disease

ATHEROSCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATHEROSCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2103Connections

0Hypotheses

4Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	BMAL1, APP, HIF1A, LDLR
Therapeutic Agents	CURCUMIN
KG Connections	222 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGE["MACROPHAGE"]
    style MACROPHAGE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| MACROPHAGES["MACROPHAGES"]
    style MACROPHAGES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"causes"| ENDOTHELIAL["ENDOTHELIAL"]
    style ENDOTHELIAL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"promotes"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -.->|"reduces"| LDLR["LDLR"]
    style LDLR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"expressed in"| DIABETES["DIABETES"]
    style DIABETES fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    C1Q["C1Q"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1Q fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QA["C1QA"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    C1QC["C1QC"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style C1QC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    MACROPHAGE_1["MACROPHAGE"] -->|"contributes to"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style MACROPHAGE_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"associated"| ATHEROSCLEROSIS["ATHEROSCLEROSIS"]
    style APOE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ATHEROSCLEROSIS fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (596)

Target	Relation	Type	Str
MACROPHAGES	activates	cell_type	0.80
MACROPHAGE	promotes	cell_type	0.65
MACROPHAGES	promotes	cell_type	0.65
MACROPHAGE	associated_with	cell_type	0.65
MACROPHAGES	associated_with	cell_type	0.65
MACROPHAGES	regulates	cell_type	0.65
ENDOTHELIAL	causes	cell_type	0.65
PI3K	promotes	gene	0.65
LDLR	reduces	gene	0.65
ENDOTHELIAL	processes	cell_type	0.65
MACROPHAGE	processes	cell_type	0.65
MACROPHAGES	processes	cell_type	0.65
DIABETES	expressed_in	disease	0.65
MONOCYTE	reduces	cell_type	0.65
MONOCYTES	reduces	cell_type	0.65
MACROPHAGES	implicated_in	cell_type	0.65
ATP	interacts_with	gene	0.65
TNF	activates	gene	0.65
DIABETES	associated_with	disease	0.65
STING	associated_with	gene	0.65
STROKE	causes	disease	0.65
MONOCYTES	interacts_with	cell_type	0.65
SPHINGOLIPIDS	inhibits	phenotype	0.65
INFLAMMATION	causes	phenotype	0.64
P2RY12	inhibits	gene	0.60
P2RY12	regulates	gene	0.60
P2RY12	activates	gene	0.60
LC3	activates	gene	0.60
P2RY12	targets	gene	0.60
P62	activates	gene	0.60
SQSTM1	activates	gene	0.60
ULK1	activates	gene	0.60
MACROPHAGE	contributes_to	cell_type	0.60
MACROPHAGES	contributes_to	cell_type	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGE	inhibits	cell_type	0.60
MACROPHAGES	inhibits	cell_type	0.60
STING	inhibits	gene	0.60
MACROPHAGES	targets	cell_type	0.60
LDLR	targets	gene	0.60
ERK	inhibits	gene	0.60
DIABETES	regulates	disease	0.60
DIABETES	treats	disease	0.60
MACROPHAGE	treats	cell_type	0.60
MACROPHAGES	treats	cell_type	0.60
LDLR	expressed_in	gene	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
STAT3	regulates	gene	0.60
DEMENTIA	associated_with	disease	0.60

Incoming (1507)

Source	Relation	Type	Str
C1Q	associated_with	entity	0.95
C1QA	associated_with	entity	0.90
C1QC	associated_with	entity	0.90
MACROPHAGE	contributes_to	entity	0.90
HIF1A	associated_with	gene	0.85
APOE	associated_with	entity	0.85
COMPLEMENT SIGNALING PATHWAY	involved_in	entity	0.85
CLOCK	associated_with	entity	0.75
IL13RA1	contributes_to	gene	0.68
APOE	mediates	gene	0.65
P2RY12	treats	gene	0.65
MACROPHAGE	causes	cell_type	0.65
LDLR	causes	gene	0.65
MACROPHAGE	exacerbates	cell_type	0.65
DIABETES	exacerbates	disease	0.65
NRF2	produces	gene	0.65
CURCUMIN	treats	drug	0.65
LUTEOLIN	inhibits	drug	0.65
ABCA1	interacts_with	gene	0.60
ALS	activates	disease	0.60
BMAL1	associated_with	gene	0.56
TNF	participates_in	gene	0.55
ASPIRIN	associated_with	drug	0.45
ALZHEIMER'S DISEASE	causes	disease	0.44
APOE	co_discussed	gene	0.40
AKT	co_discussed	gene	0.40
ALZHEIMER	co_discussed	disease	0.40
ALZHEIMER'S	co_discussed	disease	0.40
ALZHEIMER'S DISEASE	co_discussed	disease	0.40
ACHE	co_discussed	gene	0.40
ABCA1	co_discussed	gene	0.40
ALS	co_discussed	disease	0.40
AMPK	co_discussed	gene	0.40
ATG5	co_discussed	gene	0.40
APP	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
LATE	co_discussed	disease	0.40
P2Y12 RECEPTOR	co_discussed	protein	0.40
APP	implicated_in	gene	0.35
ALZHEIMER'S DISEASE	regulates	disease	0.35
LIPID METABOLISM	associated_with	process	0.30
OXIDATIVE PHOSPHORYLATION	inhibits	process	0.30
GLYCOLYSIS	inhibits	process	0.30
INNATE IMMUNITY	associated_with	process	0.30
INNATE IMMUNITY	inhibits	process	0.30
DIABETES	implicated_in	disease	0.30
INFLAMMASOME	inhibits	protein	0.30
INFLAMMASOME	activates	protein	0.30
AGING	biomarker_for	process	0.30
SENESCENCE	implicated_in	process	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

neuroinflammation | 2026-04-08 | 0 hypotheses

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

What determines P2RY12 receptor expression/activity specifically in VSMCs during

neurodegeneration | 2026-04-07 | 0 hypotheses

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATHEROSCLEROSIS

Understanding Entity Pages

Wiki Pages (20)

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MAPK/ERK Signaling Pathway in Neurodegeneration

ATF3 Protein

Metabolic Dysfunction in Alzheimer's Disease

PPP1R15B

AKT2 Gene

ERK1 Protein

Glymphatic System and Aβ Clearance in Alzheimer's Disease

Neuritic Plaques

one-carbon-metabolism-neurodegeneration

ZBP1 (Z-DNA Binding Protein 1)

Ferroptosis in Alzheimer's Disease

cxcr4