concept

ST6GAL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ST6GAL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

143Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ST6GAL1 is a concept in neurodegeneration research. Key relationships include: regulates, associated with, co discussed. Associated with ALS, Als, Arthritis. Connected to 55 entities in the SciDEX knowledge graph.

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🔮 Predicted Structure: ST6GAL1 — AlphaFold C9J6X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    ST6GAL1["ST6GAL1"]
    ST6GAL1 -->|"inhibits"| hepatocellular_carcinoma["hepatocellular carcinoma"]
    ST6GAL1 -->|"inhibits"| liver_inflammation["liver inflammation"]
    ST6GAL1 -->|"interacts"| CD22["CD22"]
    ST6GAL1 -->|"regulates"| Als["Als"]
    ST6GAL1 -->|"regulates"| Cancer["Cancer"]
    ST6GAL1 -->|"regulates"| Ms["Ms"]
    ST6GAL1 -->|"activates"| Arthritis["Arthritis"]
    ST6GAL1 -->|"transports"| ALS["ALS"]
    IL_1_["IL-1beta"] -->|"contributes to"| ST6GAL1
    IL6["IL6"] -->|"contributes to"| ST6GAL1
    NF_kB["NF-kB"] -->|"regulates"| ST6GAL1
    STAT3["STAT3"] -->|"regulates"| ST6GAL1
    h_9a108e26["h-9a108e26"] -->|"targets"| ST6GAL1
    JUN["JUN"] -->|"regulates"| ST6GAL1
    FUT8["FUT8"] -->|"expressed in"| ST6GAL1
    APP["APP"] -->|"regulates"| ST6GAL1
    BACE1["BACE1"] -->|"regulates"| ST6GAL1

Outgoing (86)

Target	Relation	Type	Str
Igg Glycosylation	regulates	process	0.95
α2,6-sialylation	associated_with	process	0.95
IgG Sialylation	regulates	process	0.95
alpha2,6-sialylation	mediates	process	0.95
IgG	regulates	protein	0.90
hepatocellular carcinoma	inhibits	disease	0.90
CD22	interacts_with	receptor	0.80
liver inflammation	inhibits	biological_process	0.80
non-fucosylated N-glycans	associated_with	compound	0.80
liver	expressed_in	cell_type	0.80
GLUT2	regulates	protein	0.75
plasma cells	associated_with	cell_type	0.70
colorectal cancer	associated_with	disease	0.70
Various Human Diseases	associated_with	disease	0.70
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	transports	disease	0.65
Als	transports	disease	0.65
Arthritis	activates	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
CANCER	modifies	disease	0.60
TCR	regulates	gene	0.60
B Cell	transports	cell_type	0.60
MAX	regulates	gene	0.60
EGFR	regulates	gene	0.60
BACE1	regulates	gene	0.60
FUT8	regulates	gene	0.60
APP	regulates	gene	0.60
brain metastasis	associated_with	disease	0.60
STAT3	activates	gene	0.60
ERBB3	regulates	gene	0.60
AND	regulates	gene	0.60
Epithelial	regulates	cell_type	0.60
Tgf-Β	regulates	pathway	0.60
CANCER	activates	gene	0.60
IL-6	activates	gene	0.60
FUT8	expressed_in	gene	0.60
JUN	regulates	gene	0.60
FUT8	activates	gene	0.60
Rb	regulates	protein	0.60
Ras	expressed_in	protein	0.60

Incoming (57)

Source	Relation	Type	Str
STAT3	regulates	protein	0.90
IL6	contributes_to	protein	0.90
NF-kB	regulates	protein	0.90
h-9a108e26	targets_gene	hypothesis	0.90
B Cell	expressed_in	cell_type	0.90
IL-1β	contributes_to	protein	0.90
h-9a108e26	targets	hypothesis	0.80
FUT8	co_mentioned_with	gene	0.70
GBM	associated_with	gene	0.70
EGFR	associated_with	gene	0.60
JUN	regulates	gene	0.60
FUT8	expressed_in	gene	0.60
FUT8	activates	gene	0.60
FUT8	associated_with	gene	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
APP	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
FUT8	regulates	gene	0.60
JUN	transports	gene	0.60
ST3GAL2	expressed_in	gene	0.60
FUT6	interacts_with	gene	0.60
ERBB3	associated_with	gene	0.60
EGFR	regulates	gene	0.60
TCR	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	activates	gene	0.60
AND	expressed_in	gene	0.60
FUT8	upregulates	entity	0.60
GENES	associated_with	gene	0.60
ERBB3	regulates	gene	0.60
GENES	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ST3GAL2	methylates	gene	0.60
APOE4	activates	gene	0.55
FUT8	targets	gene	0.55
APOE4	expressed_in	gene	0.55
APOE4	interacts_with	gene	0.55
APOE4	regulates	gene	0.55
FUT8	binds_to	gene	0.55
C1Q	activates	gene	0.55
phagocytosis	activates	process	0.55
B Cell	associated_with	cell_type	0.50
B Cell	activates	cell_type	0.50
TRANSFERRIN	interacts_with	protein	0.50
TUMOR	expressed_in	disease	0.50
GALNT3	expressed_in	gene	0.50
cancer	expressed_in	disease	0.50
FUT8	interacts_with	gene	0.43
ST3GAL2	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06