disease

Sepsis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Sepsis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

797Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

No summary available yet. View on Wiki →

Disease Info
Associated GenesAQP4, MMP9, S100A8, HIF, TREM2, CYTOKINES, AKT, MTOR
Therapeutic AgentsPCTR1
KG Connections718 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (20)

Knowledge base pages for this entity

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mechanism · 4656 words

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therapeutic · 4392 words

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

gene · 3284 words

Biomarkers of Alzheimer Disease

mechanism · 3115 words

Basilea Pharmaceutica AG

company · 3108 words

Pathway Diagram

graph TD
    Sepsis["<b>Sepsis</b>"]
    Immune_Response["Immune Response"]
    Sepsis -->|"activates"| Immune_Response
    Acute_Kidney_Injury{"Acute Kidney Injury"}
    Sepsis -->|"causes"| Acute_Kidney_Injury
    Mortality["Mortality"]
    Sepsis -->|"causes"| Mortality
    Mtor["Mtor"]
    Sepsis -->|"activates"| Mtor
    Nf__b["Nf-Kappab"]
    Sepsis -.->|"inhibits"| Nf__b
    Ferroptosis["Ferroptosis"]
    Sepsis -->|"activates"| Ferroptosis
    AKT(["AKT"])
    AKT -->|"activates"| Sepsis
    Als{"Als"}
    Als -->|"activates"| Sepsis
    CYTOKINES(["CYTOKINES"])
    CYTOKINES -->|"activates"| Sepsis
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"regulates"| Sepsis
    style Sepsis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (182)

TargetRelationTypeStr
Immune Responseactivatespathway1.00
Blood-Brain Barrier Disruptioncausesprocess0.95
Immunosuppressioncausesprocess0.95
Organ Dysfunctioncausesphenotype0.95
Sepsis-Induced Immunosuppressioncausesprocess0.95

Incoming (615)

SourceRelationTypeStr
AKTactivatesgene1.00
Alsactivatesdisease1.00
CYTOKINESactivatesgene1.00
INFLAMMATIONregulatesgene1.00
Alstherapeutic_targetdisease1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found