concept

ITGAV

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGAV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

38Outgoing

22Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	ITGAV
Key Genes/Proteins	FGF2, irisin, HSP90AA1, FGF2 mutant (K119E/R120E/K125E), PTK2, TUBB3
Related Diseases	Tacrolimus-Induced Chronic Nephrotoxicity, Neurodegeneration, Als, Epilepsy
Related Pathways	FGF2 signaling

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ITGAV["ITGAV"]
    ITGAV -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ITGAV -->|"expressed in"| Als["Als"]
    ITGAV -->|"expressed in"| Epilepsy["Epilepsy"]
    ITGAV -->|"inhibits"| ATG5["ATG5"]
    ITGAV -->|"inhibits"| BECN1["BECN1"]
    ITGAV -->|"inhibits"| LAMP1["LAMP1"]
    ITGAV -->|"inhibits"| ASTROCYTES["ASTROCYTES"]
    ITGAV -->|"inhibits"| PLIN3["PLIN3"]
    FGF2["FGF2"] -->|"binds"| ITGAV
    irisin["irisin"] -->|"binds_to"| ITGAV
    HSP90AA1["HSP90AA1"] -->|"activates"| ITGAV
    TUBB3["TUBB3"] -->|"activates"| ITGAV
    PLIN2["PLIN2"] -->|"inhibits"| ITGAV
    GFAP["GFAP"] -->|"interacts"| ITGAV
    ABCA1["ABCA1"] -->|"interacts"| ITGAV
    EPILEPSY["EPILEPSY"] -->|"expressed in"| ITGAV

Outgoing (38)

Target	Relation	Type	Str
FGF2	binds	protein	0.95
extracellular vesicles	targets	compound	0.90
Tacrolimus-Induced Chronic Nephrotoxicity	implicated_in	disease	0.90
FGF2 signaling	mediates	pathway	0.85
PTK2	interacts_with	gene	0.85
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Epilepsy	expressed_in	disease	0.65
BECN1	associated_with	gene	0.60
ATG5	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
LAMP1	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
FURIN	associated_with	gene	0.60
PLIN3	inhibits	gene	0.60
Astrocyte	inhibits	cell_type	0.60
LAMP1	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
PLIN2	associated_with	gene	0.60
Astrocyte	associated_with	cell_type	0.60
LRP1	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AQP4	interacts_with	gene	0.60
ERBB2	interacts_with	gene	0.60
NOTCH2	interacts_with	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
GJA1	interacts_with	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
Notch	interacts_with	pathway	0.60
Neuron	expressed_in	cell_type	0.60
Rb	interacts_with	protein	0.60
Actin	expressed_in	protein	0.60
Astrocyte	expressed_in	cell_type	0.55
Temporal Lobe	expressed_in	brain_region	0.55

Incoming (22)

Source	Relation	Type	Str
irisin	binds_to	protein	0.95
HSP90AA1	activates	gene	0.90
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.90
TUBB3	regulates	gene	0.80
TUBB3	activates	gene	0.75
LIPOPHAGY	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PLIN2	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
AND	associated_with	gene	0.60
PLIN3	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
FURIN	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
PLIN2	inhibits	gene	0.60
BECN1	associated_with	gene	0.60
GFAP	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
EPILEPSY	expressed_in	gene	0.60
YAP1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ITGAV

Understanding Entity Pages

Wiki Pages (7)

Sulfatide Metabolism in Neurodegeneration

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

Irisin Therapy — Exercise-Induced Myokine for Neurodegeneration

PECAM1 Protein

Fibrinogen and αVβ3 Integrin in Alpha-Synuclein Pathology

payload-integrin-synapse-adhesion-modulation