concept

EPOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

EPOR is a concept in neurodegeneration research. Key relationships include: regulates, contributes to, activates. Associated with ALS, Als, Leukemia. Connected to 70 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	EPOR
Key Genes/Proteins	TLR4, FGF8, CSF2, AKT, ISG15, CSF2RA
Related Diseases	Als, Leukemia, ALS
Related Pathways	Akt, Pi3K, Mapk
Linked Hypotheses	1 hypotheses

Wiki Pages (3)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EPOR["EPOR"]
    EPOR -->|"regulates"| Als["Als"]
    EPOR -->|"activates"| Leukemia["Leukemia"]
    EPOR -->|"regulates"| ALS["ALS"]
    EPOR -->|"regulates"| TLR4["TLR4"]
    EPOR -->|"regulates"| FGF8["FGF8"]
    EPOR -->|"regulates"| CSF2["CSF2"]
    EPOR -->|"regulates"| AKT["AKT"]
    EPOR -->|"regulates"| ISG15["ISG15"]
    ruxolitinib["ruxolitinib"] -->|"inhibits"| EPOR
    HSPA1A["HSPA1A"] -->|"regulates"| EPOR
    P38["P38"] -->|"regulates"| EPOR
    CXCL10["CXCL10"] -->|"regulates"| EPOR
    ERK["ERK"] -->|"regulates"| EPOR
    FGF2["FGF2"] -->|"regulates"| EPOR
    PI3K["PI3K"] -->|"regulates"| EPOR
    STAT1["STAT1"] -->|"regulates"| EPOR
    NAMPT["NAMPT"] -->|"regulates"| EPOR
    S100A8["S100A8"] -->|"regulates"| EPOR

Outgoing (72)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Leukemia	activates	disease	0.65
Als	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
TLR4	regulates	gene	0.60
FGF8	regulates	gene	0.60
CSF2	regulates	gene	0.60
AKT	regulates	gene	0.60
ISG15	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
Akt	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
CSF1R	contributes_to	gene	0.60
TYK2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
CXCL10	regulates	gene	0.60
EPO	regulates	gene	0.60
S100A8	regulates	gene	0.60
P38	regulates	gene	0.60
ERK	regulates	gene	0.60
NAMPT	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
STAT1	regulates	gene	0.60
BCL-2	regulates	gene	0.60
PI3K	regulates	gene	0.60
GENES	regulates	gene	0.60
FGF2	regulates	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
TSLP	contributes_to	gene	0.60
GENES	activates	gene	0.60
JAK2	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
ABL2	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
ETV6	expressed_in	gene	0.60
ABL1	contributes_to	gene	0.60
MAPK	regulates	gene	0.60
AND	regulates	gene	0.60
AND	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
CRLF2	contributes_to	gene	0.60
LGALS9	regulates	gene	0.60
Neutrophil	regulates	cell_type	0.60
Interferon	regulates	protein	0.60
Cytokine	regulates	protein	0.60
B Cell	activates	cell_type	0.60
Cytokine	activates	protein	0.60

Incoming (52)

Source	Relation	Type	Str
ruxolitinib	inhibits	drug	0.64
HSPA1A	regulates	gene	0.60
P38	regulates	gene	0.60
CXCL10	regulates	gene	0.60
ERK	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
STAT1	regulates	gene	0.60
NAMPT	regulates	gene	0.60
S100A8	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL-2	regulates	gene	0.60
ABL2	contributes_to	gene	0.60
NTRK3	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
ETV6	expressed_in	gene	0.60
ABL1	contributes_to	gene	0.60
PDGFRB	contributes_to	gene	0.60
GENES	activates	gene	0.60
JAK2	contributes_to	gene	0.60
AKT	regulates	gene	0.60
CSF1R	contributes_to	gene	0.60
TLR4	regulates	gene	0.60
ISG15	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
CSF2	regulates	gene	0.60
FGF8	regulates	gene	0.60
EPO	regulates	gene	0.60
TYK2	contributes_to	gene	0.60
LGALS9	regulates	gene	0.60
CRLF2	contributes_to	gene	0.60
IL7R	contributes_to	gene	0.60
FLT3	contributes_to	gene	0.60
TSLP	contributes_to	gene	0.60
ABL2	activates	gene	0.60
CRLF2	activates	gene	0.60
ABL2	expressed_in	gene	0.60
dasatinib	targets	drug	0.60
PDGFRB	activates	gene	0.50
IL7R	activates	gene	0.50
CSF1R	activates	gene	0.50
TYK2	activates	gene	0.50
JAK2	activates	gene	0.50
NTRK3	activates	gene	0.50
PTK2B	activates	gene	0.50
ABL1	activates	protein	0.50
FLT3	activates	protein	0.50
PDGFRB	expressed_in	gene	0.50
CSF1R	expressed_in	gene	0.50
JAK2	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EPOR

Understanding Entity Pages

Summary

Wiki Pages (3)

JAK-STAT Signaling Pathway in Neurodegeneration

Erythropoietin Signaling Pathway in Neurodegeneration

SOCS3 - Suppressor of Cytokine Signaling 3

Pathway Diagram

Outgoing (72)

Incoming (52)

Targeting Hypotheses (0)

Mentioning Analyses (5)

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What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Related Papers (0)