gene

CHR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

228Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CHR2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, co discussed. Associated with ALS, Aging, Als. Connected to 85 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	CHR2
Protein Type	Ion Channel
Target Class	Ion Channel
Function	CHR2 functions as a light-gated cation channel that opens in response to blue light (470nm), allowing depolarization through Na+ and Ca2+ influx. Therapeutic approaches would involve delivering CHR...
Mechanism of Action	CHR2 functions as a light-gated cation channel that opens in response to blue light (470nm), allowing depolarization through Na+ and Ca2+ influx. Therapeutic approaches would involve delivering CHR2 via gene therapy to degenerated neurons or photoreceptors, enabling light-dependent control of neural activity for vision restoration or neuromodulation applications.
Druggability	Low (0.33)
Clinical Stage	Phase II
Pathways	Hippocampal neurogenesis and synaptic plasticity
UniProt ID	A0FGR8
GeneCards	CHR2
Human Protein Atlas	CHR2
Associated Diseases	CANCER, DEPRESSION, Directional Neurite Outgrowth, neurodegeneration
Known Drugs/Compounds	Channelrhodopsin-2 activators
Interactions	BDNF, JUN, NGF, APP, STAR, EEF2
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Optogenetic Control of Mitochondrial Transfer Netw
KG Connections	196 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHR2 — AlphaFold A0FGR8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHR2["CHR2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CHR2["CHR2"] -->|"interacts"| BDNF["BDNF"]
    CHR2["CHR2"] -->|"co discussed"| CLOCK["CLOCK"]
    CHR2["CHR2"] -->|"co discussed"| CRH["CRH"]
    CHR2["CHR2"] -->|"co discussed"| BDNF_1["BDNF"]
    CHR2["CHR2"] -->|"co discussed"| SNCA["SNCA"]
    BDNF_2["BDNF"] -->|"interacts"| CHR2["CHR2"]
    FOXP3["FOXP3"] -->|"co discussed"| CHR2["CHR2"]
    TNFA["TNFA"] -->|"co discussed"| CHR2["CHR2"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| CHR2["CHR2"]
    style CHR2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
Neurite Outgrowth	promotes	phenotype	0.95
Dorsal Root Ganglia	expressed_in	cell_type	0.95
Directional Neurite Outgrowth	associated_with	phenotype	0.92
GABAergic Interneurons	targets	cell_type	0.90
Als	activates	disease	0.65
Aging	activates	disease	0.65
Stroke	activates	disease	0.65
Migraine	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Depression	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
BDNF	activates	gene	0.60
NGF	regulates	gene	0.60
JUN	activates	gene	0.60
NGF	activates	gene	0.60
neurodegeneration	implicated_in	disease	0.60
MTOR	activates	entity	0.60
APP	activates	gene	0.60
STAR	activates	gene	0.60
APP	therapeutic_target	gene	0.60
Rb	therapeutic_target	protein	0.60
EEF2	activates	gene	0.60
Calmodulin	activates	protein	0.60
Blood-Brain Barrier	activates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
AGING	regulates	gene	0.60
Amyloid	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
Innate Immunity	regulates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Amyloid	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
AGING	activates	gene	0.60
Mtor	activates	pathway	0.60
Autophagy	activates	pathway	0.60
AMYLOID-BETA	activates	gene	0.60
DEPRESSION	activates	entity	0.60
DEPRESSION	inhibits	entity	0.60
NEURON	activates	gene	0.60
STROKE	activates	gene	0.60
AND	activates	gene	0.60

Incoming (69)

Source	Relation	Type	Str
h-e0183502	targets_gene	hypothesis	0.90
h-826df660	targets_gene	hypothesis	0.90
h-e0183502	targets	hypothesis	0.80
BDNF	co_mentioned_with	gene	0.60
NGF	activates	gene	0.60
JUN	activates	gene	0.60
BDNF	activates	gene	0.60
BDNF	regulates	gene	0.60
STAR	activates	gene	0.60
APP	activates	gene	0.60
MTOR	activates	gene	0.60
APP	therapeutic_target	gene	0.60
EEF2	activates	gene	0.60
STROKE	activates	gene	0.60
NEURON	activates	gene	0.60
AMYLOID	regulates	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
DEPRESSION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AGING	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AGING	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60
AND	regulates	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AMYLOID-BETA	therapeutic_target	gene	0.60
CAMKII	activates	gene	0.60
GENES	activates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
BDNF	associated_with	gene	0.55
DEPRESSION	protects_against	disease	0.50
Autophagy	activates	process	0.50
autophagy	debate_co_mention	pathway	0.45
BDNF	debate_co_mention	gene	0.45
BMAL1	debate_co_mention	gene	0.45
BNIP3	debate_co_mention	gene	0.45
BNIP3/BNIP3L	debate_co_mention	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHR2

Understanding Entity Pages

Summary

Wiki Pages (20)

Device Therapies Comparison for CBS/PSP

CBS/PSP Treatment Rankings

Growth Factor Therapies

protective-strategies-cbs-psp

lithium-tauopathy

Parkinson's Disease Treatment

Circadian Rhythm Modulation Therapy

glp1-receptor-agonists

Mitochondrial Support Strategies for CBS/PSP

Section 103: Neurotrophic Factor Therapies in CBS/PSP

Biomarkers of Alzheimer Disease

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

PEX13 Gene

Biomarker-Therapeutic Development Nexus

BIN1 — Bridging Integrator 1

Ventral Pallidum GABAergic Neurons

Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSP

Vagus Nerve Stimulation for Parkinson's Disease

Biomarkers in Neurodegeneration