protein

CDK12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

24Outgoing

18Incoming

0Experiments

0Debates

Summary

CDK12 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with Cancer, Ms, Tumor. Connected to 25 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CDK12
Full Name	Cyclin-Dependent Kinase 12
Protein Type	Kinase
Function	CDK12 is a serine/threonine kinase that forms a complex with cyclin K to phosphorylate the C-terminal domain (CTD) of RNA polymerase II.
Primary Expression	all CA regions - Motor Cortex: High expression in upper motor neurons - Spinal Cord: Present in motor neurons - Cerebellum: Moderate expre
Molecular Weight	164 kDa
Pathways	Autophagy, Epigenetic
Ensembl ID	ENSG00000167258
GeneCards	CDK12
Human Protein Atlas	CDK12
Kinase Domain	C-terminal serine/threonine kinase domain
Cyclin-Binding Region	N-terminal region for cyclin K interaction
RS-Rich Region	Arginine-serine rich region involved in RNA processing
Associated Diseases	PULMONARY_FUNCTION
Interactions	ARAF, ATG12, ATG16L1, ATG3, ATG7, ATG9A
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK12 — Cyclin-Dependent Kinase 12

gene · 889 words

→

CDK12 Protein

protein · 672 words

→

Pathway Diagram

graph TD
    CDK12["CDK12"]
    Cancer{"Cancer"}
    CDK12 -->|"activates"| Cancer
    Ms{"Ms"}
    CDK12 -->|"inhibits"| Ms
    Tumor{"Tumor"}
    CDK12 -->|"therapeutic target"| Tumor
    CDK12 -->|"inhibits"| Cancer
    ATG3["ATG3"]
    CDK12 -->|"activates"| ATG3
    CANCER["CANCER"]
    CDK12 -->|"activates"| CANCER
    ATG7["ATG7"]
    CDK12 -->|"activates"| ATG7
    AUTOPHAGY["AUTOPHAGY"]
    CDK12 -->|"activates"| AUTOPHAGY
    CDK4["CDK4"]
    CDK12 -->|"activates"| CDK4
    ATG16L1["ATG16L1"]
    CDK12 -->|"activates"| ATG16L1
    LC3["LC3"]
    CDK12 -->|"activates"| LC3
    Epigenetic(["Epigenetic"])
    CDK12 -->|"activates"| Epigenetic
    ATG9A["ATG9A"]
    ATG9A -->|"activates"| CDK12
    ARAF["ARAF"]
    ARAF -->|"activates"| CDK12
    BECLIN1["BECLIN1"]
    BECLIN1 -->|"activates"| CDK12
    ATG12["ATG12"]
    ATG12 -->|"activates"| CDK12
    MYC["MYC"]
    MYC -->|"activates"| CDK12
    GENES["GENES"]
    GENES -->|"inhibits"| CDK12
    ENDOGENOUS_DNA["ENDOGENOUS DNA"]
    ENDOGENOUS_DNA -->|"expressed in"| CDK12
    MYC -->|"inhibits"| CDK12
    CANCER -->|"inhibits"| CDK12
    style CDK12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (24)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK12	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Akt	biomarker_for	pathway	0.60
CANCER	biomarker_for	gene	0.60
Pi3K	biomarker_for	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Epigenetic	activates	pathway	0.60
Autophagy	activates	pathway	0.60
DNA	inhibits	gene	0.60
CANCER	activates	gene	0.60
ATG3	activates	gene	0.60
ATG7	activates	gene	0.60
CDK4	activates	gene	0.60
ATG16L1	activates	gene	0.60
LC3	activates	gene	0.60
AKT	biomarker_for	gene	0.60
PULMONARY_FUNCTION	associated_with	phenotype	0.56

Incoming (18)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK12	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ATG9A	activates	gene	0.60
ARAF	activates	gene	0.60
BECLIN1	activates	gene	0.60
ATG12	activates	gene	0.60
MYC	activates	gene	0.60
PTEN	expressed_in	gene	0.60
PI3K	biomarker_for	gene	0.60
BRCA2	expressed_in	gene	0.60
RANK	biomarker_for	gene	0.60
TP53	expressed_in	gene	0.60
RB1	biomarker_for	gene	0.60
GENES	inhibits	gene	0.60
ENDOGENOUS DNA	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
ATM	expressed_in	gene	0.60
MYC	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK12 in their description or question text

No additional research found