gene

TNFSF10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFSF10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections
0Hypotheses
0Analyses
34Outgoing
11Incoming

Summary

TNFSF10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTNFSF10
Full NameTNF Superfamily Member 10 (TNF-Related Apoptosis-Inducing Ligand)
Chromosome3q26.1
Protein FamilyTNF superfamily, Type II transmembrane proteins
Functionis a member of the tumor necrosis factor (TNF) superfamily that plays complex roles in cell death, immune surveillance, and neuroinflammation.
Amino Acids281 aa
PathwaysApoptosis, Immune Response
UniProt ID[P50591](https://www.uniprot.org/uniprot/P50591)
Ensembl IDENSG00000117586
GeneCardsTNFSF10
Human Protein AtlasTNFSF10
TRAIL-αFull-length membrane-bound form
TRAIL-βSoluble form generated by proteolytic cleavage
TRAIL-γTruncated variant with altered signaling
Associated DiseasesAls, Cancer, Carcinoma, Ms, Tumor
InteractionsTNFRSF1A, FYCO1, DR5, TRAIL, CASP8, TNF
KG Connections45 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

TRAIL Gene (TNFSF10)

gene · 2784 words

FOXO1 Protein

protein · 3787 words

TRAIL (TNF-Related Apoptosis-Inducing Ligand) Protein

protein · 1206 words

TRAIL (TNFSF10) Protein

protein · 669 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    TNFSF10["<b>TNFSF10</b>"]
    Als{"Als"}
    TNFSF10 -->|"associated with"| Als
    Tumor{"Tumor"}
    TNFSF10 -->|"associated with"| Tumor
    Cancer{"Cancer"}
    TNFSF10 -->|"associated with"| Cancer
    Ms{"Ms"}
    TNFSF10 -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    TNFSF10 -->|"associated with"| Carcinoma
    MAP1LC3B["MAP1LC3B"]
    TNFSF10 -->|"associated with"| MAP1LC3B
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    TNFSF10 -->|"associated with"| AUTOPHAGY_RELATED_GENES
    Apoptosis(["Apoptosis"])
    TNFSF10 -->|"associated with"| Apoptosis
    Autophagy(["Autophagy"])
    TNFSF10 -->|"associated with"| Autophagy
    Lipid_Metabolism(["Lipid Metabolism"])
    TNFSF10 -->|"associated with"| Lipid_Metabolism
    Er_Stress(["Er Stress"])
    TNFSF10 -->|"associated with"| Er_Stress
    neurodegeneration["neurodegeneration"]
    TNFSF10 -->|"implicated in"| neurodegeneration
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| TNFSF10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| TNFSF10
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| TNFSF10
    P4HB["P4HB"]
    P4HB -->|"associated with"| TNFSF10
    SOD2["SOD2"]
    SOD2 -->|"associated with"| TNFSF10
    CD8["CD8"]
    CD8 -->|"associated with"| TNFSF10
    CANCER["CANCER"]
    CANCER -->|"associated with"| TNFSF10
    APOE["APOE"]
    APOE -->|"associated with"| TNFSF10
    style TNFSF10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

TargetRelationTypeStr
ILC1expressed_incell_type0.80
Alsassociated_withdisease0.65
Tumorassociated_withdisease0.65
Cancerassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (11)

SourceRelationTypeStr
P4HBassociated_withgene0.60
SOD2associated_withgene0.60
CD8associated_withgene0.60
APOEassociated_withgene0.60
RAB7Aactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found