concept

MONOCYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MONOCYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

1Hypotheses

2Analyses

44Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	MONOCYTE
Key Genes/Proteins	MTOR, NAD
Related Diseases	STROKE, MENINGITIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MONOCYTE["MONOCYTE"]
    MONOCYTE -->|"expressed in"| MONOCYTES["MONOCYTES"]
    MONOCYTE -->|"activates"| PARP1["PARP1"]
    MONOCYTE -->|"activates"| SIRT6["SIRT6"]
    MONOCYTE -->|"activates"| T_CELL["T CELL"]
    MONOCYTE -->|"activates"| T_CELLS["T CELLS"]
    MICROGLIA["MICROGLIA"] -.biomarker for.-> MONOCYTE
    MACROPHAGE["MACROPHAGE"] -->|"expressed in"| MONOCYTE
    MACROPHAGES["MACROPHAGES"] -->|"expressed in"| MONOCYTE
    CD38["CD38"] -->|"activates"| MONOCYTE
    ENDOTHELIAL["ENDOTHELIAL"] -->|"interacts"| MONOCYTE
    ASTROCYTE["ASTROCYTE"] -->|"activates"| MONOCYTE

Outgoing (44)

Target	Relation	Type	Str
STROKE	causes	disease	0.65
STROKE	inhibits	disease	0.65
MTOR	regulates	gene	0.65
MONOCYTES	interacts_with	cell_type	0.65
MONOCYTES	causes	cell_type	0.65
MONOCYTES	accumulates_in	cell_type	0.65
NEUTROPHIL	accumulates_in	cell_type	0.65
NEUTROPHIL	interacts_with	cell_type	0.65
MONOCYTES	sensitizes_to	cell_type	0.65
MONOCYTES	increases	cell_type	0.65
NAD	activates	gene	0.65
T CELL	interacts_with	cell_type	0.65
MONOCYTES	expressed_in	cell_type	0.60
MONOCYTES	activates	cell_type	0.60
PARP1	activates	gene	0.60
SIRT6	activates	gene	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
MONOCYTES	contributes_to	cell_type	0.60
T CELL	contributes_to	cell_type	0.60
T CELLS	contributes_to	cell_type	0.60
MONOCYTES	protects_against	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
P2RX7	activates	gene	0.60
SPINAL CORD	promotes	brain_region	0.60
WHITE MATTER	activates	brain_region	0.60
MONOCYTES	co_discussed	entity	0.50
PARP1	co_discussed	entity	0.50
SIRT6	co_discussed	entity	0.50
MONOCYTES	associated_with	concept	0.50
NEUTROPHILS	activates	concept	0.50
MONOCYTES	inhibits	concept	0.50
CELL MIGRATION	activates	concept	0.50
SPINAL CORD INJURY	activates	concept	0.50
Spinal Cord	expressed_in	brain_region	0.50
Brainstem	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
TH	co_discussed	gene	0.40
NEUTROPHIL	co_discussed	cell_type	0.40
PYCARD	co_discussed	gene	0.40
SPINAL CORD	co_discussed	brain_region	0.40
T CELL	co_discussed	cell_type	0.40
T CELLS	co_discussed	cell_type	0.40

Incoming (484)

Source	Relation	Type	Str
TNF-α	expressed_in	protein	0.95
MICROGLIA	activates	cell_type	0.82
MENINGITIS	accumulates_in	disease	0.65
MACROPHAGE	interacts_with	cell_type	0.65
MACROPHAGES	interacts_with	cell_type	0.65
MACROPHAGE	sensitizes_to	cell_type	0.65
MACROPHAGES	sensitizes_to	cell_type	0.65
IL-6	mediates	gene	0.65
CCL2	activates	gene	0.65
MACROPHAGE	causes	cell_type	0.65
MACROPHAGES	causes	cell_type	0.65
ATHEROSCLEROSIS	reduces	disease	0.65
DIABETES	expressed_in	disease	0.65
DIABETES	causes	disease	0.65
CD38	promotes	gene	0.65
IL-10	promotes	gene	0.65
DENDRITIC CELL	interacts_with	cell_type	0.65
MICROGLIA	promotes	cell_type	0.65
MICROGLIA	biomarker_for	cell_type	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
CD38	activates	gene	0.60
MACROPHAGE	activates	cell_type	0.60
MACROPHAGES	activates	cell_type	0.60
CD38	treats	gene	0.60
MACROPHAGE	treats	cell_type	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
ASTROCYTE	activates	cell_type	0.60
ASTROCYTES	activates	cell_type	0.60
CCL2	regulates	gene	0.60
MICROGLIA	expressed_in	cell_type	0.60
LDLR	expressed_in	gene	0.60
MACROPHAGE	inhibits	cell_type	0.60
MACROPHAGES	inhibits	cell_type	0.60
MICROGLIA	contributes_to	cell_type	0.60
TMEM119	biomarker_for	gene	0.60
GAIN	biomarker_for	gene	0.60
FCRLS	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
MICROGLIA	associated_with	gene	0.60
KCNK2	associated_with	gene	0.60
WNT	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
SCN1A	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
SCN5A	associated_with	gene	0.60
PIEZO1	expressed_in	gene	0.60
CACNA1B	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MONOCYTE

Understanding Entity Pages

Wiki Pages (20)

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Blood-Brain Barrier Dysfunction in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Biology and Crossing Strategies

substantia-nigra

nlrc5-protein

LRRK2 Pathway in Parkinson's Disease

NPAS3 Gene

Ion Channel Dysfunction in Huntington's Disease

Transcriptional Regulation in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Meningeal Lymphatics