gene

SMCR8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMCR8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

240Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SMCR8 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with AD, ALI, AMI. Connected to 107 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SMCR8
Full Name	SMCR8, SMOX Modifier 1
Aliases	C9orf72 modifier, FTDALS2
Chromosome	9p21.1
Function	SMCR8 (SMCR8 - SMOX Modifier 1) is a protein coding gene that functions as a positive regulator of autophagy and lysosomal trafficking.
Primary Expression	neurons and glial cells, where it participates in cellular clearance mechanisms critical for neuronal health
Molecular Weight	~53 kDa
Amino Acids	479 aa
Exons	12
Pathways	Autophagy, Mtor, Oxidative Stress
UniProt ID	Q8TBX5
NCBI Gene ID	94015
GeneCards	SMCR8
Human Protein Atlas	SMCR8
Gene Length	35.2 kb
Associated Diseases	AD, ALI, AMI, Als, Ftd, ILD
Known Drugs/Compounds	rapamycin
Interactions	CALCOCO2, LC3, BECN1, C9ORF72, NBR1, G3BP1
KG Connections	240 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMCR8 — AlphaFold Q8TBX5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SMCR8["SMCR8"]
    SMCR8 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMCR8 -->|"interacts"| Dementia["Dementia"]
    SMCR8 -->|"interacts"| Als["Als"]
    SMCR8 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    SMCR8 -->|"interacts"| Ftd["Ftd"]
    SMCR8 -->|"interacts"| Ms["Ms"]
    SMCR8 -->|"interacts"| Inflammation["Inflammation"]
    SMCR8 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    WDR41["WDR41"] -->|"interacts"| SMCR8
    ACTB["ACTB"] -->|"interacts"| SMCR8
    OPTN["OPTN"] -->|"interacts"| SMCR8
    ULK1["ULK1"] -->|"interacts"| SMCR8
    SQSTM1["SQSTM1"] -->|"interacts"| SMCR8
    MAP1LC3["MAP1LC3"] -->|"interacts"| SMCR8
    WIPI2["WIPI2"] -->|"regulates"| SMCR8
    C9ORF72["C9ORF72"] -->|"interacts"| SMCR8
    MTOR["MTOR"] -->|"regulates"| SMCR8
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"regulates"| SMCR8

Outgoing (143)

Target	Relation	Type	Str
ULK1	regulates	entity	0.88
BECN1	regulates	entity	0.70
autophagy pathway	participates_in	pathway	0.70
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Ftd	inhibits	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
CALCOCO2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
ULK1	expressed_in	gene	0.60
WIPI2	regulates	gene	0.60
P62	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
WDR41	interacts_with	gene	0.60
ULK1	associated_with	gene	0.60
TFEB	regulates	gene	0.60
FLCN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
SQSTM1	activates	entity	0.60
TAX1BP1	activates	entity	0.60
TOLLIP	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
ULK1	activates	entity	0.60
C9ORF72	inhibits	gene	0.60

Incoming (97)

Source	Relation	Type	Str
WDR41	interacts_with	protein	0.70
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
WIPI2	regulates	gene	0.60
C9ORF72	interacts_with	gene	0.60
FIP200	associated_with	gene	0.60
MTOR	regulates	gene	0.60
FIP200	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
ULK1	expressed_in	gene	0.60
ULK1	associated_with	gene	0.60
TFEB	regulates	gene	0.60
ACTB	activates	entity	0.60
BECN1	activates	entity	0.60
C9ORF72	activates	entity	0.60
CALCOCO2	activates	entity	0.60
FUS	activates	entity	0.60
G3BP1	activates	entity	0.60
NBR1	activates	entity	0.60
NDP52	activates	entity	0.60
OPTINEURIN	activates	entity	0.60
OPTN	activates	entity	0.60
P62	activates	entity	0.60
RAB8A	inhibits	gene	0.60
C9ORF72	inhibits	gene	0.60
LC3	activates	gene	0.60
EIF2A	activates	gene	0.60
FIP200	activates	gene	0.60
RAN	activates	gene	0.60
RB1	activates	gene	0.60
RB1CC1	activates	gene	0.60
MAP1LC3	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
TRIM21	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.537	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SMCR8

Understanding Entity Pages

Summary

Wiki Pages (17)

SMCR8 Gene

RAB9A

Oxidative Stress in Neurodegeneration

autophagy-lysosome-dysfunction

C9orf72 Protein

c9orf72-protein

ALS-FTD Overlap: Mechanistic Pathways

WDR41 Gene

Motor Neurons in C9orf72-Linked ALS/FTD

Macroautophagy

C9orf72 — Chromosome 9 Open Reading Frame 72

c9orf72-als-ftd-phenotype-mechanism

Amyotrophic Lateral Sclerosis

C9orf72 iPSC-Derived Neurons

C9orf72 Protein (Chromosome 9 Open Reading Frame 72)