Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYOD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MYOD |
| Related Diseases | Ms, Als, Sarcopenia, Aging, Tumor |
| Related Pathways | Differentiation |
Knowledge base pages for this entity
graph TD
MYOD["MYOD"]
MYOD -->|"regulates"| Differentiation["Differentiation"]
MYOD -->|"interacts"| Ms["Ms"]
MYOD -->|"inhibits"| Als["Als"]
MYOD -->|"treats"| Sarcopenia["Sarcopenia"]
MYOD -->|"treats"| Aging["Aging"]
MYOD -->|"implicated in"| Tumor["Tumor"]
MYOD -->|"implicated in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
dCas9_Tet1["dCas9-Tet1"] -->|"activates"| MYOD
PIEZO1["PIEZO1"] -->|"interacts"| MYOD| Target | Relation | Type | Str |
|---|---|---|---|
| Differentiation | regulates | pathway | 0.70 |
| Ms | interacts_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Sarcopenia | treats | disease | 0.65 |
| Aging | treats | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Tumor | implicated_in | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | implicated_in | disease | 0.65 |
| Atherosclerosis | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| IGF1R | inhibits | gene | 0.60 |
| AKT | inhibits | gene | 0.60 |
| ERK1 | inhibits | gene | 0.60 |
| CHOP | inhibits | gene | 0.60 |
| HSPA5 | inhibits | gene | 0.60 |
| Akt | inhibits | pathway | 0.60 |
| ROS | treats | gene | 0.60 |
| OXIDATIVE STRESS | treats | gene | 0.60 |
| PI3K | treats | gene | 0.60 |
| P53 | regulates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | treats | gene | 0.60 |
| PSP | regulates | gene | 0.60 |
| GAL | treats | gene | 0.60 |
| P16 | regulates | gene | 0.60 |
| AKT | treats | gene | 0.60 |
| AGING | treats | gene | 0.60 |
| P21 | regulates | gene | 0.60 |
| MTOR | treats | gene | 0.60 |
| Pi3K/Akt | treats | pathway | 0.60 |
| Mtor | treats | pathway | 0.60 |
| Oxidative Stress | treats | pathway | 0.60 |
| Mitochondrial Function | treats | pathway | 0.60 |
| APOPTOSIS | implicated_in | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | implicated_in | gene | 0.60 |
| ALS | implicated_in | gene | 0.60 |
| OPTN | inhibits | gene | 0.60 |
| NEURON | implicated_in | gene | 0.60 |
| Apoptosis | implicated_in | pathway | 0.60 |
| Differentiation | inhibits | pathway | 0.60 |
| AKT | regulates | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| EGF | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Polygonatum sibiricum polysaccharide | upregulates | compound | 0.85 |
| Polygonatum Sibiricum Polysaccharide | upregulates | compound | 0.80 |
| PIEZO1 | interacts_with | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| P21 | regulates | gene | 0.60 |
| P53 | regulates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| P16 | regulates | gene | 0.60 |
| PSP | regulates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| GAL | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| MURF1 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||