Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MCT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MCT1 |
| Pathways | Energy Metabolism, Tumor Cell Metabolism, unfolded protein response, oxidative stress response, blood-brain barrier |
| GeneCards | MCT1 |
| Human Protein Atlas | MCT1 |
| Associated Diseases | ALS, dementia, glioblastoma |
| Known Drugs/Compounds | LACTATE, BHBA, metformin |
| Interactions | RNA, SLC16A1, SLC16A3, TNF, PS1, STAT3 |
| KG Connections | 86 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MCT1["MCT1"] -->|"catalyzes"| L_lactate["L-lactate"]
style L_lactate fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"interacts"| BASIGIN["BASIGIN"]
style BASIGIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"catalyzes"| Pyruvate["Pyruvate"]
style Pyruvate fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"involved in"| Energy_Metabolism["Energy Metabolism"]
style Energy_Metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"involved in"| T_Lymphocyte_Activation["T-Lymphocyte Activation"]
style T_Lymphocyte_Activation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"expressed in"| Brain["Brain"]
style Brain fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
MCT1["MCT1"] -->|"mediates"| Water_Transport["Water Transport"]
style Water_Transport fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
SLC16A1["SLC16A1"] -->|"encodes"| MCT1["MCT1"]
style SLC16A1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style MCT1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| L-lactate | catalyzes | compound | 1.00 |
| BASIGIN | interacts_with | protein | 1.00 |
| Pyruvate | catalyzes | compound | 1.00 |
| L-Lactate | transports | compound | 1.00 |
| Pyruvate | transports | compound | 1.00 |
| Ketone Bodies | transports | compound | 1.00 |
| Basigin | interacts_with | protein | 1.00 |
| Embigin | interacts_with | protein | 1.00 |
| Energy Metabolism | involved_in | pathway | 0.95 |
| l-lactate transport | mediates | process | 0.95 |
| T-Lymphocyte Activation | involved_in | process | 0.90 |
| Brain | expressed_in | cell_type | 0.90 |
| Tumor Cell Metabolism | involved_in | pathway | 0.90 |
| Cancer | therapeutic_target | disease | 0.85 |
| brain energy metabolism | involved_in | pathway | 0.85 |
| skeletal muscle energy metabolism | involved_in | pathway | 0.85 |
| Ketogenic Diet | upregulates | drug | 0.85 |
| Water Transport | mediates | process | 0.80 |
| neurons | expressed_in | cell_type | 0.75 |
| endothelial cells | expressed_in | cell_type | 0.70 |
| unfolded protein response | participates_in | pathway | 0.65 |
| oxidative stress response | participates_in | pathway | 0.65 |
| blood-brain barrier | participates_in | pathway | 0.65 |
| LACTATE | interacts_with | drug | 0.60 |
| BHBA | interacts_with | drug | 0.60 |
| AMPK | associated_with | protein | 0.60 |
| TUMOR PROGRESSION | contributes_to | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| glioblastoma | associated_with | disease | 0.60 |
| dementia | associated_with | disease | 0.60 |
| SLC16A1 | expressed_in | gene | 0.60 |
| SLC16A1 | implicated_in | gene | 0.60 |
| SLC16A3 | implicated_in | gene | 0.60 |
| TJP1 | activates | gene | 0.60 |
| glioblastoma | expressed_in | disease | 0.60 |
| Notch signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| PDH | activates | gene | 0.60 |
| astrocytes | expressed_in | cell_type | 0.55 |
| SLC16A1 | associated_with | gene | 0.55 |
| SLC16A3 | associated_with | gene | 0.55 |
| RNA | activates | gene | 0.55 |
| SLC16A1 | activates | gene | 0.55 |
| SLC16A3 | activates | gene | 0.55 |
| Alzheimer's disease | activates | disease | 0.55 |
| TNF | activates | gene | 0.55 |
| complement cascade | participates_in | pathway | 0.55 |
| synaptic plasticity | participates_in | pathway | 0.55 |
| PS1 | activates | gene | 0.55 |
| SLC16A1 | regulates | gene | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC16A1 | encodes | gene | 1.00 |
| PAL | upregulates | compound | 0.85 |
