gene

STAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Gene: STAR encodes the steroidogenic acute regulatory protein, essential for neurosteroid synthesis and neuroprotection in neurodegenerative disease.

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🧬 Gene Info

Gene Symbol	STAR
Full Name	Steroidogenic Acute Regulatory Protein
Aliases	START1, STARD1
Chromosome	8p11.23
Function	Cholesterol accumulates at mitochondria-ER contact sites
Primary Expression	Brain (neurons, glia), adrenal gland, gonads
Amino Acids	285 aa
Pathways	Angiogenesis, Apoptosis, Mtor, Pi3K/Akt, Synaptic Plasticity
UniProt ID	P49675
NCBI Gene ID	6779
Ensembl ID	ENSG00000147548
GeneCards	STAR
Human Protein Atlas	STAR
C-terminal regulatory region	Contains phosphorylation sites
Associated Diseases	Aging, Als, Alzheimer, Cancer, Inflammation, Neurodegeneration
Interactions	AKT, ALZHEIMER, APOPTOSIS, App, ASTROCYTE, ASTROCYTES
KG Connections	175 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STAR — AlphaFold P49675 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

STAR — Steroidogenic Acute Regulatory Protein

gene · 749 words

→

Synaptic Therapy Alzheimer's Research Trial (START): A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease (NCT05531656)

clinical · 1758 words

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SL-START - SubLingual Apomorphine Schemes of TitrAtion in Real-world Treatment

clinical · 1457 words

→

Pathway Diagram

graph TD
    STAR["STAR"]
    Cancer{"Cancer"}
    STAR -->|"expressed in"| Cancer
    Als{"Als"}
    STAR -->|"expressed in"| Als
    STAR -->|"associated with"| Als
    STAR -->|"associated with"| Cancer
    ALS{"ALS"}
    STAR -->|"expressed in"| ALS
    STAR -->|"degrades"| ALS
    STAR -->|"activates"| ALS
    Neurodegeneration{"Neurodegeneration"}
    STAR -->|"activates"| Neurodegeneration
    Depression{"Depression"}
    STAR -->|"activates"| Depression
    Neurogenesis(["Neurogenesis"])
    STAR -->|"inhibits"| Neurogenesis
    Notch(["Notch"])
    STAR -->|"associated with"| Notch
    CD8["CD8"]
    STAR -->|"expressed in"| CD8
    CD8 -->|"expressed in"| STAR
    CD4["CD4"]
    CD4 -->|"expressed in"| STAR
    GAIN["GAIN"]
    GAIN -->|"inhibits"| STAR
    PP2A["PP2A"]
    PP2A -->|"associated with"| STAR
    CD4 -->|"associated with"| STAR
    CD8 -->|"associated with"| STAR
    BAX["BAX"]
    BAX -->|"expressed in"| STAR
    P53["P53"]
    P53 -->|"expressed in"| STAR
    SOD2["SOD2"]
    SOD2 -->|"activates"| STAR
    TCR["TCR"]
    TCR -->|"expressed in"| STAR
    ATP["ATP"]
    ATP -->|"inhibits"| STAR
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| STAR
    style STAR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (123)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.75
Als	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Depression	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	inhibits	disease	0.65
Insulin Resistance	inhibits	disease	0.65
ALS	degrades	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Alzheimer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	protects_against	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Neuroinflammation	implicated_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Synucleinopathy	implicated_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	implicated_in	disease	0.65
Aging	implicated_in	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Alzheimer's disease	interacts_with	disease	0.60
Mtor	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
NRF2	associated_with	gene	0.60
App	activates	protein	0.60
Rb	expressed_in	protein	0.60
Mek	inhibits	protein	0.60
ATP	inhibits	gene	0.60
NOTCH	associated_with	gene	0.60
Interleukin	expressed_in	protein	0.60
Oxidative Stress	interacts_with	pathway	0.60
Wnt	interacts_with	pathway	0.60
Neurogenesis	interacts_with	pathway	0.60
CD8	expressed_in	gene	0.60

Incoming (52)

Source	Relation	Type	Str
SEMAGLUTIDE	downregulates	drug	0.85
TNF	expressed_in	gene	0.60
AMPK	expressed_in	gene	0.60
INSULIN RESISTANCE	expressed_in	gene	0.60
BAX	inhibits	gene	0.60
CHR2	activates	gene	0.60
ROS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
CYP17A1	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
CD4	associated_with	gene	0.60
CD8	associated_with	gene	0.60
BAX	expressed_in	gene	0.60
SOD2	activates	gene	0.60
SIRT1	expressed_in	gene	0.60
TCR	expressed_in	gene	0.60
IL-18	expressed_in	gene	0.60
NOTCH	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
ATP	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
DEPRESSION	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP17A1	expressed_in	gene	0.60
IL-1	expressed_in	gene	0.60
CYP19A1	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
GAIN	inhibits	gene	0.60
PP2A	associated_with	gene	0.60
PP2A	expressed_in	entity	0.60
CD8	expressed_in	gene	0.60
PTEN	activates	gene	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
EGFR	activates	gene	0.60
NRF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	implicated_in	gene	0.60
PARKINSON	implicated_in	gene	0.60
ASTROCYTE	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
IL-6	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GLE1-Mediated mRNA Export Defect Creates Translation-Compete	0.823	als	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STAR in their description or question text

No additional research found