concept

ITGAV

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGAV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

1Hypotheses

1Analyses

39Outgoing

22Incoming

0Experiments

1Debates

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💡 Concept Info

Name	ITGAV
Key Genes/Proteins	ABCA1, Actin, AQP4, ASTROCYTES, ATG5, BECN1
Related Diseases	Als, Epilepsy

Pathway Diagram

graph TD
    ITGAV["ITGAV"]
    ITGAV -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ITGAV -->|"expressed in"| Als["Als"]
    ITGAV -->|"expressed in"| Epilepsy["Epilepsy"]
    ITGAV -->|"inhibits"| ATG5["ATG5"]
    ITGAV -->|"inhibits"| BECN1["BECN1"]
    ITGAV -->|"inhibits"| LAMP1["LAMP1"]
    ITGAV -->|"inhibits"| ASTROCYTES["ASTROCYTES"]
    ITGAV -->|"inhibits"| PLIN3["PLIN3"]
    FGF2["FGF2"] -->|"binds"| ITGAV
    irisin["irisin"] -->|"binds_to"| ITGAV
    HSP90AA1["HSP90AA1"] -->|"activates"| ITGAV
    TUBB3["TUBB3"] -->|"activates"| ITGAV
    PLIN2["PLIN2"] -->|"inhibits"| ITGAV
    GFAP["GFAP"] -->|"interacts"| ITGAV
    ABCA1["ABCA1"] -->|"interacts"| ITGAV
    EPILEPSY["EPILEPSY"] -->|"expressed in"| ITGAV

Outgoing (39)

Target	Relation	Type	Str
FGF2	binds	protein	0.95
extracellular vesicles	targets	compound	0.90
Tacrolimus-Induced Chronic Nephrotoxicity	implicated_in	disease	0.90
PTK2	interacts_with	gene	0.85
FGF2 signaling	mediates	pathway	0.85
microglial_adhesion	regulates	process	0.70
Neurodegeneration	inhibits	disease	0.65
Epilepsy	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
BECN1	associated_with	gene	0.60
Rb	interacts_with	protein	0.60
Actin	expressed_in	protein	0.60
LAMP1	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
PLIN2	associated_with	gene	0.60
Astrocyte	associated_with	cell_type	0.60
LRP1	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AQP4	interacts_with	gene	0.60
ERBB2	interacts_with	gene	0.60
NOTCH2	interacts_with	gene	0.60
ATG5	inhibits	gene	0.60
GJA1	interacts_with	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
Notch	interacts_with	pathway	0.60
Neuron	expressed_in	cell_type	0.60
ASTROCYTES	expressed_in	gene	0.60
BECN1	inhibits	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
LAMP1	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
FURIN	associated_with	gene	0.60
PLIN3	inhibits	gene	0.60
Astrocyte	inhibits	cell_type	0.60
Temporal Lobe	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55

Incoming (22)

Source	Relation	Type	Str
irisin	binds_to	protein	0.95
HSP90AA1	activates	gene	0.90
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.90
SPP1	binds_to	protein	0.90
TUBB3	regulates	gene	0.80
TUBB3	activates	gene	0.75
GFAP	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
EPILEPSY	expressed_in	gene	0.60
YAP1	interacts_with	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PLIN2	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
PLIN3	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
FURIN	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
PLIN2	inhibits	gene	0.60
BECN1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SPP1-Integrin Competitive Inhibition	0.000	-	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 13 hypotheses Top: 0.752

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

closed · Rounds: 5 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning ITGAV in their description or question text

No additional research found