While the study establishes that trehalose-induced lysosomal permeabilization activates calcium-dependent calcineurin leading to TFEB activation, the molecular basis for this specific signaling cascade is not explained. Understanding this specificity is crucial for developing targeted autophagy modulators. Gap type: unexplained_observation Source paper: Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. (2019, Autophagy, PMID:30335591)
Landscape Summary: What determines the specificity of calcium-dependent PPP3/calcineurin activation by trehalose-induced LMP? is a 0.8 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
What determines the specificity of calcium-dependent PPP3/calcineurin activation by trehalose-induced LMP? — INVOKE-2 (completed)
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