disease

Coronary Artery Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Coronary Artery Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	OXIDATIVE STRESS, DIABETES MELLITUS, MET, STROKE, MITOCHONDRIAL DYSFUNCTION, ROS, SORLA, SORCS1
Therapeutic Agents	Anti-Inflammatory Therapies
KG Connections	189 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Heart_Failure["Heart Failure"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"therapeutic target"| Inflammation["Inflammation"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Stroke["Stroke"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"activates"| Cholesterol["Cholesterol"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"therapeutic target"| Atherosclerosis["Atherosclerosis"]
    Coronary_Artery_Disease["Coronary Artery Disease"] -->|"associated"| Atherosclerosis_1["Atherosclerosis"]
    Cardiovascular["Cardiovascular"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    INFLAMMATION["INFLAMMATION"] -->|"therapeutic target"| Coronary_Artery_Disease["Coronary Artery Disease"]
    STROKE["STROKE"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated"| Coronary_Artery_Disease["Coronary Artery Disease"]
    style Coronary_Artery_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
Heart Failure	associated_with	disease	1.00
Inflammation	therapeutic_target	disease	0.95
Stroke	associated_with	disease	0.85
Cholesterol	activates	pathway	0.80
Atherosclerosis	therapeutic_target	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Type 2 Diabetes	activates	disease	0.75
Oxidative Stress	associated_with	pathway	0.70
Obesity	associated_with	disease	0.65
Heart Failure	activates	disease	0.65
Als	causes	disease	0.65
Cardiovascular	causes	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Nf-Κb	therapeutic_target	pathway	0.60
Oxidative Stress	causes	pathway	0.60
Mitochondrial Function	causes	pathway	0.60
Complement	therapeutic_target	pathway	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60
Mitochondrial Function	contributes_to	pathway	0.60
Cholesterol	inhibits	pathway	0.60
Gut Microbiome	therapeutic_target	pathway	0.60
Cholesterol	causes	pathway	0.60
Complement	causes	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
Lipid Metabolism	implicated_in	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Microrna	regulates	pathway	0.60
Atherosclerosis	activates	disease	0.55
Stroke	causes	disease	0.55
Type 2 Diabetes	causes	disease	0.55
Alzheimer	associated_with	disease	0.55
Stroke	therapeutic_target	disease	0.55
Type 2 Diabetes	therapeutic_target	disease	0.55
Atherosclerosis	causes	disease	0.55
Aging	causes	disease	0.55
Longevity	associated_with	disease	0.55
Aging	therapeutic_target	disease	0.55
Inflammation	contributes_to	disease	0.55
Insulin Resistance	associated_with	disease	0.55
Arrhythmia	associated_with	disease	0.55
Stroke	protects_against	disease	0.55
Inflammation	biomarker_for	disease	0.55
Cardiovascular	therapeutic_target	disease	0.55
Insulin Resistance	therapeutic_target	disease	0.55
Stroke	contributes_to	disease	0.55
Atherosclerosis	contributes_to	disease	0.55

Incoming (132)

Source	Relation	Type	Str
Cardiovascular	associated_with	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
STROKE	associated_with	gene	0.95
CCR9	biomarker_for	gene	0.95
IL13RA1	biomarker_for	gene	0.95
MMP9	biomarker_for	gene	0.95
TNFRSF19	biomarker_for	gene	0.90
MSR1	biomarker_for	gene	0.90
Atherosclerosis	causes	disease	0.90
Peripheral Immune Cells	associated_with	cell_type	0.85
Immune Response	associated_with	process	0.85
CHIP	risk_factor_for	process	0.85
Anti-Inflammatory Therapies	treats	drug	0.82
OXIDATIVE STRESS	associated_with	gene	0.75
Hypertension	associated_with	disease	0.75
Als	associated_with	disease	0.75
GENES	therapeutic_target	gene	0.75
Diabetes	activates	disease	0.75
Myocardial Infarction	associated_with	disease	0.75
Als	therapeutic_target	disease	0.75
LDL	associated_with	gene	0.75
INFLAMMATION	associated_with	gene	0.75
APOE	associated_with	gene	0.75
DIABETES MELLITUS	associated_with	gene	0.65
ROS	interacts_with	gene	0.65
Diabetes	associated_with	disease	0.65
MET	associated_with	gene	0.65
ICAM1	therapeutic_target	gene	0.65
TNF	therapeutic_target	gene	0.65
NF-ΚB	therapeutic_target	gene	0.65
PTGS2	therapeutic_target	gene	0.65
TNF-Α	therapeutic_target	gene	0.65
MMP9	therapeutic_target	gene	0.65
APOE	therapeutic_target	gene	0.65
ERK1	activates	gene	0.65
JUN	activates	gene	0.65
C-JUN	activates	gene	0.65
JNK	activates	gene	0.65
OXIDATIVE STRESS	causes	gene	0.65
STROKE	causes	gene	0.65
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.65
ROS	causes	gene	0.65
SORLA	implicated_in	gene	0.65
SORCS1	implicated_in	gene	0.65
ALZHEIMER	associated_with	gene	0.65
AMYLOID	implicated_in	gene	0.65
ALZHEIMER'S DISEASE	associated_with	gene	0.65
APP	implicated_in	gene	0.65
Als	implicated_in	disease	0.65
STROKE	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Coronary Artery Disease

Understanding Entity Pages

Wiki Pages (20)

williams-syndrome

Binswanger Disease

Epigenetic Regulation

APOC1 Gene — Apolipoprotein C-I

HDAC9 Protein

PON3 — Paraoxonase 3

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

HDAC9 Gene

MTR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase)

GNB3 Gene

PECAM1 Protein

NPY2R — Neuropeptide Y Receptor Y2

MMP12 - Matrix Metallopeptidase 12

DYRK1B — Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B

Morquio A Syndrome

Dementia with Lewy Bodies Diagnostic Methods

Estrogen Replacement Therapy for Neurodegeneration

SORCS1 Gene