concept

OLIG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OLIG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

1Hypotheses

2Analyses

50Outgoing

48Incoming

0Experiments

2Debates

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💡 Concept Info

Name	OLIG2
Key Genes/Proteins	AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE, APOPTOSIS
Related Diseases	Als, Alzheimer
Related Pathways	Apoptosis, apoptosis pathway

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OLIG2 Gene

gene · 682 words

→

Pathway Diagram

graph TD
    OLIG2["OLIG2"]
    OLIG2 -->|"regulates"| Astrocyte["Astrocyte"]
    OLIG2 -->|"inhibits"| Als["Als"]
    OLIG2 -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    OLIG2 -->|"inhibits"| Alzheimer["Alzheimer"]
    OLIG2 -->|"inhibits"| Inflammation["Inflammation"]
    OLIG2 -->|"inhibits"| Ms["Ms"]
    OLIG2 -->|"inhibits"| Notch["Notch"]
    OLIG2 -->|"inhibits"| Tgf__["Tgf-Beta"]
    HES1["HES1"] -->|"inhibits"| OLIG2
    ASTROCYTES["ASTROCYTES"] -->|"inhibits"| OLIG2
    NOTCH["NOTCH"] -->|"inhibits"| OLIG2
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"inhibits"| OLIG2
    TNF__["TNF-Alpha"] -->|"inhibits"| OLIG2
    CXCL2["CXCL2"] -->|"inhibits"| OLIG2
    PI3K["PI3K"] -->|"inhibits"| OLIG2
    MBP["MBP"] -->|"inhibits"| OLIG2

Outgoing (63)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
Astrocyte	regulates	cell_type	0.80
stem cells	expressed_in	cell_type	0.80
oligodendrocyte differentiation	regulates	process	0.70
glioblastoma	regulates	disease	0.70
MOG	causes	gene	0.70
Oligodendrocyte Function	regulates	phenotype	0.70
astrocytes	expressed_in	cell_type	0.70
PARP1	co_discussed	gene	0.65
Als	inhibits	disease	0.65
OLIGODENDROCYTE	associated_with	cell_type	0.65
astrocyte	co_discussed	concept	0.65
apoptosis	co_discussed	process	0.65
Neuroinflammation	inhibits	disease	0.65
oligodendrocyte	co_discussed	concept	0.65
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
OLIGODENDROCYTES	produces	cell_type	0.65
Alzheimer	inhibits	disease	0.65
myelin	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
Synaptic Plasticity	inhibits	pathway	0.60
AND	activates	gene	0.60
MOG	targets	gene	0.60
NEURON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
MYELIN	inhibits	gene	0.60
CREB	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
Pi3K	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
TNF	inhibits	gene	0.60
SHH	inhibits	gene	0.60
TCF7L2	inhibits	gene	0.60
schizophrenia	inhibits	disease	0.60
TCF7L2	regulates	gene	0.60
glutamate signaling	participates_in	pathway	0.60
SOX10	causes	gene	0.60
TCF4	causes	gene	0.60
SHH	causes	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
Notch	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
glioblastoma	activates	disease	0.60
PARP1	co_expressed_with	gene	0.60
apoptosis pathway	participates_in	pathway	0.60

Incoming (48)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
Transcranial near-infrared light	upregulates	compound	0.85
OLIGODENDROCYTE	stabilizes	cell_type	0.70
GBM	regulates	gene	0.70
GFAP	co_discussed	gene	0.65
MTOR	co_discussed	gene	0.65
MBP	co_discussed	gene	0.65
SUBVENTRICULAR ZONE	causes	brain_region	0.65
LRRK2	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
OLIGODENDROCYTES	stabilizes	cell_type	0.60
MBP	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
MBP	inhibits	gene	0.60
NOTCH	inhibits	gene	0.60
CXCL2	inhibits	gene	0.60
DNA	interacts_with	gene	0.60
MEK	inhibits	gene	0.60
ASCL1	activates	gene	0.60
GBM	activates	gene	0.60
ASCL1	interacts_with	gene	0.60
GEM	inhibits	gene	0.60
GBM	inhibits	gene	0.60
ASCL1	regulates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
GFAP	associated_with	gene	0.60
HES1	inhibits	gene	0.60
AKT1	co_expressed_with	gene	0.60
AKT1	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
NESTIN	associated_with	gene	0.60
EXERCISE	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
DNA	activates	gene	0.55
MOG	activates	gene	0.55
MOG	expressed_in	gene	0.55
MBP	expressed_in	gene	0.55
MOG	interacts_with	gene	0.55
MBP	activates	gene	0.55
WHITE MATTER	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.45
PARP1	associated_with	gene	0.45
SUBVENTRICULAR ZONE	associated_with	brain_region	0.45
CORPUS CALLOSUM	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Myelin Interface Restoration Therapy	0.000	-	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data)

neurodegeneration | 2026-04-03 | 5 hypotheses Top: 0.606

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

closed · Rounds: 4 · Score: 0.92 · 2026-04-03

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.71 · 2026-04-02

Related Research

Hypotheses and analyses mentioning OLIG2 in their description or question text

No additional research found