concept

TAU TANGLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU TANGLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

269Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

TAU TANGLES is a concept in neurodegeneration research. Key relationships include: therapeutic target, inhibits, interacts with. Associated with Aging, Als, Alzheimer. Connected to 129 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TAU TANGLES
Key Genes/Proteins	APOE4, ALZHEIMER'S DISEASE, INFLAMMATION, NEUROINFLAMMATION
Related Diseases	Als, Alzheimer, Neurodegeneration, Inflammation, Neuroinflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TAU_TANGLES["<b>TAU TANGLES</b>"]
    TAU_TANGLES -->|"inhibits"| Alzheimer["Alzheimer"]
    TAU_TANGLES -->|"inhibits"| Ms["Ms"]
    TAU_TANGLES -->|"inhibits"| Dementia["Dementia"]
    TAU_TANGLES -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    TAU_TANGLES -->|"inhibits"| Als["Als"]
    TAU_TANGLES -->|"activates"| Aging["Aging"]
    TAU_TANGLES -->|"interacts"| Neuroinflammation["Neuroinflammation"]
    TAU_TANGLES -->|"interacts"| Inflammation["Inflammation"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| TAU_TANGLES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| TAU_TANGLES
    CDK1["CDK1"] -->|"inhibits"| TAU_TANGLES
    MICROGLIA["MICROGLIA"] -.protects against.-> TAU_TANGLES
    APOE3["APOE3"] -.protects against.-> TAU_TANGLES
    PSEN1["PSEN1"] -.protects against.-> TAU_TANGLES
    FERROPTOSIS["FERROPTOSIS"] -.protects against.-> TAU_TANGLES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"inhibits"| TAU_TANGLES
    MITOPHAGY["MITOPHAGY"] -->|"inhibits"| TAU_TANGLES
    ULK1["ULK1"] -->|"inhibits"| TAU_TANGLES
    AGING["AGING"] -->|"activates"| TAU_TANGLES
    ASTROCYTES["ASTROCYTES"] -->|"activates"| TAU_TANGLES

Outgoing (148)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.80
Alzheimer	inhibits	disease	0.75
Neurodegeneration	inhibits	disease	0.75
Als	inhibits	disease	0.75
Alzheimer	activates	disease	0.75
Inflammation	interacts_with	disease	0.75
Neuroinflammation	therapeutic_target	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
ALZHEIMER'S DISEASE	activates	gene	0.70
INFLAMMATION	interacts_with	gene	0.70
NEUROINFLAMMATION	therapeutic_target	gene	0.70
AMYLOID	inhibits	gene	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Ms	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	protects_against	disease	0.65
Dementia	inhibits	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Tauopathy	activates	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65

Incoming (121)

Source	Relation	Type	Str
APOE4	associated_with	gene	0.90
NEURODEGENERATION	inhibits	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
TAU	inhibits	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
PHAGOCYTOSIS	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CDK1	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
APOE3	protects_against	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PSEN1	protects_against	gene	0.60
FERROPTOSIS	protects_against	gene	0.60
MITOPHAGY	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
AGING	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMYLOID-Β PLAQUES	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
APOE4	interacts_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
WWOX	inhibits	gene	0.60
ERK	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NF-ΚB	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
TAU	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
TAU	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BACH1	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
CDK5	inhibits	gene	0.60
AND	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
APP	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TAU TANGLES

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

p-tau-217

Infectious Triggers in Alzheimer's Disease

Ferroptosis in Alzheimer's Disease

Traumatic Brain Injury and Neurodegeneration Pathway

Protein Aggregation Comparison in Neurodegeneration

Braak Staging and Tau Propagation Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

E2814 — Phase 2 for 4R-Tauopathy

Necroptotic Neurons

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Wallerian Degeneration

Etalanetug (E2814)

Longevity and Rejuvenation Therapies Landscape

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

WNT4 Gene

University of Oxford