concept

NEUROFIBRILLARY TANGLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROFIBRILLARY TANGLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

0Analyses

41Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NEUROFIBRILLARY TANGLES
Key Genes/Proteins	TAU, AMYLOID, AMYLOID-BETA
Related Diseases	NEUROINFLAMMATION, COGNITIVE DECLINE, NEURODEGENERATION, SYNAPTIC PLASTICITY, DEMENTIA

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NEUROFIBRILLARY_TANGLES["NEUROFIBRILLARY TANGLES"]
    NEUROFIBRILLARY_TANGLES -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    NEUROFIBRILLARY_TANGLES -->|"interacts"| TAU["TAU"]
    NEUROFIBRILLARY_TANGLES -->|"interacts"| NEURON["NEURON"]
    NEUROFIBRILLARY_TANGLES -->|"expressed in"| Entorhinal_Cortex["Entorhinal Cortex"]
    NEUROFIBRILLARY_TANGLES -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    TAU -->|"component_of"| NEUROFIBRILLARY_TANGLES
    HYPERPHOSPHORYLATED_TAU["HYPERPHOSPHORYLATED TAU"] -->|"causes"| NEUROFIBRILLARY_TANGLES
    AGGREGATED_TAU["AGGREGATED TAU"] -->|"component_of"| NEUROFIBRILLARY_TANGLES
    AMYLOID["AMYLOID"] -->|"interacts"| NEUROFIBRILLARY_TANGLES
    Phosphorylated_Tau["Phosphorylated Tau"] -->|"causes"| NEUROFIBRILLARY_TANGLES
    Tau_Phosphorylation["Tau Phosphorylation"] -->|"contributes to"| NEUROFIBRILLARY_TANGLES
    Alzheimer_s_Disease -->|"causes"| NEUROFIBRILLARY_TANGLES

Outgoing (55)

Target	Relation	Type	Str
TAU	interacts_with	protein	0.95
NEURON	interacts_with	cell_type	0.95
TAU	contributes_to	protein	0.80
AMYLOID-BETA	exacerbates	protein	0.70
NEUROINFLAMMATION	associated_with	process	0.65
TAU	activates	protein	0.65
NEUROINFLAMMATION	stabilizes	phenotype	0.65
COGNITIVE DECLINE	interacts_with	phenotype	0.65
NEURODEGENERATION	regulates	disease	0.65
SYNAPTIC PLASTICITY	causes	phenotype	0.65
NEURONS	causes	cell_type	0.65
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
NEURON	expressed_in	cell_type	0.50
TAU	phosphorylates	protein	0.50
ENTORHINAL CORTEX	associated_with	concept	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
CEREBRAL CORTEX	associated_with	brain_region	0.50
COMPLEMENT CASCADE	associated_with	pathway	0.50
MTOR PATHWAY	associated_with	pathway	0.50
NLRP3 INFLAMMASOME	associated_with	pathway	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
BDNF/TRKB SIGNALING	associated_with	pathway	0.45
BRAINSTEM	associated_with	brain_region	0.45
RAPAMYCIN	associated_with	drug	0.45
LITHIUM	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45
TEMPORAL LOBE	associated_with	brain_region	0.45
HYPOTHALAMUS	associated_with	brain_region	0.45
THALAMUS	associated_with	brain_region	0.45
TDP-43	expressed_in	gene	0.35
TAU	biomarker_for	protein	0.35
NEURON	phosphorylates	cell_type	0.35
TAU	processes	protein	0.35
ROS	activates	protein	0.35
NEURON	regulates	cell_type	0.35
NEURON	causes	cell_type	0.35
PROTEIN AGGREGATION	contributes_to	process	0.35
NEUROINFLAMMATION	contributes_to	process	0.35
NEURON	activates	cell_type	0.35
TAU	expressed_in	protein	0.35
NEUROINFLAMMATION	causes	process	0.35

Incoming (133)

Source	Relation	Type	Str
AMYLOID	interacts_with	protein	0.95
AMYLOID	contributes_to	protein	0.80
DEMENTIA	associated_with	disease	0.65
AMYLOID	activates	protein	0.65
ROS	regulates	phenotype	0.65
ROS	produces	phenotype	0.65
TAU	activates	protein	0.65
TAU	inhibits	protein	0.65
CDK5	causes	gene	0.65
INFLAMMATION	phosphorylates	phenotype	0.65
INFLAMMATION	causes	phenotype	0.65
GFAP	interacts_with	gene	0.65
TAU	produces	protein	0.60
TAU	participates_in	protein	0.55
AMYLOID	causes	protein	0.50
AMYLOID-BETA	interacts_with	protein	0.50
Tdp-43	expressed_in	pathway	0.50
NEURONS	expressed_in	concept	0.50
AMYLOID	associated_with	gene	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
AMYLOID-Β PLAQUES	associated_with	gene	0.50
AMYLOID-β	associated_with	concept	0.50
PHOSPHORYLATED TAU	associated_with	protein	0.50
NEURONS	associated_with	concept	0.50
MAPT	associated_with	gene	0.50
Alzheimer Disease	associated_with	disease	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
ALZHEIMER	causes	gene	0.50
Alzheimer'S Disease	causes	disease	0.50
disease	causes	disease	0.50
ALZHEIMER'S	causes	concept	0.50
Cortex	associated_with	brain_region	0.50
CELL DEATH	associated_with	concept	0.50
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	interacts_with	disease	0.50
Neuron	associated_with	cell_type	0.50
AMYLOID-BETA	associated_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
Mitochondrial Function	activates	pathway	0.50
Reactive Oxygen Species	activates	process	0.50
Proteins	associated_with	protein	0.50
AMYLOID BETA	interacts_with	concept	0.50
Cholesterol	associated_with	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NEUROFIBRILLARY TANGLES

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

PI-2620 Tau PET in PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

Alzheimer's Disease

NTF4 Protein

Mitochondrial Quality Control

GSK-3β in Neurodegeneration

CBS/PSP Clinical Trials Guide

Tau Spreading Mechanism

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV