Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about sca3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SCA3 |
| Full Name | Ataxin-3 |
| Chromosome | 14q32.1. |
| Function | is a 361-amino acid protein encoded by the ATXN3 gene located on chromosome 14q32. |
| Amino Acids | 361 aa |
| UniProt ID | [Q9UHD8](https://www.uniprot.org/uniprotkb/Q9UHD8/entry) |
| GeneCards | SCA3 |
| Human Protein Atlas | SCA3 |
| Associated Diseases | Ataxia, Spinocerebellar Ataxia, disease |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SCA3["SCA3"]
SCA3 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
SCA3 -->|"regulates"| Ms["Ms"]
SCA3 -->|"regulates"| DNAJB1["DNAJB1"]
SCA3 -->|"regulates"| Lysosomal_Degradation["Lysosomal Degradation"]
SCA3 -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
SCA3 -->|"regulates"| Autophagy["Autophagy"]
SCA3 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
SCA3 -->|"implicated in"| RAB7["RAB7"]
SCA3 -->|"implicated in"| ATG12["ATG12"]
HSPA1A["HSPA1A"] -->|"regulates"| SCA3
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| SCA3
NEURODEGENERATION["NEURODEGENERATION"] -->|"implicated in"| SCA3
ATG5["ATG5"] -->|"implicated in"| SCA3
RAB5["RAB5"] -->|"implicated in"| SCA3
ATG1["ATG1"] -->|"implicated in"| SCA3| Target | Relation | Type | Str |
|---|---|---|---|
| ATXN3 | causes | gene | 0.50 |
| Ataxia | causes | disease | 0.50 |
| Spinocerebellar Ataxia | causes | disease | 0.50 |
| GAIN | regulates | gene | 0.50 |
| disease | regulates | disease | 0.50 |
| ATXN3 | expressed_in | gene | 0.50 |
| BRAINSTEM | expressed_in | concept | 0.50 |
| ATXN3 | associated_with | gene | 0.50 |
| Oligodendrocyte | associated_with | cell_type | 0.50 |
| White Matter | associated_with | process | 0.50 |
| OLIGODENDROCYTES | associated_with | concept | 0.50 |
| TNFRSF13C | associated_with | gene | 0.50 |
| disease | associated_with | disease | 0.50 |
| BRAINSTEM | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | regulates | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||