concept

DENDRITIC CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENDRITIC CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

461Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

Summary

DENDRITIC CELL is a concept in neurodegeneration research. Key relationships include: activates, interacts with, co discussed. Associated with CANCER, TUMOR. Connected to 31 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DENDRITIC CELL
Key Genes/Proteins	LC3, MTOR, NLRP3, PYCARD, RIPK3, TNF
Related Diseases	TUMOR

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DENDRITIC_CELL["DENDRITIC CELL"]
    MAPK["MAPK"] -->|"activates"| DENDRITIC_CELL
    ROS["ROS"] -->|"expressed in"| DENDRITIC_CELL
    RICTOR["RICTOR"] -->|"expressed in"| DENDRITIC_CELL
    MTOR["MTOR"] -->|"expressed in"| DENDRITIC_CELL
    MAP1LC3A["MAP1LC3A"] -->|"expressed in"| DENDRITIC_CELL
    LC3["LC3"] -->|"expressed in"| DENDRITIC_CELL
    DNA["DNA"] -->|"expressed in"| DENDRITIC_CELL
    RHEB["RHEB"] -->|"expressed in"| DENDRITIC_CELL
    LYSOSOME["LYSOSOME"] -->|"expressed in"| DENDRITIC_CELL
    MAVS["MAVS"] -->|"expressed in"| DENDRITIC_CELL

Outgoing (62)

Target	Relation	Type	Str
TUMOR	activates	disease	0.65
LC3	associated_with	gene	0.65
MTOR	activates	gene	0.65
NLRP3	activates	gene	0.65
PYCARD	activates	gene	0.65
RIPK3	activates	gene	0.65
TNF	activates	gene	0.65
ULK1	activates	gene	0.65
IFNG	interacts_with	gene	0.65
OPTN	phosphorylates	gene	0.65
PI3K	phosphorylates	gene	0.65
RIPK1	phosphorylates	gene	0.65
ROS	phosphorylates	gene	0.65
SQSTM1	phosphorylates	gene	0.65
STAT3	phosphorylates	gene	0.65
STING	phosphorylates	gene	0.65
TFEB	phosphorylates	gene	0.65
MONOCYTE	interacts_with	cell_type	0.65
ROS	activates	gene	0.65
EGF	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
JNK	activates	gene	0.60
LC3	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
MAPK	activates	gene	0.60
MLKL	activates	gene	0.60
MTOR	interacts_with	gene	0.60
OPTN	activates	gene	0.60
PI3K	activates	gene	0.60
RAS	activates	gene	0.60
RB1	activates	gene	0.60
RIPK1	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
STING	activates	gene	0.60
TFEB	activates	gene	0.60
MACROPHAGE	associated_with	cell_type	0.60
MACROPHAGES	associated_with	cell_type	0.60
TUMOR	associated_with	disease	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
MICROGLIA	expressed_in	cell_type	0.60
CANCER	activates	disease	0.50
AUTOPHAGY	activates	process	0.50
RAPAMYCIN	activates	drug	0.50
MACROPHAGE	co_discussed	cell_type	0.40
MACROPHAGES	co_discussed	cell_type	0.40
MONOCYTE	co_discussed	cell_type	0.40
MONOCYTES	co_discussed	cell_type	0.40
T CELL	co_discussed	cell_type	0.40
T CELLS	co_discussed	cell_type	0.40

Incoming (399)

Source	Relation	Type	Str
CANCER	activates	disease	0.65
CGAS	activates	gene	0.65
BECN1	associated_with	gene	0.65
CANCER	associated_with	disease	0.65
CANCER	causes	disease	0.60
MTOR	activates	gene	0.50
PI3K	activates	gene	0.50
NLRP3	activates	gene	0.50
TNF	activates	gene	0.50
STAT3	activates	gene	0.50
BECN1	activates	gene	0.50
ULK1	activates	gene	0.50
LC3	activates	gene	0.50
SQSTM1	activates	gene	0.50
RIPK3	activates	gene	0.50
MAPK	activates	gene	0.50
LRRK2	activates	gene	0.50
TFEB	activates	gene	0.50
HMGB1	activates	gene	0.50
EGFR	activates	gene	0.50
RAS	activates	gene	0.50
RB1	activates	gene	0.50
OPTN	activates	gene	0.50
RIPK1	activates	gene	0.50
MLKL	activates	gene	0.50
JNK	activates	gene	0.50
P38	activates	gene	0.50
B CELL	co_discussed	cell_type	0.40
CANCER	co_discussed	disease	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DENDRITIC CELL

Understanding Entity Pages

Summary

Wiki Pages (20)

TREM2 Microglial Signaling Pathway in Neurodegeneration

nlrc5-protein

Histamine

Exosome and Extracellular Vesicle Brain Delivery

Gut-Microbiome-Neurodegeneration Axis

Meningeal Lymphatics

IL28B (Interleukin 28B)

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

Adaptive Immunity in Neurodegeneration

CD200R1 Gene

Exosome Biogenesis in Neurodegeneration

NICASTRIN Gene

Subacute Sclerosing Panencephalitis (SSPE)

CTS Gene - Cathepsin S

Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Admini... (NCT03899298)

IL3 (Interleukin 3)

Intercellular Adhesion Molecule-5 Protein

CD33 — Cluster of Differentiation 33