| SLC16A1 | interacts_with | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| HMGCR | expressed_in | gene | 0.60 |
| GAT1 | translocates_to | gene | 0.60 |
| IDH1 | interacts_with | gene | 0.60 |
| LDHA | interacts_with | gene | 0.60 |
| GBM | expressed_in | gene | 0.60 |
| IDH1 | expressed_in | gene | 0.60 |
| LDHA | expressed_in | gene | 0.60 |
| HMGCS2 | interacts_with | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| LDHA | activates | gene | 0.60 |
| GFAP | activates | gene | 0.55 |
| GFAP | associated_with | gene | 0.55 |
| APP | activates | gene | 0.55 |
| GFAP | regulates | gene | 0.55 |
| GFAP | inhibits | gene | 0.55 |
| JAK | inhibits | gene | 0.55 |
| AHR | activates | gene | 0.55 |
| AMPK | activates | gene | 0.55 |
| metformin | targets | drug | 0.55 |
| GBM | co_expressed_with | gene | 0.50 |
| ATP | co_expressed_with | protein | 0.50 |
| HK2 | co_expressed_with | gene | 0.50 |
| HMGCS2 | associated_with | gene | 0.35 |
| SLC16A1 | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D | 0.614 | neurodegeneration | What is the molecular mechanism by which |
| Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli | 0.455 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.614
neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Preventive Effects of Probiotic Formula on Metabolic Stress Associated Physical [PMID:41958144] | Song JG, Bae HJ, Lee DH, Seo J, Lee B et | J Microbiol Biotechnol | 2026 | 0 |
| Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based [PMID:40507957] | Terzi A, Maqoud F, Guido D, Mallardi D, | International journal of molec | 2025 | 0 |
| Direct mitochondrial import of lactate supports resilient carbohydrate oxidation [PMID:39416192] | Cluntun AA, Visker JR, Velasco-Silva JN, | bioRxiv : the preprint server | 2024 | 0 |
| Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhib [PMID:36584238] | Puri S, Stefan K, Khan SL, Pahnke J, Ste | Journal of medicinal chemistry | 2023 | 0 |
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science (New York, N.Y.) | 2023 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| SLC gene mutations and pediatric neurological disorders: diverse clinical phenot [PMID:34797406] | Mir A, Almudhry M, Alghamdi F, Albaradie | Human genetics | 2022 | 0 |
| Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptak [PMID:35177691] | Hascup ER, Sime LN, Peck MR, Hascup KN | Scientific reports | 2022 | 0 |
| Editor's Review and Introduction: Cognition-Inspired Artificial Intelligence. [PMID:35853452] | Cassenti DN, Veksler VD, Ritter FE | Topics in cognitive science | 2022 | 0 |
| Innovations in systemic sclerosis. [PMID:34483059] | Johnson SR | Best practice & research. Clin | 2021 | 0 |
| Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration [PMID:34491913] | Jha MK, Passero JV, Rawat A, Ament XH, Y | The Journal of clinical invest | 2021 | 0 |
| Genome sequencing analysis identifies new loci associated with Lewy body dementi [PMID:33589841] | Chia R, Sabir MS, Bandres-Ciga S, Saez-A | Nature genetics | 2021 | 0 |
| Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] | Yadav P, Antony-Babu S, Hayes E, Healy O | Microbiology resource announce | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibi [PMID:31605138] | Avitabile M, Succoio M, Testori A, Cardi | Carcinogenesis | 2020 | 0 |
| Manassantin B shows antiviral activity against coxsackievirus B3 infection by ac [PMID:31253850] | Song JH, Ahn JH, Kim SR, Cho S, Hong EH, | Scientific reports | 2019 | 0 |
| Brain Glucose Metabolism: Integration of Energetics with Function. [PMID:30565508] | Dienel GA | Physiological reviews | 2019 | 0 |
| A ketogenic drink improves brain energy and some measures of cognition in mild c [PMID:31027873] | Fortier M, Castellano CA, Croteau E, Lan | Alzheimer's & dementia : the j | 2019 | 0 |
| Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms an [PMID:28778403] | Koschmieder S, Vetrie D | Seminars in cancer biology | 2018 | 0 |