DR5

Understanding Entity Pages

This page aggregates everything SciDEX knows about DR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DR5 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, activates. Associated with ALS, Als, Breast Cancer. Connected to 59 entities in the SciDEX knowledge graph.

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graph TD
    DR5["<b>DR5</b>"]
    Cancer{"Cancer"}
    DR5 -->|"activates"| Cancer
    Tumor{"Tumor"}
    DR5 -->|"activates"| Tumor
    Als{"Als"}
    DR5 -->|"inhibits"| Als
    DR5 -->|"activates"| Als
    Lymphoma{"Lymphoma"}
    DR5 -->|"therapeutic target"| Lymphoma
    DR5 -->|"therapeutic target"| Als
    Ms{"Ms"}
    DR5 -->|"therapeutic target"| Ms
    DR5 -->|"therapeutic target"| Cancer
    ALS{"ALS"}
    DR5 -->|"inhibits"| ALS
    EGFR["EGFR"]
    DR5 -->|"activates"| EGFR
    BAD["BAD"]
    DR5 -->|"inhibits"| BAD
    Pi3K(["Pi3K"])
    DR5 -->|"inhibits"| Pi3K
    JUN["JUN"]
    JUN -->|"inhibits"| DR5
    ERK["ERK"]
    ERK -->|"inhibits"| DR5
    PI3K["PI3K"]
    PI3K -->|"inhibits"| DR5
    EGFR -->|"activates"| DR5
    BAD -->|"inhibits"| DR5
    AKT["AKT"]
    AKT -->|"activates"| DR5
    C_JUN["C-JUN"]
    C_JUN -->|"activates"| DR5
    P53["P53"]
    P53 -->|"therapeutic target"| DR5
    CANCER["CANCER"]
    CANCER -->|"therapeutic target"| DR5
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic target"| DR5
    style DR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0