concept

B CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	B CELLS
Key Genes/Proteins	NF-KB, MOG, AQP4, CXCL10, BDNF
Related Diseases	LYMPHOMA, ROS, AGING
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    B_CELLS["B CELLS"]
    B_CELLS -->|"mediates"| Tolerance_To_AQP4["Tolerance To AQP4"]
    B_CELLS -->|"activates"| NF_KB["NF-KB"]
    B_CELLS -->|"regulates"| Immune_Tolerance["Immune Tolerance"]
    B_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    B_CELLS -->|"regulates"| AQP4["AQP4"]
    B_CELLS -->|"involved_in"| Neuromyelitis_Optica["Neuromyelitis Optica"]
    DDX5["DDX5"] -->|"regulates"| B_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| B_CELLS
    AQP4 -->|"activates"| B_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| B_CELLS
    AKT["AKT"] -->|"activates"| B_CELLS

Outgoing (96)

Target	Relation	Type	Str
NF-KB	activates	gene	0.95
LYMPHOMA	activates	disease	0.80
T CELLS	interacts_with	cell_type	0.80
MACROPHAGES	treats	cell_type	0.70
T CELLS	activates	cell_type	0.65
LYMPHOMA	interacts_with	disease	0.65
LYMPHOMA	regulates	disease	0.65
INFLAMMATION	activates	process	0.65
LYMPHOMA	inhibits	disease	0.65
LYMPHOMA	depleted_in	disease	0.55
MULTIPLE SCLEROSIS	implicated_in	disease	0.55
BCL2	interacts_with	gene	0.50
BAX	interacts_with	gene	0.50
IL-6	activates	gene	0.50
CASP3	activates	gene	0.50
BCL2	activates	gene	0.50
ENDOTHELIAL CELLS	interacts_with	cell_type	0.50
FIBROBLASTS	interacts_with	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
LYMPHOMA	associated_with	disease	0.50
DENDRITIC CELLS	associated_with	concept	0.50
PURINERGIC SIGNALING	regulates	process	0.35
IL-6	inhibits	gene	0.35
COMPLEMENT	inhibits	protein	0.35
FOXO1	interacts_with	gene	0.35
NICOTINAMIDE	activates	drug	0.35
MYC	activates	gene	0.35
HEPATOCELLULAR CARCINOMA	activates	disease	0.35
OXIDATIVE STRESS	activates	process	0.35
RAPAMYCIN	activates	drug	0.35
MTOR	activates	gene	0.35
PI3K	activates	gene	0.35
NRF2	activates	gene	0.35
VEGF	activates	gene	0.35
CREB	activates	gene	0.35
FIS1	activates	gene	0.35
P53	activates	gene	0.35
BAX	activates	gene	0.35
STAT3	activates	gene	0.35
PERICYTES	interacts_with	cell_type	0.35
LEUKEMIA	activates	disease	0.35
GFAP	activates	gene	0.35
DENDRITIC CELLS	implicated_in	cell_type	0.35
MACROPHAGES	implicated_in	cell_type	0.35
MAPK	activates	gene	0.35
IL-10	activates	gene	0.35
GLIOBLASTOMA	interacts_with	disease	0.35
CD8	interacts_with	gene	0.35
CANCER	associated_with	disease	0.35
MACROPHAGES	interacts_with	cell_type	0.35

Incoming (112)

Source	Relation	Type	Str
MOG	exacerbates	gene	0.70
AQP4	treats	gene	0.65
CXCL10	activates	gene	0.65
ROS	activates	phenotype	0.65
AGING	activates	phenotype	0.65
BDNF	activates	gene	0.65
AGING	participates_in	phenotype	0.55
APOPTOSIS	activates	process	0.50
AQP4	associated_with	gene	0.50
CD40	activates	gene	0.50
T Cell	activates	cell_type	0.50
T CELLS	activates	concept	0.50
AQP4	interacts_with	gene	0.50
CD40	interacts_with	gene	0.50
disease	interacts_with	disease	0.50
CD19	inhibits	gene	0.50
IL-6R	inhibits	protein	0.50
COMPLEMENT	inhibits	pathway	0.50
B Cell	associated_with	cell_type	0.50
ST6GAL1	associated_with	concept	0.50
FUT8	associated_with	concept	0.50
SARS	regulates	gene	0.50
Myeloma	activates	disease	0.50
GENE EXPRESSION	activates	concept	0.50
CCR6	expressed_in	gene	0.50
B Cell	expressed_in	cell_type	0.50
GENE EXPRESSION	expressed_in	concept	0.50
DICER1	interacts_with	gene	0.50
B Cell	interacts_with	cell_type	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
Lymphoma	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
inflammation	activates	pathway	0.50
B Cell	activates	cell_type	0.50
Immunotherapy	activates	process	0.50
Proteins	inhibits	protein	0.50
Fibroblast	associated_with	cell_type	0.50
ENDOTHELIAL	associated_with	concept	0.50
T CELLS	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
Macrophage	associated_with	cell_type	0.50
NF-κB	activates	concept	0.50
Toll-Like Receptor	activates	pathway	0.50
T CELLS	inhibits	concept	0.50
MACROPHAGES	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
NEUTROPHIL	activates	cell_type	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.612	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

B CELLS

Understanding Entity Pages

Wiki Pages (20)

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