concept

UBIQUITIN-PROTEASOME SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBIQUITIN-PROTEASOME SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

46Outgoing

8Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	UBIQUITIN-PROTEASOME SYSTEM
Key Genes/Proteins	NRF2, UBIQUITIN, VCP, ALPHA-SYNUCLEIN
Related Diseases	AUTOPHAGY, ROS, OXIDATIVE STRESS, DOPAMINE, MITOCHONDRIAL DYSFUNCTION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    UBIQUITIN_PROTEASOME_SYSTEM["UBIQUITIN-PROTEASOME SYSTEM"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Muscle_Protein_Degradation["Muscle Protein Degradation"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Proteostasis["Proteostasis"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involved_in"| Cancer_Hallmarks["Cancer Hallmarks"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"interacts"| Autophagy["Autophagy"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"mediates"| Muscle_Cell_Atrophy["Muscle Cell Atrophy"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"involves"| UBIQUITIN["UBIQUITIN"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"regulates"| protein_expression["protein expression"]
    UBIQUITIN_PROTEASOME_SYSTEM -->|"modulates"| protein_function["protein function"]
    P62["P62"] -->|"involved_in"| UBIQUITIN_PROTEASOME_SYSTEM
    UBIQUITIN -->|"component_of"| UBIQUITIN_PROTEASOME_SYSTEM
    E3_Ubiquitin_Ligases["E3 Ubiquitin Ligases"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Obestatin["Obestatin"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Proteolysis_Targeting_Chimeras["Proteolysis-Targeting Chimeras"] -->|"targets"| UBIQUITIN_PROTEASOME_SYSTEM
    OBESTATIN["OBESTATIN"] -->|"regulates"| UBIQUITIN_PROTEASOME_SYSTEM
    Autophagy_Deficiency["Autophagy Deficiency"] -->|"inhibits"| UBIQUITIN_PROTEASOME_SYSTEM

Outgoing (87)

Target	Relation	Type	Str
AUTOPHAGY	regulates	phenotype	0.65
DOPAMINE	participates_in	phenotype	0.55
AUTOPHAGY	associated_with	phenotype	0.45
UBIQUITIN	associated_with	protein	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
ALPHA-SYNUCLEIN	associated_with	protein	0.45
INFLAMMATION	associated_with	phenotype	0.45
KEAP1	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
TDP-43	associated_with	protein	0.45
SOD1	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
PROTEIN MISFOLDING	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
DEMENTIA	associated_with	disease	0.45
TAU	associated_with	protein	0.45
SENESCENCE	associated_with	phenotype	0.45
RAPAMYCIN	associated_with	drug	0.45
SQSTM1	associated_with	gene	0.45
MTOR	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
TP53	associated_with	gene	0.45
AKT	associated_with	gene	0.45
DOPAMINE	associated_with	phenotype	0.45
NEURON	associated_with	cell_type	0.45
CASP3	associated_with	gene	0.45
LAMP1	associated_with	gene	0.45
AMPK	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
CTSD	associated_with	gene	0.45
CTSB	associated_with	gene	0.45
MOTOR NEURONS	associated_with	cell_type	0.45
VCP	associated_with	gene	0.45
NEUROFIBRILLARY TANGLES	associated_with	phenotype	0.45
ER STRESS	associated_with	phenotype	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
C9orf72	associated_with	gene	0.45
TARDBP	associated_with	gene	0.45
TFEB	associated_with	gene	0.45

Incoming (34)

Source	Relation	Type	Str
NRF2	targets	gene	0.65
UBIQUITIN	targets	protein	0.65
ROS	activates	phenotype	0.65
OXIDATIVE STRESS	protects_against	phenotype	0.65
VCP	activates	gene	0.65
VCP	degrades	gene	0.65
VCP	participates_in	gene	0.55
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

UBIQUITIN-PROTEASOME SYSTEM

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

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Alzheimer's Disease Mechanism Index

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

HNRNPA2B1 Protein

Autophagy Mechanisms

ftd-tdp-pathology

Mitophagy Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Paraventricular Hypothalamic Nucleus (PVN) Neurons

LRRK2 Pathway in Parkinson's Disease

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

TDP-43 Proteinopathy

KARS1

Protein Aggregation Comparison in Neurodegeneration