gene

SLC2A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC2A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

32Outgoing

25Incoming

Summary

SLC2A2 is a gene implicated in neurodegeneration research. Key relationships include: protects against, inhibits, implicated in. Associated with Als, Inflammation, Neurodegeneration. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC2A2
Full Name	SLC2A2
Aliases	GLUT2
Protein Type	Gene
Function	Unlike high-affinity glucose transporters such as GLUT1 (SLC2A1) or GLUT3 (SLC2A3), GLUT2 has a relatively low affinity for glucose (Km ~15-20 mM), which makes it well-suited for tissues where glucose
Primary Expression	tissues critical for metabolic homeostasis, including the liver, pancreas, intestine, kidney, and specific brain regions
NCBI Gene ID	Search NCBI
GeneCards	SLC2A2
Human Protein Atlas	SLC2A2
Associated Diseases	neurodegeneration
Interactions	SLC2A1, COX4I1, GSK3B, NRXN3, PRKAA1, BDNF
KG Connections	57 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC2A2["SLC2A2 (GLUT2)"]
    
    %% Upstream regulators
    BDNF["BDNF"]
    PRKAA1["PRKAA1 (AMPK-alpha1)"]
    NRXN3["NRXN3"]
    SOD1["SOD1"]
    SOD2["SOD2"]
    CREB["CREB"]
    
    %% Downstream targets
    SLC2A1["SLC2A1 (GLUT1)"]
    GSK3B["GSK3B"]
    COX4I1["COX4I1"]
    OxStress["Oxidative Stress"]
    
    %% Diseases/conditions
    Neuroinflam["Neuroinflammation"]
    ALS["ALS"]
    Neurodegeneration["Neurodegeneration"]
    Inflammation["Inflammation"]
    
    %% Connections
    BDNF -->|"inhibits"| SLC2A2
    PRKAA1 -->|"inhibits"| SLC2A2
    NRXN3 -->|"inhibits"| SLC2A2
    SOD1 -->|"inhibits"| SLC2A2
    SOD2 -->|"protects"| SLC2A2
    CREB -->|"protects"| SLC2A2
    
    SLC2A2 -->|"inhibits"| SLC2A1
    SLC2A2 -->|"inhibits"| GSK3B
    SLC2A2 -->|"inhibits"| COX4I1
    SLC2A2 -->|"inhibits"| OxStress
    
    SLC2A2 -->|"protects against"| Neuroinflam
    SLC2A2 -->|"protects against"| ALS
    SLC2A2 -->|"protects against"| Neurodegeneration
    SLC2A2 -->|"protects against"| Inflammation
    
    %% Styling
    style SLC2A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style SOD2 fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style CREB fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style BDNF fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style PRKAA1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style GSK3B fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style OxStress fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style ALS fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Neurodegeneration fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Neuroinflam fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Inflammation fill:#7d4200,stroke:#ff9800,stroke-width:2px

Outgoing (32)

Target	Relation	Type	Str
Neuroinflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
SLC2A1	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
AKT	protects_against	gene	0.60
SOD2	protects_against	gene	0.60
NRXN3	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
CYCS	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
CAT	inhibits	gene	0.60
Rb	inhibits	protein	0.60
PER	protects_against	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
AND	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Sod1	inhibits	pathway	0.60
PKM	inhibits	gene	0.60
Bdnf	inhibits	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress	inhibits	phenotype	0.50

Incoming (25)

Source	Relation	Type	Str
NRXN3	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
PSD95	protects_against	gene	0.60
CYCS	inhibits	gene	0.60
CAT	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
ABCC8	regulates	gene	0.60
ABCC8	interacts_with	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GENES	inhibits	gene	0.60
CREB	protects_against	gene	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PKM	inhibits	gene	0.60
PER	protects_against	gene	0.60
GSK3B	inhibits	gene	0.50
SLC2A1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC2A2

Understanding Entity Pages

Summary

Wiki Pages (8)

SLC2A2 Gene

Lateral Hypothalamus

SLC2A1 Gene

PDHA1

Section 218: Advanced Nutritional Genomics and Personalized Diet in CBS/PSP

SLC2A5 Gene