concept

ENDOGENOUS DNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOGENOUS DNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections

0Hypotheses

0Analyses

50Outgoing

24Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ENDOGENOUS DNA
Key Genes/Proteins	GENES, DNA
Related Diseases	Senescence, Als, Ms, Inflammation, Autoimmune

Wiki Pages (17)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ENDOGENOUS_DNA["ENDOGENOUS DNA"]
    ENDOGENOUS_DNA -->|"activates"| cGAS["cGAS"]
    ENDOGENOUS_DNA -->|"activates"| GENES["GENES"]
    ENDOGENOUS_DNA -->|"activates"| DNA["DNA"]
    ENDOGENOUS_DNA -->|"activates"| Senescence["Senescence"]
    ENDOGENOUS_DNA -->|"activates"| Als["Als"]
    ENDOGENOUS_DNA -->|"activates"| Ms["Ms"]
    ENDOGENOUS_DNA -->|"activates"| Inflammation["Inflammation"]
    ENDOGENOUS_DNA -->|"activates"| Autoimmune["Autoimmune"]
    ENDOGENOUS_DNA -->|"inhibits"| Tumor["Tumor"]
    STING["STING"] -->|"activates"| ENDOGENOUS_DNA
    CGAS["CGAS"] -->|"activates"| ENDOGENOUS_DNA
    GENES -->|"activates"| ENDOGENOUS_DNA
    PATHOGENIC_DNA["PATHOGENIC DNA"] -->|"activates"| ENDOGENOUS_DNA
    DNA -->|"activates"| ENDOGENOUS_DNA
    ROS["ROS"] -->|"causes"| ENDOGENOUS_DNA
    NEURODEGENERATION["NEURODEGENERATION"] -->|"causes"| ENDOGENOUS_DNA
    APOPTOSIS["APOPTOSIS"] -->|"causes"| ENDOGENOUS_DNA

Outgoing (59)

Target	Relation	Type	Str
GENES	activates	gene	0.70
DNA	activates	gene	0.70
Senescence	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	causes	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Infection	activates	disease	0.65
EXTRANUCLEAR CHROMATIN	activates	gene	0.60
Autophagy	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mapk	activates	pathway	0.60
Immune Response	activates	pathway	0.60
MYC	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
CDK12	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
DNA	associated_with	gene	0.60
Oxidative Stress	associated_with	pathway	0.60
DNA	causes	gene	0.60
Apoptosis	causes	pathway	0.60
Dna Repair	causes	pathway	0.60
JAK2	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
MTDNA	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
DNA	inhibits	gene	0.60
TLR9	inhibits	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Toll-Like Receptor	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Mitochondrial Function	inhibits	pathway	0.60
NF-ΚB	activates	gene	0.60
PATHOGENIC DNA	activates	gene	0.60
CGAS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
STING	activates	gene	0.60

Incoming (24)

Source	Relation	Type	Str
STING	activates	gene	0.60
CGAS	activates	gene	0.60
GENES	activates	gene	0.60
PATHOGENIC DNA	activates	gene	0.60
DNA	activates	gene	0.60
GENES	expressed_in	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
ROS	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
APOPTOSIS	causes	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GASTRODIN	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
EXTRANUCLEAR CHROMATIN	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AND	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MAPK	activates	gene	0.60
NF-ΚB	activates	gene	0.60
CGAS-STING	activates	gene	0.60
AND	regulates	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ENDOGENOUS DNA

Understanding Entity Pages

Wiki Pages (17)

cbs-psp-daily-action-plan

Parthanatos in Neurodegeneration

DNA Damage Response in Parkinson's Disease

DNA Damage Response in Corticobasal Syndrome

DNA Sensing Pathways in Neurodegeneration

PRIMPOL — DNA Primase/Polymerase

Neuroinflammation in Neurodegeneration

FANCF Gene

FANCA Gene

DNA Damage Repair Therapy for Neurodegeneration

AIM2 Protein — Absent in Melanoma 2

DNA Damage Response in Neurodegeneration

MBD4 Protein - Methyl-CpG Binding Domain Protein 4

LIG4

DNA Ligase III Protein