concept

DENDRITE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENDRITE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

174Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	DENDRITE
Related Diseases	Als, Amyotrophic Lateral Sclerosis, Neurodegeneration, Alzheimer, Depression

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DENDRITE["DENDRITE"]
    DENDRITE -->|"interacts"| NEURON["NEURON"]
    DENDRITE -->|"activates"| Als["Als"]
    DENDRITE -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    DENDRITE -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    DENDRITE -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    DENDRITE -->|"regulates"| LRP1["LRP1"]
    Activity_Evoked_Intracellular_["Activity-Evoked Intracellular Signals"] -->|"expressed in"| DENDRITE
    AXON["AXON"] -->|"interacts"| DENDRITE
    LRP1 -->|"regulates"| DENDRITE
    BDNF["BDNF"] -->|"activates"| DENDRITE
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"expressed in"| DENDRITE
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| DENDRITE

Outgoing (112)

Target	Relation	Type	Str
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Depression	regulates	disease	0.65
Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Huntington	inhibits	disease	0.65
Spinocerebellar Ataxia	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
ALS	contributes_to	disease	0.65
ALS	expressed_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
LRP1	co_discussed	gene	0.60
LRP1	regulates	gene	0.60
BDNF	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
HSPA8	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEPRESSION	regulates	gene	0.60
AXON	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
Synaptic Plasticity	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
DEMENTIA	regulates	gene	0.60
Microglia	associated_with	cell_type	0.60
Astrocyte	associated_with	cell_type	0.60
Stem Cell	expressed_in	cell_type	0.60
CYP46A1	therapeutic_target	gene	0.60

Incoming (62)

Source	Relation	Type	Str
NEUROFEEDBACK	upregulates	treatment	0.80
LRP1	regulates	gene	0.60
BDNF	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
AND	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
DEPRESSION	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MICROTUBULES	expressed_in	gene	0.60
SYNCRIP	expressed_in	gene	0.60
AMYLOID	activates	gene	0.60
APOE3	activates	gene	0.60
WNT	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
AXON	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
MICROTUBULES	transports	gene	0.60
AND	expressed_in	gene	0.60
SEMA3F	activates	gene	0.60
LRP5	activates	gene	0.60
LRP1	activates	gene	0.60
ALZHEIMER	co_discussed	gene	0.60
ASTROCYTE	co_discussed	gene	0.60
AXON	co_discussed	gene	0.60
DEMENTIA	associated_with	gene	0.60
CYP46A1	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APP	associated_with	gene	0.60
late	protects_against	disease	0.50
microglia	protects_against	cell_type	0.50
ALZHEIMER	protects_against	gene	0.50
Alzheimer'S Disease	protects_against	disease	0.50
Astrocyte	protects_against	cell_type	0.50
disease	protects_against	disease	0.50
ALZHEIMER'S	protects_against	concept	0.50
Chaperone	associated_with	pathway	0.50
Proteostasis	associated_with	process	0.50
MOTOR NEURONS	activates	concept	0.50
Spinal Cord	activates	cell_type	0.50
Chaperone	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DENDRITE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Atypical Parkinsonism

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Neuroresilience Mechanisms and Evidence

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

GRIA3 Gene

Frontotemporal Dementia (FTD)

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

Mitochondrial Quality Control

williams-syndrome

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein