concept

OLIG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	OLIG2 Gene
Summary	Page for OLIG2 Gene
Key Genes/Proteins	MOG, GBM, PARP1
Related Diseases	glioblastoma

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OLIG2["OLIG2"]
    OLIG2 -->|"regulates"| Astrocyte["Astrocyte"]
    OLIG2 -->|"inhibits"| Als["Als"]
    OLIG2 -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    OLIG2 -->|"inhibits"| Alzheimer["Alzheimer"]
    OLIG2 -->|"inhibits"| Inflammation["Inflammation"]
    OLIG2 -->|"inhibits"| Ms["Ms"]
    OLIG2 -->|"inhibits"| Notch["Notch"]
    OLIG2 -->|"inhibits"| Tgf__["Tgf-Beta"]
    HES1["HES1"] -->|"inhibits"| OLIG2
    ASTROCYTES["ASTROCYTES"] -->|"inhibits"| OLIG2
    NOTCH["NOTCH"] -->|"inhibits"| OLIG2
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"inhibits"| OLIG2
    TNF__["TNF-Alpha"] -->|"inhibits"| OLIG2
    CXCL2["CXCL2"] -->|"inhibits"| OLIG2
    PI3K["PI3K"] -->|"inhibits"| OLIG2
    MBP["MBP"] -->|"inhibits"| OLIG2

Outgoing (62)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Astrocyte	regulates	cell_type	0.80
stem cells	expressed_in	cell_type	0.80
MOG	causes	gene	0.70
astrocytes	expressed_in	cell_type	0.70
glioblastoma	regulates	disease	0.70
PARP1	co_discussed	gene	0.65
oligodendrocyte	co_discussed	concept	0.65
myelin	co_discussed	concept	0.65
astrocyte	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
OLIGODENDROCYTE	associated_with	concept	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
apoptosis	co_discussed	concept	0.65
OLIGODENDROCYTES	produces	cell_type	0.65
TNF	inhibits	gene	0.60
MOG	targets	gene	0.60
PARP1	co_expressed_with	gene	0.60
STING	co_expressed_with	gene	0.60
STAT1	activates	gene	0.60
SHH	causes	gene	0.60
SHH	inhibits	gene	0.60
TCF7L2	inhibits	gene	0.60
schizophrenia	inhibits	disease	0.60
TCF7L2	regulates	gene	0.60
glutamate signaling	participates_in	pathway	0.60
SOX10	causes	gene	0.60
TCF4	causes	gene	0.60
Notch	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
AND	activates	gene	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
MYELIN	inhibits	gene	0.60
CREB	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
Pi3K	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Synaptic Plasticity	inhibits	pathway	0.60
OLIGODENDROCYTE	implicated_in	cell_type	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
glioblastoma	activates	disease	0.60
apoptosis pathway	participates_in	pathway	0.60

Incoming (50)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Transcranial near-infrared light	upregulates	compound	0.85
GBM	regulates	gene	0.70
OLIGODENDROCYTE	stabilizes	cell_type	0.70
MBP	co_discussed	gene	0.65
MTOR	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
GFAP	co_discussed	gene	0.65
LRRK2	co_discussed	gene	0.65
SUBVENTRICULAR ZONE	causes	brain_region	0.65
NESTIN	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
HES1	inhibits	gene	0.60
CXCL2	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
MBP	inhibits	gene	0.60
AKT1	co_expressed_with	gene	0.60
MBP	co_expressed_with	gene	0.60
AKT1	activates	gene	0.60
ASCL1	regulates	gene	0.60
ASCL1	activates	gene	0.60
GBM	activates	gene	0.60
ASCL1	interacts_with	gene	0.60
GEM	inhibits	gene	0.60
GBM	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
AND	associated_with	gene	0.60
NOTCH	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
EXERCISE	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
OLIGODENDROCYTES	stabilizes	cell_type	0.60
DNA	interacts_with	gene	0.60
MEK	inhibits	gene	0.60
MBP	expressed_in	gene	0.55
MOG	expressed_in	gene	0.55
MBP	activates	gene	0.55
MOG	activates	gene	0.55
MBP	interacts_with	gene	0.55
MOG	interacts_with	gene	0.55
DNA	activates	gene	0.55
WHITE MATTER	associated_with	brain_region	0.50
PARP1	associated_with	gene	0.45
SUBVENTRICULAR ZONE	associated_with	brain_region	0.45
METFORMIN	associated_with	drug	0.45
CORPUS CALLOSUM	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OLIG2

Understanding Entity Pages

Wiki Pages (21)

OLIG2 Gene

Oligodendrocytes

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Remyelination in Neurodegeneration

FA2H Gene

GLI1 — GLI Family Zinc Finger 1

Demyelination

Oligodendrocyte Precursor Differentiation Failure in Neurodegeneration

Oligodendrocyte-Myelin Dysfunction Hypothesis in Parkinson's Disease

PSAP-GPR37-IL-6 Axis in Parkinson's Disease

Cell Type Atlas

OPALIN — Oligodendrocyte Myelin Membrane Protein

GLI Gene Family

Disease-Associated Oligodendrocytes

Oligodendroglial Involvement in Progressive Supranuclear Palsy

demyelination-remyelination-therapy-neurodegeneration

Spinal Ventral Horn Motor Neurons

Section 144: Advanced Myelin Repair and Oligodendrocyte Therapy in CBS/PSP

SHH — Sonic Hedgehog