concept

LACTATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LACTATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

145Connections

3Hypotheses

1Analyses

50Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LACTATE
Key Genes/Proteins	P300, HK2, CD47, SIRT1
Related Diseases	GLYCOLYSIS, AGING, CANCER
Related Pathways	WNT SIGNALING, MAPK PATHWAY
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    LACTATE["LACTATE"]
    LACTATE -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    LACTATE -->|"modulates"| RAB7A["RAB7A"]
    LACTATE -->|"promotes"| CIRP["CIRP"]
    LACTATE -->|"regulates"| HADHA["HADHA"]
    LACTATE -->|"mediates"| Histone_Lactylation["Histone Lactylation"]
    LACTATE -->|"promotes"| Metastasis["Metastasis"]
    LDHA["LDHA"] -->|"regulates"| LACTATE
    SIRT1["SIRT1"] -->|"modulates"| LACTATE
    HK2["HK2"] -->|"regulates"| LACTATE
    ischemia_reperfusion_injury["ischemia-reperfusion injury"] -->|"activates"| LACTATE
    MCT1["MCT1"] -->|"interacts"| LACTATE

Outgoing (95)

Target	Relation	Type	Str
GLYCOLYSIS	activates	phenotype	0.65
P300	activates	gene	0.65
HK2	inhibits	gene	0.65
HK2	treats	gene	0.65
AGING	regulates	phenotype	0.65
WNT SIGNALING	inhibits	pathway	0.65
CD47	activates	gene	0.65
CD47	causes	gene	0.65
CD47	regulates	gene	0.65
BEVACIZUMAB	activates	drug	0.65
SIRT1	regulates	gene	0.65
CANCER	activates	disease	0.65
MAPK PATHWAY	activates	pathway	0.65
CANCER	regulates	disease	0.65
CANCER	exacerbates	disease	0.65
CELL DEATH	biomarker_for	phenotype	0.65
CELL DEATH	produces	phenotype	0.65
TUMOR GROWTH	activates	phenotype	0.65
PI3K	activates	gene	0.65
PI3K	inhibits	gene	0.65
PYRUVATE	produces	phenotype	0.65
GLYCOLYSIS	regulates	phenotype	0.65
ERK	exacerbates	gene	0.65
ASTROCYTE	inhibits	cell_type	0.65
CA1	activates	brain_region	0.65
GLIOBLASTOMA	activates	disease	0.65
INFLAMMATION	regulates	phenotype	0.65
MACROPHAGES	protects_against	cell_type	0.65
NLRP3 INFLAMMASOME	regulates	pathway	0.65
ATP	activates	phenotype	0.65
VEGFA	causes	gene	0.65
MACROPHAGE	activates	cell_type	0.65
BDNF	activates	gene	0.65
BDNF	interacts_with	gene	0.65
ATP	produces	phenotype	0.65
STAT3	causes	gene	0.65
AUTOPHAGY	activates	phenotype	0.65
EPIGENETIC DYSREGULATION	regulates	phenotype	0.65
SCHIZOPHRENIA	regulates	disease	0.65
SIRT1	activates	protein	0.64
PYRUVATE	converts	phenotype	0.60
NEURON	treats	cell_type	0.60
APP	protects_against	gene	0.60
GLYCOLYSIS	stabilizes	phenotype	0.60
NEURONS	produces	cell_type	0.60
NEURONS	activates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
GLYCOLYSIS	expressed_in	phenotype	0.55
STROKE	expressed_in	disease	0.55

Incoming (50)

Source	Relation	Type	Str
PYRUVATE	causes	phenotype	0.65
PKM2	causes	gene	0.65
LAG3	inhibits	gene	0.65
WARBURG EFFECT	causes	phenotype	0.65
ERK	phosphorylates	gene	0.65
TUMOR MICROENVIRONMENT	interacts_with	phenotype	0.65
GLIOMA	interacts_with	disease	0.65
IDH1	produces	gene	0.65
LRP1	inhibits	gene	0.65
SIRT1	interacts_with	gene	0.65
SIRT1	causes	gene	0.65
STAT3	activates	gene	0.65
STAT3	regulates	gene	0.65
AMPK	treats	gene	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65
MCT1	interacts_with	protein	0.60
GLYCOLYSIS	causes	phenotype	0.60
OXIDATIVE STRESS	synergizes_with	phenotype	0.60
APP	targets	gene	0.60
LDHA	activates	gene	0.60
HK2	causes	gene	0.60
AMPK	protects_against	gene	0.60
AMPK	causes	gene	0.60
NEURODEGENERATION	treats	phenotype	0.60
GLYCOLYSIS	produces	phenotype	0.60
GLUTAMATE	activates	phenotype	0.60
ASTROCYTE	targets	cell_type	0.60
ASTROCYTE	treats	cell_type	0.60
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
AMPK SIGNALING	associated_with	pathway	0.50
WHITE MATTER	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
GRAY MATTER	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.50
WNT SIGNALING	associated_with	pathway	0.45
BEVACIZUMAB	associated_with	drug	0.45
MAPK PATHWAY	associated_with	pathway	0.45
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
QUERCETIN	associated_with	drug	0.45
SEMAGLUTIDE	associated_with	drug	0.45

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.486	translational neuroscience	Which metabolic biomarkers can distingui
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener	0.412	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.614

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772]	Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand	Mol Ther	2025	1
Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035]	Guillén-Yunta M, García-Aldea Á, Valcárc	Neurobiol Dis	2024	1
The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875]	Halestrap AP	Mol Aspects Med	2013	1
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Tiratricol: First Approval. [PMID:40549098]	["Lamb Y"]	Drugs	2025	0
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. [PMID:40680733]	Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel	Cell	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 [PMID:39934699]	Maculewicz E, Mastalerz A, Garbacz A, Mr	BMC genomics	2025	0
Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Tow [PMID:37094775]	["Zorec R", "Vardjan N"]	Neurobiology of disease	2023	0
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. [PMID:36150888]	Wasserman-Bartov T, Admati I, Lebenthal-	The Journal of neuroscience :	2022	0
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. [PMID:34097251]	Sohrabi E, Moslemi M, Rezaie E, Nafissi	Genes & genomics	2021	0
Thyroid Hormone Transporters. [PMID:31754699]	["Groeneweg S", "van Geest F", "Peeters	Endocrine reviews	2020	0
Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis [PMID:31797746]	["Admati I", "Wasserman-Bartov T", "Tovi	Thyroid : official journal of	2020	0
Disease characteristics of MCT8 deficiency: an international, retrospective, mul [PMID:32559475]	Groeneweg S, van Geest FS, Abacı A, Alca	The lancet. Diabetes & endocri	2020	0
Nonbiological maternal risk factor for low birth weight on Latin America: a syst [PMID:23386023]	["da Silva T"]	Einstein (Sao Paulo, Brazil)	2012	0
Thyroid hormone transporters in the brain. [PMID:20879691]	Braun D, Wirth EK, Schweizer U	Reviews in the neurosciences	2010	0
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome [PMID:16849530]	["Eckerdt F", "Strebhardt K"]	Cancer research	2006	0

LACTATE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Novel Therapy Index

Astrocyte Reactivity Mechanism

Mitochondrial Dysfunction in Parkinson's Disease

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Oligodendrocytes

cerebral-cortical-vasal-neurons

rankings

Blood-Brain Barrier Biology and Crossing Strategies

Coenzyme Q10 for Neurodegeneration

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

deferiprone-neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

Glia-Neuron Crosstalk in Alzheimer's Disease

Astrocytes

Neuroinflammation-Mitochondria Crosstalk Pathway