TRAIL

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAIL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Comprehensive information about TRAIL (TNF-Related Apoptosis-Inducing Ligand), a member of the TNF superfamily involved in neuronal apoptosis, neuroinflammation, and neurodegenerative diseases

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graph TD
    TRAIL["<b>TRAIL</b>"]
    ALS{"ALS"}
    TRAIL -->|"activates"| ALS
    Inflammation{"Inflammation"}
    TRAIL -->|"activates"| Inflammation
    Cancer{"Cancer"}
    TRAIL -->|"activates"| Cancer
    Tumor{"Tumor"}
    TRAIL -->|"inhibits"| Tumor
    TRAIL -->|"inhibits"| Cancer
    Als{"Als"}
    TRAIL -->|"activates"| Als
    Ms{"Ms"}
    TRAIL -->|"activates"| Ms
    TRAIL -->|"activates"| Tumor
    CANCER["CANCER"]
    TRAIL -->|"inhibits"| CANCER
    Immune_Response(["Immune Response"])
    TRAIL -->|"inhibits"| Immune_Response
    INFLAMMATION["INFLAMMATION"]
    TRAIL -->|"activates"| INFLAMMATION
    RIPK1["RIPK1"]
    TRAIL -->|"activates"| RIPK1
    RIPK1 -->|"activates"| TRAIL
    JUN["JUN"]
    JUN -->|"activates"| TRAIL
    TERRA["TERRA"]
    TERRA -->|"activates"| TRAIL
    AMPK["AMPK"]
    AMPK -->|"activates"| TRAIL
    INFLAMMATION -->|"activates"| TRAIL
    CANCER -->|"activates"| TRAIL
    IFNG["IFNG"]
    IFNG -->|"inhibits"| TRAIL
    GENES["GENES"]
    GENES -->|"inhibits"| TRAIL
    MHC_I["MHC-I"]
    MHC_I -->|"causes"| TRAIL
    AND["AND"]
    AND -->|"activates"| TRAIL
    TRAF6["TRAF6"]
    TRAF6 -->|"activates"| TRAIL
    JNK["JNK"]
    JNK -->|"activates"| TRAIL
    style TRAIL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0