How does hypothalamic JNK1 activation signal through the vagus nerve to upregulate hepatic lipogenic genes?

The study shows that hypothalamic JNK activation increases liver lipogenic gene expression via the vagus nerve, but the specific neural signaling mechanisms and molecular intermediates in this brain-liver axis remain unexplained. Understanding this pathway is crucial for developing targeted interventions for antipsychotic-induced metabolic dysfunction. Gap type: unexplained_observation Source paper: Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition. (None, None, PMID:37230004)