Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SESN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SESN2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 257 entities in the SciDEX knowledge graph.
| Gene Symbol | SESN2 |
| Full Name | Sestrin 2 |
| Chromosome | 1p35.3 |
| Protein Family | Sestrin family (SESN1-3) |
| Function | is a stress-inducible protein that functions as a critical regulator of cellular homeostasis, metabolic adaptation, and stress resistance [1]. |
| Molecular Weight | 57 kDa |
| Amino Acids | 504 aa |
| Pathways | signaling: ```mermaid, mTOR, mtor, AMPK, AMPK signaling |
| UniProt ID | Q9Y7X7 |
| NCBI Gene ID | 83667 |
| Ensembl ID | ENSG00000140299 |
| OMIM | 607336 |
| GeneCards | SESN2 |
| Human Protein Atlas | SESN2 |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Alzheimer's disease |
| Interactions | RB1, BCL2L13, SNCAIP, ERN1, P62, PINK1 |
| KG Connections | 555 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SESN2["SESN2"] -->|"Associated With"| Alzheimer_s_disease["Alzheimer's disease"]
SESN2["SESN2"] -->|"Interacts With"| Dementia["Dementia"]
SESN2["SESN2"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
SESN2["SESN2"] -->|"Interacts With"| Als["Als"]
SESN2["SESN2"] -->|"Interacts With"| Alzheimer["Alzheimer"]
SESN2["SESN2"] -->|"Interacts With"| Parkinson["Parkinson"]
SESN2["SESN2"] -->|"Interacts With"| Ms["Ms"]
SESN2["SESN2"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
CAT["CAT"] -->|"Interacts With"| SESN2["SESN2"]
OPTN["OPTN"] -->|"Interacts With"| SESN2["SESN2"]
DNM1L["DNM1L"] -->|"Interacts With"| SESN2["SESN2"]
CANX["CANX"] -->|"Interacts With"| SESN2["SESN2"]
LGALS3["LGALS3"] -->|"Interacts With"| SESN2["SESN2"]
style SESN2 fill:#8d4900,color:#e0e0e0
style Alzheimer_s_disease fill:#b71c1c,color:#e0e0e0
style Dementia fill:#b71c1c,color:#e0e0e0
style Cardiovascular fill:#b71c1c,color:#e0e0e0
style Als fill:#b71c1c,color:#e0e0e0
style Alzheimer fill:#b71c1c,color:#e0e0e0
style Parkinson fill:#b71c1c,color:#e0e0e0
style Ms fill:#b71c1c,color:#e0e0e0
style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
style CAT fill:#8d4900,color:#e0e0e0
style OPTN fill:#8d4900,color:#e0e0e0
style DNM1L fill:#8d4900,color:#e0e0e0
style CANX fill:#8d4900,color:#e0e0e0
style LGALS3 fill:#8d4900,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| KEAP1 | regulates | gene | 0.95 |
| NFE2L2 | regulates | gene | 0.95 |
| PRKAA1 | regulates | gene | 0.95 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Cardiac | activates | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| RB1 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rhoifolin | upregulates | compound | 0.90 |
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||