concept

TNF-ALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNF-ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

169Connections

0Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

12Debates

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💡 Concept Info

Name	TNF-ALPHA
Key Genes/Proteins	ACTB, Actin, AGING, AIF1, ANG, APOPTOSIS
Related Diseases	Addiction, Aging, Als, ALS
Related Pathways	Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TNF-alpha Protein - Tumor Necrosis Factor

protein · 797 words

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Pathway Diagram

graph TD
    TNF_ALPHA["TNF-ALPHA"]
    style TNF_ALPHA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    TNF_ALPHA -->|"activates"| apoptosis(apoptosis)
    TNF_ALPHA -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
    TNF_ALPHA -->|"upregulates"| Oxidative_Stress["Oxidative Stress"]
    TNF_ALPHA -.->|"inhibits"| Depression["Depression"]
    TNF_ALPHA -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    TNF_ALPHA -->|"regulates"| Parkinson["Parkinson"]
    TNF_ALPHA -.->|"inhibits"| Aging["Aging"]
    TNF_ALPHA -->|"regulates"| Tumor["Tumor"]
    TNF_ALPHA -.->|"inhibits"| ALS["ALS"]
    TNF_ALPHA -.->|"inhibits"| Inflammation["Inflammation"]
    ADAM17([ADAM17]) -->|"activates"| TNF_ALPHA
    Etanercept{"Etanercept"} -.->|"inhibits"| TNF_ALPHA
    etanercept{"etanercept"} -.->|"inhibits"| TNF_ALPHA
    CD40["CD40"] -->|"upregulates"| TNF_ALPHA
    AIF1([AIF1]) -->|"regulates"| TNF_ALPHA
    ATG5([ATG5]) -->|"regulates"| TNF_ALPHA
    ATG7([ATG7]) -->|"regulates"| TNF_ALPHA
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| TNF_ALPHA
    BECN1([BECN1]) -->|"regulates"| TNF_ALPHA
    CASP1([CASP1]) -->|"regulates"| TNF_ALPHA

Outgoing (90)

Target	Relation	Type	Str
Neuroinflammation	involved_in	process	0.90
apoptosis	activates	phenotype	0.90
Neuroinflammation	mediates	process	0.85
Temporal Lobe Epilepsy	contributes_to	disease	0.80
Oxidative Stress	upregulates	process	0.80
INTRACEREBRAL HEMORRHAGE	associated_with	disease	0.80
AQP4	regulates	gene	0.70
ACSL4 expression	activates	gene	0.70
complement gene expression	activates	process	0.70
neuroinflammation	associated_with	phenotype	0.70
ACSL4	regulates	gene	0.70
dopaminergic neuron damage	causes	phenotype	0.70
Addiction	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Aging	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
ALS	inhibits	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Depression	inhibits	disease	0.65
HPA AXIS RELATED GENES	associated_with	gene	0.60
Hypersexual Disorder	associated_with	disease	0.60
GENES	associated_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
CRH	associated_with	gene	0.60
TNF	regulates	gene	0.60
ACTB	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
ASC	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
GFAP	inhibits	gene	0.60
SNCA	regulates	gene	0.60
AIF1	inhibits	gene	0.60
GAPDH	inhibits	gene	0.60
CASP1	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
IBA1	inhibits	gene	0.60
Neuroinflammatory	inhibits	pathway	0.60
Inflammasome	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
ATG7	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
LC3B	regulates	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
BECN1	inhibits	gene	0.60

Incoming (79)

Source	Relation	Type	Str
ADAM17	activates	protein	0.90
etanercept	inhibits	drug	0.85
Etanercept	inhibits	drug	0.85
gingipain cysteine proteases	degrades	protein	0.80
ANTHOCYANINS	inhibits	compound	0.80
Celastrol	suppresses	gene	0.80
ABETA	upregulates	protein	0.80
sesquiterpenoids	downregulates	compound	0.75
Senescent Astrocytes	associated_with	cell_type	0.70
IL6	regulates	gene	0.65
AIF1	regulates	gene	0.65
ATG5	regulates	gene	0.65
ATG7	regulates	gene	0.65
BECN1	regulates	gene	0.65
CASP1	regulates	gene	0.65
DOPAMINERGIC	regulates	cell_type	0.65
GFAP	regulates	gene	0.65
IBA1	regulates	gene	0.65
IL1B	regulates	gene	0.65
NEURON	regulates	cell_type	0.65
NEURONS	regulates	cell_type	0.65
NLRP3	expressed_in	gene	0.65
PARKIN	expressed_in	gene	0.65
PARKINSON	expressed_in	disease	0.65
TH	regulates	gene	0.65
MICROGLIA	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
BCL2	activates	gene	0.60
BECN1	inhibits	gene	0.60
SNCA	regulates	gene	0.60
ATG5	inhibits	gene	0.60
ACTB	inhibits	gene	0.60
RNA	activates	gene	0.60
GFAP	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
NR3C1	associated_with	gene	0.60
JUN	associated_with	gene	0.60
CYLD	activates	gene	0.60
RIPK1	activates	gene	0.60
SMAC	inhibits	gene	0.60
FADD	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
IL-6	inhibits	gene	0.60
FKBP5	associated_with	gene	0.60
CRHBP	associated_with	gene	0.60
CASP1	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
IBA1	inhibits	gene	0.60