concept

CELLULAR SENESCENCE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELLULAR SENESCENCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	CELLULAR SENESCENCE
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CELLULAR_SENESCENCE["CELLULAR SENESCENCE"]
    style CELLULAR_SENESCENCE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CELLULAR_SENESCENCE -->|"involved_in"| Cardiac_Aging["Cardiac Aging"]
    CELLULAR_SENESCENCE -->|"causes"| Cell_Cycle_Arrest(Cell Cycle Arrest)
    CELLULAR_SENESCENCE -->|"causes"| Apoptosis_Resistance(Apoptosis Resistance)
    CELLULAR_SENESCENCE -->|"causes"| Senescence_Associated_Secretor(Senescence-Associated Secretory Phenotype)
    CELLULAR_SENESCENCE -->|"causes"| cell_cycle_arrest(cell cycle arrest)
    CELLULAR_SENESCENCE -->|"promotes"| pro_inflammatory_molecules["pro-inflammatory molecules"]
    CELLULAR_SENESCENCE -->|"expressed in"| Dopaminergic_Neurons["/Dopaminergic Neurons/"]
    CELLULAR_SENESCENCE -->|"mediates"| Senescence_Associated_Secretom["Senescence-Associated Secretome"]
    CELLULAR_SENESCENCE -->|"involved_in"| Biological_Aging["Biological Aging"]
    CELLULAR_SENESCENCE -->|"contributes to"| Aging["Aging"]
    Lipid_Accumulation["Lipid Accumulation"] -->|"causes"| CELLULAR_SENESCENCE
    AMPK([AMPK]) -->|"regulates"| CELLULAR_SENESCENCE
    LIPID_ACCUMULATION["LIPID ACCUMULATION"] -->|"causes"| CELLULAR_SENESCENCE
    Telomere_Dysfunction["Telomere Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    PGAM5([PGAM5]) -->|"modulates"| CELLULAR_SENESCENCE
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"] -->|"causes"| CELLULAR_SENESCENCE
    P53([P53]) -->|"promotes"| CELLULAR_SENESCENCE
    cGAS_STING["cGAS/STING"] -->|"regulates"| CELLULAR_SENESCENCE
    cGAS_STING_signaling_pathway["cGAS/STING signaling pathway"] -->|"regulates"| CELLULAR_SENESCENCE
    Ginkgetin{"Ginkgetin"} -.->|"prevents"| CELLULAR_SENESCENCE

Outgoing (88)

Target	Relation	Type	Str
cell cycle arrest	causes	phenotype	0.95
pro-inflammatory molecules	promotes	pathway	0.95
senescence-associated secretory phenotype	drives	phenotype	0.95
DOPAMINERGIC NEURONS	associated_with	entity	0.95
Cardiac Aging	involved_in	process	0.95
Cell Cycle Arrest	causes	phenotype	0.95
Apoptosis Resistance	causes	phenotype	0.95
Senescence-Associated Secretory Phenotype	causes	phenotype	0.95
aging	associated_with	process	0.95
ALZHEIMER'S DISEASE	causes	disease	0.95
PARKINSON'S DISEASE	causes	disease	0.95
Inflammation	promotes	process	0.95
Neurodegeneration	associated_with	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer Disease	contributes_to	disease	0.95
Alzheimer'S Disease Pathology	mediates	mechanism	0.92
senescence-related disorders	causes	disease	0.90
neurodegenerative disorders	contributes_to	disease	0.90
Dopaminergic Neurons	expressed_in	cell_type	0.90
Senescence-Associated Secretome	mediates	pathway	0.90
Biological Aging	involved_in	process	0.90
Aging	contributes_to	process	0.90
Chronic Aging-Related Diseases	contributes_to	disease	0.90
Senescence Biomarkers	biomarker_for	biomarker	0.90
Chronic Inflammation	contributes_to	process	0.90
Aging	involved_in	process	0.90
Biological Aging	mediates	process	0.90
Senescence-Associated Secretory Phenotype	mediates	phenotype	0.90
Senescence-Associated Secretory Phenotype	associated_with	phenotype	0.90
Inflammaging	contributes_to	process	0.90
Neuroinflammation	contributes_to	process	0.90
Embryonic Development	involved_in	process	0.90
Wound Healing	involved_in	process	0.90
Obesity	associated_with	disease	0.90
Inflammation	causes	process	0.90
NEURODEGENERATION	contributes_to	process	0.90
AGING	associated_with	process	0.90
Cellular Dysfunction	contributes_to	phenotype	0.90
Neuroinflammation	promotes	process	0.90
Neurodegenerative Diseases	contributes_to	disease	0.90
Osteoarthritis	contributes_to	disease	0.88
Cognitive Deficits	causes	phenotype	0.88
Myocardial Ischemia And Infarction	involved_in	disease	0.87
neurodegeneration	promotes	disease	0.85
Heart Failure	involved_in	disease	0.85
Myocardial Ischemia	involved_in	disease	0.85
Myocardial Infarction	involved_in	disease	0.85
Myocardial Ischemia and Infarction	involved_in	disease	0.85
Aging	associated_with	process	0.85

