concept

SORLA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORLA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

95Connections

0Hypotheses

1Analyses

50Outgoing

30Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SORLA
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP, ARRB2
Related Diseases	Als, ALS, Alzheimer, Alzheimer's disease, atherosclerosis
Related Pathways	Amyloid

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SORLA Gene

gene · 873 words

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Pathway Diagram

graph TD
    SORLA["SORLA"]
    SORLA -->|"implicated in"| Diabetes["Diabetes"]
    SORLA -->|"implicated in"| Bipolar["Bipolar"]
    SORLA -->|"implicated in"| Als["Als"]
    SORLA -->|"implicated in"| Coronary_Artery_Disease["Coronary Artery Disease"]
    SORLA -->|"implicated in"| Alzheimer["Alzheimer"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| SORLA
    AND["AND"] -->|"inhibits"| SORLA
    LYSOSOME["LYSOSOME"] -->|"activates"| SORLA
    MICROGLIA["MICROGLIA"] -->|"contributes to"| SORLA
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| SORLA
    AMYLOID["AMYLOID"] -->|"activates"| SORLA
    SORL1["SORL1"] -->|"inhibits"| SORLA

Outgoing (65)

Target	Relation	Type	Str
retromer-dependent mechanism	modulates	pathway	0.70
APP trafficking away from endosomes	regulates	mechanism	0.70
Diabetes	implicated_in	disease	0.65
Bipolar	implicated_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	causes	disease	0.65
Als	activates	disease	0.65
Coronary Artery Disease	implicated_in	disease	0.65
ALS	activates	disease	0.65
Obesity	contributes_to	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Amyloid	expressed_in	pathway	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
Microglia	inhibits	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Alzheimer's disease	causes	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
neurons	expressed_in	cell_type	0.60
synaptic plasticity	participates_in	pathway	0.60
SORCS1	associated_with	gene	0.60
PRESENILIN	expressed_in	gene	0.60
APP	implicated_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
Ngf	associated_with	protein	0.60
Raf	interacts_with	protein	0.60
Neurogenesis	transports	pathway	0.60
Neuron	transports	cell_type	0.60
APP	interacts_with	protein	0.60
VPS10	associated_with	protein_family	0.60
obesity	associated_with	disease	0.60
SORCS3	associated_with	gene	0.60
APP	inhibits	gene	0.60
SORCS2	associated_with	gene	0.60
NGF	associated_with	gene	0.60
TAU	associated_with	gene	0.60
neurodegeneration	activates	disease	0.60
SORL1	associated_with	gene	0.60
Aβ	associated_with	protein	0.60
Exocytosis	contributes_to	pathway	0.60
Immune Response	contributes_to	pathway	0.60
Lysosomal Degradation	inhibits	pathway	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PKC	activates	gene	0.60
Rb	expressed_in	protein	0.60

Incoming (30)

Source	Relation	Type	Str
NEURODEGENERATION	regulates	gene	0.60
MICROGLIA	inhibits	gene	0.60
AND	inhibits	gene	0.60
TNF	transports	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	causes	gene	0.60
AMYLOID	expressed_in	gene	0.60
PRESENILIN	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
SORL1	inhibits	gene	0.60
SORL1	encodes	gene	0.60
PKCι	regulates	protein	0.60
ARRB2	regulates	protein	0.60
SORL1	causes	gene	0.60
LDLR	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
LYSOSOME	activates	gene	0.60
MICROGLIA	contributes_to	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
SORL1	associated_with	gene	0.60
APP	inhibits	gene	0.60
PKC	activates	gene	0.60
SORCS1	associated_with	gene	0.60
SORCS2	associated_with	gene	0.60
NGF	associated_with	gene	0.60
TAU	associated_with	gene	0.60
SORCS3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can retromer-stabilizing compounds like R55 prevent neurodegeneration in vivo?

neurodegeneration | 2026-04-26 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can retromer-stabilizing compounds like R55 prevent neurodegeneration in vivo?

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning SORLA in their description or question text

No additional research found