disease

Sepsis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Sepsis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

777Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	AIM2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, ANGPT1, APOPTOSIS, AQP1, AQP4
Therapeutic Agents	PCTR1
KG Connections	693 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    Sepsis["Sepsis"]
    Immune_Response["Immune Response"]
    Sepsis -->|"activates"| Immune_Response
    Acute_Kidney_Injury{"Acute Kidney Injury"}
    Sepsis -->|"causes"| Acute_Kidney_Injury
    Mortality["Mortality"]
    Sepsis -->|"causes"| Mortality
    Mtor["Mtor"]
    Sepsis -->|"activates"| Mtor
    Nf__b["Nf-Kappab"]
    Sepsis -.->|"inhibits"| Nf__b
    Ferroptosis["Ferroptosis"]
    Sepsis -->|"activates"| Ferroptosis
    AKT(["AKT"])
    AKT -->|"activates"| Sepsis
    Als{"Als"}
    Als -->|"activates"| Sepsis
    CYTOKINES(["CYTOKINES"])
    CYTOKINES -->|"activates"| Sepsis
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"regulates"| Sepsis
    style Sepsis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (176)

Target	Relation	Type	Str
Immune Response	activates	pathway	1.00
Immunosuppression	causes	process	0.95
Sepsis-Associated Encephalopathy	causes	disease	0.95
Blood-Brain Barrier Disruption	causes	process	0.95
Organ Dysfunction	causes	phenotype	0.95
Sepsis-Induced Immunosuppression	causes	process	0.95
Acute Kidney Injury	causes	disease	0.92
Septic Cardiomyopathy	causes	disease	0.90
gut barrier injury	causes	phenotype	0.90
Acute Lung Injury	causes	disease	0.90
Mortality	causes	phenotype	0.90
Mtor	activates	pathway	0.90
Nf-Κb	inhibits	pathway	0.90
Liver Injury	causes	phenotype	0.85
Brain Inflammation	causes	process	0.85
Inflammation	therapeutic_target	disease	0.85
Ferroptosis	activates	pathway	0.85
Apoptosis	activates	pathway	0.85
Autophagy	associated_with	pathway	0.85
Early Diagnosis	associated_with	process	0.80
Antibiotic Overuse	contributes_to	phenotype	0.80
Nf-Κb	activates	pathway	0.80
Pyroptosis	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Immune Response	causes	pathway	0.80
Oxidative Stress	inhibits	pathway	0.80
Mitophagy	activates	pathway	0.75
Inflammation	activates	disease	0.75
ALI	causes	disease	0.72
Glycolysis	regulates	pathway	0.70
Mtor	regulates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Epigenetic	activates	pathway	0.70
Glycolysis	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Inflammasome	treats	pathway	0.70
Pi3K/Akt	activates	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Ferroptosis	associated_with	pathway	0.70
Mitophagy	inhibits	pathway	0.70
Mapk	regulates	pathway	0.70
Lipid Metabolism	therapeutic_target	pathway	0.70
Toll-Like Receptor	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Apoptosis	inhibits	pathway	0.70
Apoptosis	treats	pathway	0.70
Innate Immunity	regulates	pathway	0.70
Adaptive Immunity	regulates	pathway	0.70
sepsis-associated encephalopathy	causes	disease	0.70
Autoimmune	regulates	disease	0.65

Incoming (601)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	1.00
Als	activates	disease	1.00
AKT	activates	gene	1.00
Infection	causes	disease	1.00
INFLAMMATION	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
CYTOKINES	activates	gene	1.00
Cardiac	activates	disease	1.00
INFLAMMATION	regulates	gene	1.00
Als	therapeutic_target	disease	1.00
Inflammation	associated_with	disease	0.95
Inflammation	activates	disease	0.95
Infection	activates	disease	0.95
MTOR	activates	gene	0.95
NF-ΚB	inhibits	gene	0.95
Als	treats	disease	0.95
MITOCHONDRIA	activates	gene	0.95
Dysregulated Host Response	causes	mechanism	0.95
Glycocalyx	biomarker_for	biomarker	0.92
PKN2	biomarker_for	protein	0.90
Early Inflammatory Onset	involved_in	process	0.90
Hoxa Distal Transcript Antisense Rna	biomarker_for	biomarker	0.90
PROC	biomarker_for	protein	0.90
Dysregulated Host Response To Infection	causes	process	0.90
glycocalyx degradation	contributes_to	process	0.90
Dysregulated Thromboinflammation	causes	process	0.90
40634788	increases risk of	paper	0.90
NLRP6	protects_against	protein	0.90
27885969	impairs	paper	0.90
TREM2	risk_factor_for	gene	0.90
Immunosuppression	involved_in	process	0.90
Circular Rnas	biomarker_for	biomarker	0.90
Triiodothyronine	biomarker_for	compound	0.90
PCTR1	protects_against	compound	0.90
34764472	associated with	paper	0.90
34764472	causes	paper	0.90
Glycocalyx	therapeutic_target	biomarker	0.88
Pericyte-Derived Extracellular Vesicles	treats	cell_type	0.85
Strem-1	biomarker_for	biomarker	0.85
FERROPTOSIS	activates	gene	0.85
GPX4	activates	gene	0.85
Immunological Dysfunctions	associated_with	phenotype	0.85
Dysregulated Host Response	contributes_to	mechanism	0.85
Adrenomedullin	biomarker_for	biomarker	0.85
PCT	biomarker_for	biomarker	0.85
PCTR1	treats	compound	0.85
ERK	inhibits	gene	0.85
CRP	biomarker_for	biomarker	0.85
Procalcitonin	biomarker_for	biomarker	0.85
TREM2	therapeutic_target	gene	0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sepsis-Associated Encephalopathy Prevention via Early BBB St	0.000	-	Blood-brain barrier tight junction disru

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Sepsis in their description or question text

No additional research found