gene

MT1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MT1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

39Outgoing

18Incoming

Summary

Metallothionein-1A metal homeostasis and neuroprotection

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🧬 Gene Info

Gene Symbol	MT1A
Full Name	Metallothionein-1A
Chromosome	16q13
Molecular Weight	7 kDa
Amino Acids	61 aa
Pathways	MAPK signaling, lipid metabolism, oxidative stress response
UniProt ID	P07148
NCBI Gene ID	4489
Ensembl ID	ENSG00000125148
OMIM	156360
GeneCards	MT1A
Human Protein Atlas	MT1A
Encoded Protein	Metallothionein-1A
Protein Size	61 amino acids (~6-7 kDa)
Region	Expression Level
Associated Diseases	neuroinflammation, oxidative stress
Interactions	CD44, MAPK1, CLU, TNF, MMP1, GFAP
KG Connections	57 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MT1A — AlphaFold P07148 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MT1A["<b>MT1A</b>"]
    Alzheimer["Alzheimer"]
    MT1A -->|"interacts with"| Alzheimer
    Neuroinflammation["Neuroinflammation"]
    MT1A -->|"interacts with"| Neuroinflammation
    Inflammation["Inflammation"]
    MT1A -->|"interacts with"| Inflammation
    CD44["CD44"]
    MT1A -->|"interacts with"| CD44
    SOD1["SOD1"]
    MT1A -->|"associated with"| SOD1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MT1A -->|"interacts with"| OXIDATIVE_STRESS
    MAPK1["MAPK1"]
    MT1A -->|"interacts with"| MAPK1
    CLU["CLU"]
    MT1A -->|"interacts with"| CLU
    TNF["TNF"]
    MT1A -->|"interacts with"| TNF
    NFE2L2["NFE2L2"]
    MT1A -->|"associated with"| NFE2L2
    AND["AND"]
    MT1A -->|"associated with"| AND
    MMP1["MMP1"]
    MT1A -->|"interacts with"| MMP1
    ASTROCYTES["ASTROCYTES"]
    MT1A -->|"interacts with"| ASTROCYTES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MT1A -->|"interacts with"| ALZHEIMER_S_DISEASE
    HSPB1["HSPB1"]
    MT1A -->|"interacts with"| HSPB1
    ASTROCYTE["ASTROCYTE"]
    MT1A -->|"interacts with"| ASTROCYTE
    ALZHEIMER["ALZHEIMER"]
    MT1A -->|"interacts with"| ALZHEIMER
    GFAP["GFAP"]
    MT1A -->|"interacts with"| GFAP
    CRYAB["CRYAB"]
    MT1A -->|"interacts with"| CRYAB
    LRP1["LRP1"]
    MT1A -->|"interacts with"| LRP1
    CATHEPSINS["CATHEPSINS"]
    MT1A -->|"interacts with"| CATHEPSINS
    Oxidative_Stress["Oxidative Stress"]
    MT1A -->|"interacts with"| Oxidative_Stress
    Mapk["Mapk"]
    MT1A -->|"interacts with"| Mapk
    Sod1["Sod1"]
    MT1A -->|"associated with"| Sod1
    Lipid_Metabolism["Lipid Metabolism"]
    MT1A -->|"associated with"| Lipid_Metabolism
    NOS1["NOS1"]
    NOS1 -->|"associated with"| MT1A
    IL6["IL6"]
    IL6 -->|"interacts with"| MT1A
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"interacts with"| MT1A
    APOE["APOE"]
    APOE -->|"interacts with"| MT1A
    SERPINA3["SERPINA3"]
    SERPINA3 -->|"interacts with"| MT1A

Outgoing (39)

Target	Relation	Type	Str
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
CD44	interacts_with	gene	0.60
SOD1	associated_with	gene	0.60
MAPK1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NFE2L2	associated_with	gene	0.60
MMP1	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
CRYAB	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
CATHEPSINS	interacts_with	gene	0.60
NOS1	associated_with	gene	0.60
PRDX6	associated_with	gene	0.60
TNF	associated_with	gene	0.60
neuroinflammation	associated_with	disease	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
AND	associated_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
HSPB1	interacts_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
Oxidative Stress	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Sod1	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
Astrocyte	expressed_in	cell_type	0.55
CRYAB	associated_with	gene	0.50
SERPINA3	associated_with	gene	0.50
oxidative stress	associated_with	phenotype	0.50
LIPID METABOLISM	associated_with	pathway	0.50
Proteostasis	associated_with	process	0.50
EXTRACELLULAR MATRIX	associated_with	concept	0.50

Incoming (18)

Source	Relation	Type	Str
NOS1	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
SERPINA3	interacts_with	gene	0.60
PRDX6	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CRYAB	associated_with	gene	0.60
IL6	associated_with	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
APOE	associated_with	gene	0.50
LRP1	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
CD44	associated_with	gene	0.50
MAPK1	associated_with	gene	0.50
MMP1	associated_with	gene	0.50
Neuroinflammation	associated_with	process	0.50
Sod1	associated_with	gene	0.50
HSPB1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found