y, An H, Liu T, Qin C, Sesaki H, Gu | Cell Rep | 2019 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associatio [PMID:41037108] | Díaz-Belloso R, Martín-Bornez M, Macías- | Journal of neurology | 2025 | 0 |
| Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789] | ["Zhu J", "Wei R", "Hu G", "Wang H", "Wa | Small (Weinheim an der Bergstr | 2024 | 0 |
| RNA-Independent Regulatory Functions of lncRNA in Complex Disease. [PMID:39123456] | ["Kafida M", "Karela M", "Giakountis A"] | Cancers | 2024 | 0 |
| 25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain [PMID:39181516] | Loiola RA, Nguyen C, Dib S, Saint-Pol J, | Biochimica et biophysica acta. | 2024 | 0 |
| Raccoon eyes. [PMID:35789012] | Ning J | Journal of paediatrics and chi | 2023 | 0 |
| Isolated Trapeziometacarpal Joint Dislocation With Five Years of Follow-up: A Ca [PMID:36891023] | ["Missaoui Z", "Moussa M", "Boushnak M", | Cureus | 2023 | 0 |
| Exploring factors associated with preferences for human papillomavirus (HPV) sel [PMID:37234567] | ["Xiong S", "Ghebre R", "Kulasingam S", | Preventive medicine reports | 2023 | 0 |
| Patient's Knowledge and Perception of Endodontics Treatment: An Observational St [PMID:37654321] | ["Manasa N", "Naik K", "Singh M", "Moiz | Journal of pharmacy & bioallie | 2023 | 0 |
| Photosynthetic acclimation to changing environments. [PMID:36892145] | ["Gjindali A", "Johnson G"] | Biochemical Society transactio | 2023 | 0 |
| Cholinergic neurodegeneration and cholesterol metabolism dysregulation by consti [PMID:37900943] | ["Comaposada-Bar\u00f3 R", "Benito-Mart\ | Frontiers in molecular neurosc | 2023 | 0 |
| Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its deri [PMID:34567823] | ["Manjunath S", "Thimmulappa R"] | Journal of pharmaceutical anal | 2022 | 0 |
| ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheim [PMID:35236834] | Zhao Y, Hu D, Wang R, Sun X, Ropelewski | Nature communications | 2022 | 0 |
| Comparative study of haemodynamic effects of intravenous ketamine-fentanyl and p [PMID:35102948] | ["Okeyemi A", "Suleiman A", "Oyedepo O", | The Nigerian postgraduate medi | 2022 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Ambulatory Care Sensitive Conditions in Pediatrics: Time for a Reassessment. [PMID:34215678] | Lu S | Pediatrics | 2021 | 0 |