Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNFSF10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNFSF10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Cancer, Carcinoma. Connected to 20 entities in the SciDEX knowledge graph.
| Gene Symbol | TNFSF10 |
| Full Name | TNF Superfamily Member 10 (TNF-Related Apoptosis-Inducing Ligand) |
| Chromosome | 3q26.1 |
| Protein Family | TNF superfamily, Type II transmembrane proteins |
| Function | is a member of the tumor necrosis factor (TNF) superfamily that plays complex roles in cell death, immune surveillance, and neuroinflammation. |
| Amino Acids | 281 aa |
| Pathways | Apoptosis, Immune Response |
| UniProt ID | [P50591](https://www.uniprot.org/uniprot/P50591) |
| Ensembl ID | ENSG00000117586 |
| GeneCards | TNFSF10 |
| Human Protein Atlas | TNFSF10 |
| TRAIL-α | Full-length membrane-bound form |
| TRAIL-β | Soluble form generated by proteolytic cleavage |
| TRAIL-γ | Truncated variant with altered signaling |
| Associated Diseases | Als, Cancer, Carcinoma, Ms, Tumor |
| Interactions | TNFRSF1A, FYCO1, DR5, TRAIL, CASP8, TNF |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TNFSF10["<b>TNFSF10</b>"]
Als{"Als"}
TNFSF10 -->|"associated with"| Als
Tumor{"Tumor"}
TNFSF10 -->|"associated with"| Tumor
Cancer{"Cancer"}
TNFSF10 -->|"associated with"| Cancer
Ms{"Ms"}
TNFSF10 -->|"associated with"| Ms
Carcinoma{"Carcinoma"}
TNFSF10 -->|"associated with"| Carcinoma
MAP1LC3B["MAP1LC3B"]
TNFSF10 -->|"associated with"| MAP1LC3B
AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
TNFSF10 -->|"associated with"| AUTOPHAGY_RELATED_GENES
Apoptosis(["Apoptosis"])
TNFSF10 -->|"associated with"| Apoptosis
Autophagy(["Autophagy"])
TNFSF10 -->|"associated with"| Autophagy
Lipid_Metabolism(["Lipid Metabolism"])
TNFSF10 -->|"associated with"| Lipid_Metabolism
Er_Stress(["Er Stress"])
TNFSF10 -->|"associated with"| Er_Stress
neurodegeneration["neurodegeneration"]
TNFSF10 -->|"implicated in"| neurodegeneration
IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
IMMUNE_INFILTRATION -->|"associated with"| TNFSF10
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"associated with"| TNFSF10
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"associated with"| TNFSF10
P4HB["P4HB"]
P4HB -->|"associated with"| TNFSF10
SOD2["SOD2"]
SOD2 -->|"associated with"| TNFSF10
CD8["CD8"]
CD8 -->|"associated with"| TNFSF10
CANCER["CANCER"]
CANCER -->|"associated with"| TNFSF10
APOE["APOE"]
APOE -->|"associated with"| TNFSF10
style TNFSF10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ILC1 | expressed_in | cell_type | 0.80 |
| Als | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Necroptosis | activates | disease | 0.65 |
| MAP1LC3B | associated_with | gene | 0.60 |
| TNFRSF1A | activates | gene | 0.60 |
| FYCO1 | activates | gene | 0.60 |
| DR5 | activates | gene | 0.60 |
| TRAIL | activates | gene | 0.60 |
| CASP8 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| PAH | activates | gene | 0.60 |
| CANX | activates | gene | 0.60 |
| PYCARD | activates | gene | 0.60 |
| APAF1 | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| AUTOPHAGY-RELATED GENES | associated_with | gene | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Er Stress | associated_with | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| IL-1B | activates | gene | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Raf | activates | protein | 0.60 |
| Il-1 | activates | protein | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P4HB | associated_with | gene | 0.60 |
| SOD2 | associated_with | gene | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| CALR | activates | gene | 0.60 |
| RIPK1 | activates | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||