Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dopamine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | dopamine |
| Category | Monoaminergic Neurons |
| Location | Substantia nigra pars compacta, Ventral tegmental area |
| Cell Types | Dopaminergic neurons expressing DAT |
| Primary Neurotransmitter | Dopamine |
| Key Markers | SLC6A3 (DAT), TH (tyrosine hydroxylase), AADC (aromatic L-amino acid decarboxylase) |
| Gene | SLC6A3 (Solute carrier family 6 member 3) |
| Associated Diseases | Parkinson's Disease |
| Known Drugs/Compounds | diabetic retinal neurodegeneration, NRF2, lipopolysaccharide, Ginsenoside Rb1 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
dopamine["dopamine"] -->|"modulates"| reward_based_motivation["reward-based motivation"]
style reward_based_motivation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"released by"| neurons["neurons"]
style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"released by"| dopaminergic_neurons["dopaminergic neurons"]
style dopaminergic_neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"active in"| substantia_nigra["substantia nigra"]
style substantia_nigra fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"active in"| striatum["striatum"]
style striatum fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"active in"| cortex["cortex"]
style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopamine["dopamine"] -->|"released by"| microglia["microglia"]
style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
DAT["DAT"] -->|"transports"| dopamine["dopamine"]
style DAT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
DRD2["DRD2"] -->|"binds"| dopamine["dopamine"]
style DRD2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Parkinson_s_disease["Parkinson's disease"] -->|"disrupts"| dopamine["dopamine"]
style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"disrupts"| dopamine["dopamine"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"disrupts"| dopamine["dopamine"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style dopamine fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| reward-based motivation | modulates | process | 0.95 |
| endocrine functions | regulates | process | 0.90 |
| neuronal uptake | regulates | process | 0.70 |
| diabetic retinal neurodegeneration | treats | disease | 0.70 |
| NRF2 | activates | protein | 0.70 |
| GPX4 | regulates | protein | 0.70 |
| BDNF | regulates | protein | 0.70 |
| striatum | expressed_in | brain_region | 0.70 |
| mesolimbic circuit | expressed_in | brain_region | 0.60 |
| neuron | loss_affects | entity | 0.60 |
| SNCA | loss_affects | entity | 0.60 |
| Alzheimer | loss_affects | entity | 0.60 |
| Parkinson | loss_affects | entity | 0.60 |
| neurodegeneration | loss_affects | entity | 0.60 |
| substantia nigra | loss_affects | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| COMT | degrades | gene | 0.80 |
| levodopa | converts_to | drug | 0.70 |
| lipopolysaccharide | inhibits | drug | 0.70 |
| Ginsenoside Rb1 | activates | drug | 0.70 |
| ginsenoside Rb1 | regulates | drug | 0.70 |
| COMT | regulates | gene | 0.64 |
| AADC | involved_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio | 0.494 | neuroscience | Circuit-level neural dynamics in neurode |
| Correcting Gut Microbial Dopamine Imbalance to Support Syste | 0.412 | neurodegeneration | What are the mechanisms by which gut mic |
| BH4 Cofactor Restoration as Primary Driver of >500-Fold Dopa | 0.396 | neurodegeneration | What molecular mechanisms underlie Atrem |
| Bacterial Enzyme-Mediated Dopamine Precursor Synthesis | 0.364 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gene therapy for Parkinson's disease: current landscape, translational challenge [PMID:41837837] | Evola V, Parmar MS | Expert review of neurotherapeu | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128] | ["Bolsewig K", "Bellomo G", "Hok-A-Hin Y | Nature medicine | 2026 | 0 |
| Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409] | Benina N, Buitrago L, De Simone FI, Radw | Brain | 2026 | 0 |
| Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147] | ["Bolsewig K", "Willemse E", "S\u00e1nch | Nature communications | 2025 | 0 |
| Neurosurgical gene therapy for central nervous system diseases. [PMID:39191071] | Patel RV, Nanda P, Richardson RM | Neurotherapeutics : the journa | 2024 | 0 |
| Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958] | ["Montillot C", "Skutunova E", "Ayushma" | Neurobiology of disease | 2023 | 0 |
| Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274] | ["Motta C", "Assogna M", "Bonomi C", "Di | European journal of neurology | 2023 | 0 |
| Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC d [PMID:34763085] | Tai CH, Lee NC, Chien YH, Byrne BJ, Mura | Molecular therapy : the journa | 2022 | 0 |
| Gene therapy restores dopamine transporter expression and ameliorates pathology [PMID:34011628] | Ng J, Barral S, De La Fuente Barrigon C, | Science translational medicine | 2021 | 0 |
| Current Clinical Applications of In Vivo Gene Therapy with AAVs. [PMID:33309881] | Mendell JR, Al-Zaidy SA, Rodino-Klapac L | Molecular therapy : the journa | 2021 | 0 |
| Targeting autophagy using small-molecule compounds to improve potential therapy [PMID:34729301] | Zhang K, Zhu S, Li J, Jiang T, Feng L, P | Acta pharmaceutica Sinica. B | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Graphene bilayers with a twist. [PMID:33208935] | ["Andrei E", "MacDonald A"] | Nature materials | 2020 | 0 |
| Reconstruction of cell spatial organization from single-cell RNA sequencing data [PMID:32541867] | ["Ren X", "Zhong G", "Zhang Q", "Zhang L | Cell research | 2020 | 0 |
| Gene therapy for neurodegenerative disorders: advances, insights and prospects. [PMID:32963936] | Chen W, Hu Y, Ju D | Acta pharmaceutica Sinica. B | 2020 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| Ligand entry in human ileal bile acid-binding protein is mediated by histidine p [PMID:30886237] | ["Horv\u00e1th G", "Egyed O", "Tang C", | Scientific reports | 2019 | 0 |
| [Skin Changes in POEMS Syndrome]. [PMID:30988219] | ["Kuwabara S"] | Brain and nerve = Shinkei kenk | 2019 | 0 |