gene

PDHA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDHA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

38Outgoing

26Incoming

Summary

PDHA1 is a gene implicated in neurodegeneration research. Key relationships include: protects against, inhibits, implicated in. Associated with Als, Inflammation, Neurodegeneration. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PDHA1
Full Name	Pyruvate Dehydrogenase E1 Alpha 1
Chromosome	19q13.42
Protein Family	Pyruvate dehydrogenase complex (PDC) family
Function	is a heterotetramer composed of two α subunits (PDHA1 or PDHA2) and two β subunits (PDHB), forming the catalytic core of the larger pyruvate dehydrogenase complex[@hi2006].
Primary Expression	Ubiquitous (brain, heart, muscle, liver)
Subcellular Localization	Mitochondrial matrix
Molecular Weight	43 kDa
Amino Acids	390 aa
Exons	11
Pathways	NF-κB
UniProt ID	P21987
NCBI Gene ID	5165
Ensembl ID	ENSG00000131828
GeneCards	PDHA1
Human Protein Atlas	PDHA1
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Leigh Syndrome
Interactions	BDNF, PRKAA1, SOD1, NLGN2, CYCS, CAT
KG Connections	64 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDHA1 — AlphaFold P21987 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDHA1["PDHA1 (Pyruvate Dehydrogenase E1alpha)"]
    
    %% Metabolic pathway
    PDHA1 -->|"converts"| Pyruvate["Pyruvate -> Acetyl-CoA"]
    Pyruvate -->|"fuels"| Mitochondria["Mitochondrial Function"]
    
    %% Protective mechanisms
    PDHA1 -->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PDHA1 -->|"protects against"| Neuroinflammation["Neuroinflammation"]
    PDHA1 -->|"protects against"| ALS["ALS"]
    
    %% Energy metabolism regulation
    PDHA1 -->|"inhibits"| PRKAA1["PRKAA1 (AMPK)"]
    PRKAA1 -->|"signals"| EnergyStress["Energy Stress Response"]
    
    %% Oxidative stress pathway
    PDHA1 -->|"inhibits"| OxidativeStress["Oxidative Stress"]
    OxidativeStress -->|"damages"| Neurons["Neuronal Damage"]
    PDHA1 -->|"inhibits"| SOD1["SOD1"]
    SOD1 -->|"when mutated"| ALS
    
    %% Apoptosis regulation
    PDHA1 -->|"inhibits"| CYCS["CYCS (Cytochrome C)"]
    CYCS -->|"triggers"| Apoptosis["Apoptosis"]
    
    %% Glucose metabolism
    PDHA1 -->|"inhibits"| SLC2A1["SLC2A1 (GLUT1)"]
    PDHA1 -->|"inhibits"| SLC2A2["SLC2A2 (GLUT2)"]
    SLC2A1 -->|"transports"| GlucoseUptake["Glucose Uptake"]
    
    %% Synaptic function
    PDHA1 -->|"inhibits"| NLGN2["NLGN2 (Neuroligin-2)"]
    NLGN2 -->|"regulates"| SynapticFunction["Synaptic Function"]
    
    %% Styling
    style PDHA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,color:#e0e0e0
    style ALS fill:#7d4200,color:#e0e0e0
    style Mitochondria fill:#1b5e20,color:#e0e0e0
    style PRKAA1 fill:#4a1a6b,color:#e0e0e0
    style SOD1 fill:#4a1a6b,color:#e0e0e0
    style CYCS fill:#4a1a6b,color:#e0e0e0
    style SLC2A1 fill:#4a1a6b,color:#e0e0e0
    style NLGN2 fill:#4a1a6b,color:#e0e0e0
    style OxidativeStress fill:#ef5350,color:#e0e0e0
    style EnergyStress fill:#ef5350,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Neuroinflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
PSD95	protects_against	gene	0.60
CYCS	inhibits	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
COX4I1	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
AKT	protects_against	gene	0.60
NRXN3	inhibits	gene	0.60
Rb	inhibits	protein	0.60
NEURODEGENERATION	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GENES	inhibits	gene	0.60
CREB	protects_against	gene	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PER	protects_against	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Sod1	inhibits	pathway	0.60
PKM	inhibits	gene	0.60
Bdnf	inhibits	protein	0.60
SLC2A1	activates	gene	0.55
PKM2	activates	gene	0.55
unfolded protein response	participates_in	pathway	0.55
astrocytes	expressed_in	cell_type	0.55
oxidative stress	inhibits	phenotype	0.50

Incoming (26)

Source	Relation	Type	Str
NRXN3	inhibits	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
COX4I1	inhibits	gene	0.60
SLC2A1	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
GSK3B	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
CYCS	inhibits	gene	0.60
AKT	protects_against	gene	0.60
PKM	inhibits	gene	0.60
GLUT4	protects_against	gene	0.60
PER	protects_against	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
INFLAMMATION	protects_against	gene	0.60
AND	inhibits	gene	0.60
HK2	activates	gene	0.55
GLUT1	activates	gene	0.55
LDHA	activates	gene	0.55
Sod1	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PDHA1

Understanding Entity Pages

Summary

Wiki Pages (17)

PDHA1

PDHX Gene

pdp1

Mitochondrially Impaired Neurons

DLST — Dihydrolipoamide Succinyltransferase

SLC2A1 Gene

PPAR Signaling Pathway in Neurodegeneration

DLAT Gene

Leigh Syndrome

Intellectual Disability

E2 - Dihydrolipoamide S-Acetyltransferase

PDP1 Protein

PDHA2 Protein

NRXN3 Gene

PDHA1 Protein — Pyruvate Dehydrogenase E1 Alpha 1

Proteins

Genes

Pathway Diagram

Outgoing (38)

Incoming (26)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)