disease

Type 1 Diabetes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Type 1 Diabetes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

46Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	STROKE, PER, DIABETES MELLITUS, MIRNAS
KG Connections	102 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Type_1_Diabetes["Type 1 Diabetes"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
    Type_1_Diabetes["Type 1 Diabetes"] -->|"therapeutic target"| Diabetes["Diabetes"]
    Type_1_Diabetes["Type 1 Diabetes"] -->|"therapeutic target"| Als["Als"]
    Type_1_Diabetes["Type 1 Diabetes"] -->|"implicated in"| Diabetes_1["Diabetes"]
    Type_1_Diabetes["Type 1 Diabetes"] -->|"regulates"| Diabetes_2["Diabetes"]
    Type_1_Diabetes["Type 1 Diabetes"] -->|"associated"| Diabetes_3["Diabetes"]
    IL_6["IL-6"] -->|"therapeutic target"| Type_1_Diabetes["Type 1 Diabetes"]
    TNF["TNF"] -->|"therapeutic target"| Type_1_Diabetes["Type 1 Diabetes"]
    TNF__["TNF-Alpha"] -->|"therapeutic target"| Type_1_Diabetes["Type 1 Diabetes"]
    ATG["ATG"] -->|"activates"| Type_1_Diabetes["Type 1 Diabetes"]
    style Type_1_Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Autoimmune	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Diabetes	implicated_in	disease	0.65
Diabetes	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Mitochondrial Function	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Immunotherapy	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Tgf-Β	therapeutic_target	pathway	0.60
Immune Response	treats	pathway	0.60
Microrna	biomarker_for	pathway	0.60
Epigenetic	implicated_in	pathway	0.60
Immune Response	implicated_in	pathway	0.60
Epigenetic	treats	pathway	0.60
Inflammation	therapeutic_target	disease	0.55
Diabetes	activates	disease	0.55
Inflammation	activates	disease	0.55
Diabetes	treats	disease	0.55
Diabetes	inhibits	disease	0.55
Inflammation	inhibits	disease	0.55
Lupus	therapeutic_target	disease	0.55
Psoriasis	therapeutic_target	disease	0.55
Cardiovascular	implicated_in	disease	0.55
Als	associated_with	disease	0.55
Myocardial Infarction	associated_with	disease	0.55
Coronary Artery Disease	associated_with	disease	0.55
Heart Failure	associated_with	disease	0.55
Stroke	associated_with	disease	0.55
Neuropathy	therapeutic_target	disease	0.55
Metabolic Syndrome	therapeutic_target	disease	0.55
Type 2 Diabetes	therapeutic_target	disease	0.55
Diabetes	causes	disease	0.55
Type 2 Diabetes	associated_with	disease	0.55
Infection	implicated_in	disease	0.55
Lupus	implicated_in	disease	0.55
Als	implicated_in	disease	0.55
Multiple Sclerosis	implicated_in	disease	0.55
Autoimmune	implicated_in	disease	0.55
Als	treats	disease	0.55
Viral Infection	treats	disease	0.55
Autoimmune	regulates	disease	0.55
CARDIOMYOCYTES	activates	concept	0.50

Incoming (57)

Source	Relation	Type	Str
IL-6	therapeutic_target	gene	0.85
TNF	therapeutic_target	gene	0.75
TNF-Α	therapeutic_target	gene	0.75
Niacin	protects_against	drug	0.70
ATG	activates	gene	0.65
FOXP3	therapeutic_target	gene	0.65
INFLAMMATION	therapeutic_target	gene	0.65
CD4	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
CYTOKINES	treats	gene	0.65
INFLAMMATION	activates	gene	0.65
MITOCHONDRIAL DNA	activates	gene	0.65
PROINFLAMMATORY CYTOKINES	treats	gene	0.65
MITOCHONDRIA	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.65
DNA	activates	gene	0.65
ATP	activates	gene	0.65
INFLAMMATION	inhibits	gene	0.65
CD4	therapeutic_target	gene	0.65
BAX	therapeutic_target	gene	0.65
APOPTOSIS	therapeutic_target	gene	0.65
TLR4	therapeutic_target	gene	0.65
STAT3	therapeutic_target	gene	0.65
CYTOKINES	therapeutic_target	gene	0.65
NF-ΚB	therapeutic_target	gene	0.65
FAS	therapeutic_target	gene	0.65
BCL-2	therapeutic_target	gene	0.65
STROKE	associated_with	gene	0.65
PER	associated_with	gene	0.65
DIABETES MELLITUS	associated_with	gene	0.65
OVERVIEW	treats	gene	0.65
GENES	treats	gene	0.65
MIRNAS	associated_with	gene	0.65
VIRAL INFECTIONS	treats	gene	0.65
Als	associated_with	disease	0.55
Tumor	treats	disease	0.55
Rheumatoid Arthritis	inhibits	disease	0.55
Rheumatoid Arthritis	therapeutic_target	disease	0.55
Als	implicated_in	disease	0.55
Autoimmune	associated_with	disease	0.55
Als	protects_against	disease	0.55
Autoimmune	therapeutic_target	disease	0.55
Obesity	associated_with	disease	0.55
Rheumatoid Arthritis	implicated_in	disease	0.55
Infection	treats	disease	0.55
DIABETES	associated_with	disease	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
Rheumatoid Arthritis	associated_with	disease	0.50
Lupus	associated_with	disease	0.50
cardiomyopathy	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Type 1 Diabetes

Understanding Entity Pages

Wiki Pages (20)

nlrc5-protein

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Autoimmune Encephalitis

intermittent-fasting-neurodegeneration

stiff-person-syndrome

treg-regulatory-t-cell-therapy-parkinsons

Mitochondrial DNA Mutations in Neurodegeneration

sglt2-inhibitors-neurodegeneration

Wolfram Syndrome

Interleukin-2 Phase 2 (NCT06096090) — Immunomodulation for AD

CXCR5 Gene

FOXP3 (Forkhead Box P3)

STAT4 Gene

C4B Gene

Section 125 — Advanced Ketogenic and Metabolic Therapy for CBS/PSP

HLA-A — Major Histocompatibility Complex Class I A