gene

SESN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

555Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SESN2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 257 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSESN2
Full NameSestrin 2
Chromosome1p35.3
Protein FamilySestrin family (SESN1-3)
Functionis a stress-inducible protein that functions as a critical regulator of cellular homeostasis, metabolic adaptation, and stress resistance [1].
Molecular Weight57 kDa
Amino Acids504 aa
Pathwayssignaling: ```mermaid, mTOR, mtor, AMPK, AMPK signaling
UniProt IDQ9Y7X7
NCBI Gene ID83667
Ensembl IDENSG00000140299
OMIM607336
GeneCardsSESN2
Human Protein AtlasSESN2
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer's disease
InteractionsRB1, BCL2L13, SNCAIP, ERN1, P62, PINK1
KG Connections555 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SESN2 — AlphaFold Q9Y7X7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

SESN2 Gene

gene · 1337 words

GBA Gene Mutations and Parkinson's Disease Risk

mechanism · 3113 words

TUFM Gene

gene · 2437 words

Sestrin Signaling Pathway in Neurodegeneration

mechanism · 1194 words

SESN2 Protein

protein · 1133 words

SESN1 Protein

protein · 929 words

Pathway Diagram

graph TD
    SESN2["SESN2"] -->|"Associated With"| Alzheimer_s_disease["Alzheimer's disease"]
    SESN2["SESN2"] -->|"Interacts With"| Dementia["Dementia"]
    SESN2["SESN2"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    SESN2["SESN2"] -->|"Interacts With"| Als["Als"]
    SESN2["SESN2"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    SESN2["SESN2"] -->|"Interacts With"| Parkinson["Parkinson"]
    SESN2["SESN2"] -->|"Interacts With"| Ms["Ms"]
    SESN2["SESN2"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CAT["CAT"] -->|"Interacts With"| SESN2["SESN2"]
    OPTN["OPTN"] -->|"Interacts With"| SESN2["SESN2"]
    DNM1L["DNM1L"] -->|"Interacts With"| SESN2["SESN2"]
    CANX["CANX"] -->|"Interacts With"| SESN2["SESN2"]
    LGALS3["LGALS3"] -->|"Interacts With"| SESN2["SESN2"]
    style SESN2 fill:#8d4900,color:#e0e0e0
    style Alzheimer_s_disease fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (245)

TargetRelationTypeStr
KEAP1regulatesgene0.95
NFE2L2regulatesgene0.95
PRKAA1regulatesgene0.95
Alzheimer's diseaseassociated_withdisease0.70
Dementiainteracts_withdisease0.65

Incoming (310)

SourceRelationTypeStr
Rhoifolinupregulatescompound0.90
CATinteracts_withgene0.60
OPTNinteracts_withgene0.60
DNM1Linteracts_withgene0.60
CANXinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found