Incoming (218)

Source	Relation	Type	Str
cGAS/STING signaling pathway	regulates	pathway	0.95
Lipid Accumulation	causes	process	0.95
AMPK	regulates	protein	0.95
LIPID ACCUMULATION	causes	entity	0.95
Telomere Dysfunction	causes	mechanism	0.95
PGAM5	modulates	protein	0.95
Mitochondrial Dysfunction	causes	process	0.95
Ginkgetin	associated_with	compound	0.95
MIR-302B	associated_with	gene	0.95
P53	promotes	protein	0.95
cGAS/STING	regulates	pathway	0.95
Ginkgetin	inhibits	compound	0.95
Mir-302B	associated_with	biomarker	0.95
Cgas/Sting Signaling	regulates	pathway	0.95
Lipid Accumulation	promotes	process	0.95
Dasatinib	inhibits	drug	0.95
Quercetin	inhibits	compound	0.95
aging	drives	process	0.95
Alzheimer'S Disease	associated_with	disease	0.95
SRT2104	suppresses	drug	0.93
Ginkgetin	prevents	drug	0.92
STING	regulates	protein	0.92
SQSTM1	prevents	gene	0.90
oncogene-induced stress	causes	process	0.90
lipid accumulation	drives	process	0.90
senolytics	targets	drug	0.90
apoptosis resistance	associated_with	phenotype	0.90
H₂O₂	causes	compound	0.90
autophagy	suppresses	process	0.90
Glucocerebrosides	causes	compound	0.90
Obesity	associated_with	phenotype	0.90
Metabolic Reprogramming	associated_with	process	0.90
PLIN2	associated_with	entity	0.90
Prediabetes	associated_with	disease	0.90
SIRT1	regulates	gene	0.90
mitophagy	protects_against	process	0.90
IL23R	biomarker_for	protein	0.90
iPSC Reprogramming	associated_with	process	0.90
Partial Reprogramming	associated_with	process	0.90
Lysosomal Impairment	associated_with	process	0.90
MTOR	involved_in	gene	0.90
Microglia	involved_in	cell_type	0.90
Astrocytes	involved_in	cell_type	0.90
SDA-2026-04-01-gap-013	investigates	analysis	0.90
Intermittent Fasting	modulates	drug	0.90
CDKN1A	associated_with	protein	0.90
CDKN2A	associated_with	protein	0.90
BHB	suppresses	compound	0.90
STING	promotes	protein	0.88
Hayflick Limit	biomarker_for	biomarker	0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.790

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.736

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CELLULAR SENESCENCE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Device Therapies Comparison for CBS/PSP

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD) Mechanistic Pathway

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV

University of Heidelberg

rankings

VEGF/Angiogenesis Pathway in Neurodegeneration

Epigenetic Dysregulation in Neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Locus Coeruleus Alpha Neurons

Protein Aggregation Comparison in Neurodegeneration

NPAS3 Gene

GBA1→GCase→Lysosome→PD Causal Chain