disease

Myocardial Infarction

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Myocardial Infarction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

456Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	INSULIN RESISTANCE, OXIDATIVE STRESS, INFLAMMATION, MITOCHONDRIAL DYSFUNCTION, MITOCHONDRIA, MITOPHAGY, FUNDC1, CD36
Therapeutic Agents	TMZ
KG Connections	446 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Myocardial_Infarction["<b>Myocardial Infarction</b>"]
    Cardiac{"Cardiac"}
    Myocardial_Infarction -->|"activates"| Cardiac
    Sympathetic_Remodeling["Sympathetic Remodeling"]
    Myocardial_Infarction -->|"causes"| Sympathetic_Remodeling
    Apoptosis["Apoptosis"]
    Myocardial_Infarction -->|"therapeutic_target"| Apoptosis
    Inflammation{"Inflammation"}
    Myocardial_Infarction -->|"activates"| Inflammation
    Atherosclerosis{"Atherosclerosis"}
    Myocardial_Infarction -->|"associated_with"| Atherosclerosis
    Als{"Als"}
    Als -->|"activates"| Myocardial_Infarction
    Cardiovascular{"Cardiovascular"}
    Cardiovascular -->|"therapeutic_target"| Myocardial_Infarction
    style Myocardial_Infarction fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (143)

Target	Relation	Type	Str
Cardiac	activates	disease	1.00
Cardiac	therapeutic_target	disease	1.00
Sympathetic Remodeling	causes	process	0.95
Chronic Heart Failure	causes	disease	0.95
Apoptosis	therapeutic_target	pathway	0.90
Inflammation	activates	disease	0.85
Atherosclerosis	associated_with	disease	0.85
Apoptosis	activates	pathway	0.80
Cardiac	implicated_in	disease	0.75
Cardiac	regulates	disease	0.75
Heart Failure	associated_with	disease	0.75
Coronary Artery Disease	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Cardiac	biomarker_for	disease	0.75
Cholesterol	causes	pathway	0.70
Mitophagy	implicated_in	pathway	0.70
Lipid Metabolism	implicated_in	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Glycolysis	activates	pathway	0.70
Er Stress	therapeutic_target	pathway	0.70
Senescence	associated_with	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Microrna	therapeutic_target	pathway	0.70
Arrhythmia	activates	disease	0.65
Cardiac	inhibits	disease	0.65
Stroke	activates	disease	0.65
Inflammation	causes	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Stroke	associated_with	disease	0.65
Stroke	causes	disease	0.65
Heart Failure	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Stroke	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Pi3K/Akt	activates	pathway	0.60
Ampk Signaling	activates	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Autophagy	implicated_in	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Wnt	regulates	pathway	0.60
Oxidative Stress	inhibits	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Ferroptosis	expressed_in	pathway	0.60
Angiogenesis	activates	pathway	0.60
Mitochondrial Function	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60

Incoming (313)

Source	Relation	Type	Str
Als	activates	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cardiovascular	activates	disease	1.00
Cardiovascular	associated_with	disease	1.00
INFLAMMATION	activates	gene	0.95
APOPTOSIS	therapeutic_target	gene	0.95
STROKE	causes	gene	0.95
miR-199a-5p	downregulates	biomarker	0.95
High-Sensitivity C-Reactive Protein	risk_factor_for	biomarker	0.92
ferroptosis	contributes_to	process	0.90
Microglia Activation	associated_with	process	0.85
Cellular Senescence	involved_in	process	0.85
Microglia	involved_in	cell_type	0.85
DIABETES MELLITUS	activates	gene	0.85
APOPTOSIS	activates	gene	0.85
Ischemia	activates	disease	0.85
Ischemia	therapeutic_target	disease	0.85
STROKE	associated_with	gene	0.85
LDL	associated_with	gene	0.85
LOC100911717	upregulates	gene	0.85
LOC100911717	involved_in	gene	0.85
Macrophage	involved_in	cell_type	0.85
High-Sensitivity C-Reactive Protein	biomarker_for	biomarker	0.85
Low-Density Lipoprotein Cholesterol	biomarker_for	biomarker	0.85
Lipoprotein(A)	biomarker_for	biomarker	0.85
Colonoscopy	causes	process	0.85
TMZ	treats	drug	0.85
CHIP	risk_factor_for	process	0.85
Microglia	regulates	cell_type	0.80
LOC100911717	biomarker_for	gene	0.75
AMPK	activates	gene	0.75
EXOSOMES	activates	gene	0.75
Ischemia	causes	disease	0.75
INFLAMMATION	causes	gene	0.75
STROKE	activates	gene	0.75
Diabetes	activates	disease	0.75
GENES	activates	gene	0.75
MITOPHAGY	implicated_in	gene	0.75
MITOCHONDRIA	therapeutic_target	gene	0.75
OXIDATIVE STRESS	regulates	gene	0.75
CANCER	implicated_in	gene	0.75
ROS	activates	gene	0.75
STROKE	contributes_to	gene	0.75
Cardiovascular	regulates	disease	0.75
ATP	activates	gene	0.75
INFLAMMATION	associated_with	gene	0.75
INFLAMMATION	therapeutic_target	gene	0.75
INFLAMMATION	regulates	gene	0.75
STROKE	inhibits	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Myocardial Infarction

Understanding Entity Pages

Wiki Pages (20)

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

ND0612 Subcutaneous Levodopa Infusion PD Trial (NCT04006210)

Fabry Disease Pathway

PON2 (Paraoxonase 2)

Dopamine Agonists

MTHFR (Methylenetetrahydrofolate Reductase)

Physical Exercise Therapy for Parkinson's Disease

IL1RL1 Gene

staree-statin-dementia-prevention

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 1 (NCT06976216)

CXCR4 Gene

Seckel Syndrome

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

Ozanimod for Alzheimer's Disease (NCT06862960)

PRKCE Gene

Varenicline for Falls in Hypocholinergic Parkinson Disease (NCT06679374)

Recombinant Human Serum Albumin for Alzheimer's Disease (NCT06489015)

HSPB5 Protein — Alpha B-Crystallin