concept

SPINAL CORD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPINAL CORD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1024Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SPINAL CORD is a concept in neurodegeneration research. Key relationships include: co discussed, activates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SPINAL CORD
Key Genes/Proteins	PARP1, TDP-43, STING, SOD1
Related Diseases	ALS, ASTROGLIOSIS

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    SPINAL_CORD["SPINAL CORD"]
    MAP1LC3B["MAP1LC3B"] -->|"expressed in"| SPINAL_CORD
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"expressed in"| SPINAL_CORD
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"expressed in"| SPINAL_CORD
    NF__B["NF-KappaB"] -->|"expressed in"| SPINAL_CORD
    MTDNA["MTDNA"] -->|"expressed in"| SPINAL_CORD
    DNA["DNA"] -->|"expressed in"| SPINAL_CORD
    IFN["IFN"] -->|"expressed in"| SPINAL_CORD
    MITOCHONDRIA["MITOCHONDRIA"] -->|"expressed in"| SPINAL_CORD
    CGAS["CGAS"] -->|"expressed in"| SPINAL_CORD
    ALS["ALS"] -->|"expressed in"| SPINAL_CORD

Outgoing (240)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.95
ALS	treats	disease	0.70
PERICYTE	inhibits	cell_type	0.70
ASTROGLIOSIS	regulates	phenotype	0.70
ASTROGLIOSIS	treats	phenotype	0.70
T CELL	activates	cell_type	0.65
TDP-43	expressed_in	gene	0.65
STING	biomarker_for	gene	0.65
SOD1	regulates	gene	0.65
SOD1	produces	gene	0.65
OLIGODENDROCYTES	produces	cell_type	0.65
NEURON	protects_against	cell_type	0.65
MICROGLIA	causes	cell_type	0.65
BDNF	inhibits	gene	0.65
BDNF	treats	gene	0.65
NEUROINFLAMMATION	interacts_with	phenotype	0.65
NEURONS	causes	cell_type	0.65
ASTROGLIOSIS	inhibits	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
GAS6	activates	gene	0.65
GAS6	regulates	gene	0.65
ASTROCYTES	causes	cell_type	0.65
MAPK	regulates	gene	0.65
APOPTOSIS	inhibits	phenotype	0.65
STING	activates	gene	0.60
SQSTM1	activates	gene	0.60
TARDBP	activates	gene	0.60
TFEB	activates	gene	0.60
TLR4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
TDP-43	depleted_in	gene	0.60
APOPTOSIS	depleted_in	phenotype	0.55
STING	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
TARDBP	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
TLR4	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
STEM CELLS	activates	cell_type	0.50
WHITE MATTER	activates	brain_region	0.50
OLAPARIB	associated_with	drug	0.50
PARP1	associated_with	gene	0.50
TET2	associated_with	gene	0.50
CHAT	associated_with	gene	0.50
APP	associated_with	gene	0.50
HDAC1	associated_with	gene	0.50
HDAC2	associated_with	gene	0.50
HDAC6	associated_with	gene	0.50
CHOLESTEROL	associated_with	phenotype	0.50

Incoming (784)

Source	Relation	Type	Str
OLAPARIB	causes	drug	0.70
PARP1	inhibits	gene	0.70
TDP-43	causes	gene	0.70
PERICYTE	activates	cell_type	0.70
PERICYTE	causes	cell_type	0.70
HYPOTHALAMUS	regulates	brain_region	0.70
ALS	regulates	disease	0.65
C9ORF72	regulates	gene	0.65
MOTOR NEURON	reduces	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
OPTN	causes	gene	0.65
MICROGLIA	activates	cell_type	0.65
CORTEX	expressed_in	brain_region	0.65
MOTOR NEURON	expressed_in	cell_type	0.65
NEURONS	expressed_in	cell_type	0.65
NEUTROPHIL	increases	cell_type	0.65
ALS	reduces	disease	0.65
CEREBELLUM	accumulates_in	brain_region	0.65
CORTEX	accumulates_in	brain_region	0.65
RAPAMYCIN	targets	drug	0.65
NEUTROPHIL	inhibits	cell_type	0.65
BRAINSTEM	protects_against	brain_region	0.65
EPILEPSY	protects_against	disease	0.65
NEURON	impairs	cell_type	0.65
RAPAMYCIN	expressed_in	drug	0.65
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.65
C9ORF72	causes	gene	0.65
BRAINSTEM	inhibits	brain_region	0.65
NEURONS	inhibits	cell_type	0.65
TLR4	causes	gene	0.65
CD47	treats	gene	0.65
MMP9	causes	gene	0.65
NEUROPATHY	activates	disease	0.65
BDNF	activates	gene	0.65
AMYLOID	regulates	protein	0.65
REMYELINATION	regulates	phenotype	0.65
MICROGLIA	exacerbates	cell_type	0.65
AMYOTROPHIC LATERAL SCLEROSIS	targets	disease	0.65
REMYELINATION	activates	phenotype	0.65
TMEM106B	causes	gene	0.65
MLKL	activates	gene	0.65
NEURON	interacts_with	cell_type	0.65
NEURON	produces	cell_type	0.65
NRF2	regulates	gene	0.65
HIPPOCAMPUS	protects_against	brain_region	0.65
NEURONS	regulates	cell_type	0.65
SODIUM BUTYRATE	treats	drug	0.65
OLIGODENDROCYTE	causes	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SPINAL CORD

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

calcium-dysregulation-comparison

nhp-validation-animal-model

nimodipine-als

Therapeutics

NPM1 Gene

Neurons — Cell Type Hierarchy

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

NTF4 Protein

Astrocyte Reactivity Mechanism

HNRNPA2B1 Protein

ALS Failed Approaches Analysis

Autophagy Mechanisms

cerebral-cortical-vasal-neurons

Mitophagy Pathway in Neurodegeneration