protein

FLT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

17Incoming

0Experiments

Summary

FLT1 is a protein involved in neurodegeneration research. Key relationships include: activates, biomarker for, interacts with. Associated with Cardiac, Inflammation, Ischemia. Connected to 17 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FLT1
Full Name	Fms Related Receptor Tyrosine Kinase 1 (VEGF Receptor 1)
Aliases	VEGF Receptor 1
Chromosome	13q12.3
Protein Type	Receptor
Function	The first three Ig domains are sufficient for VEGF binding, while domains 2-3 are critical for high-affinity interactions.
Molecular Weight	180 kDa
Pathways	Angiogenesis, Erk Signaling, Mapk, epigenetic regulation, oxidative stress response
UniProt ID	P17948
NCBI Gene ID	2321
Ensembl ID	ENSG00000102755
OMIM	165040
GeneCards	FLT1
Human Protein Atlas	FLT1
Associated Diseases	neurodegeneration
Interactions	HSPA8, IL1B, TAU, INFLAMMATION, ERK, MICROGLIA
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FLT1 — AlphaFold P17948 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

FLT1 Gene

gene · 2316 words

→

VEGF/Angiogenesis Pathway in Neurodegeneration

mechanism · 4480 words

→

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

company · 2020 words

→

Pathway Diagram

graph TD
    FLT1["<b>FLT1</b>"]
    Ms{"Ms"}
    FLT1 -->|"biomarker for"| Ms
    HSPA8["HSPA8"]
    FLT1 -->|"interacts with"| HSPA8
    GPX4["GPX4"]
    FLT1 -->|"biomarker for"| GPX4
    Ferroptosis(["Ferroptosis"])
    FLT1 -->|"biomarker for"| Ferroptosis
    neurodegeneration["neurodegeneration"]
    FLT1 -->|"implicated in"| neurodegeneration
    ENO1["ENO1"]
    ENO1 -->|"interacts with"| FLT1
    DNAJA1["DNAJA1"]
    DNAJA1 -->|"biomarker for"| FLT1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"biomarker for"| FLT1
    HSPA1A["HSPA1A"]
    HSPA1A -->|"interacts with"| FLT1
    style FLT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
MICROGLIA	expressed_in	cell_type	0.90
Ms	biomarker_for	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiac	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Hypertension	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
ALS	expressed_in	disease	0.65
Hypertension	therapeutic_target	disease	0.65
HSPA8	interacts_with	gene	0.60
GPX4	biomarker_for	gene	0.60
IL1B	activates	gene	0.60
PVALB	expressed_in	gene	0.60
TAU	activates	gene	0.60
Rb	therapeutic_target	protein	0.60
IL1B	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
Ferroptosis	biomarker_for	pathway	0.60
INFLAMMATION	activates	gene	0.60
ERK	activates	gene	0.60
Erk Signaling	activates	pathway	0.60
Mapk	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
MICROGLIA	activates	gene	0.60
Astrocyte	activates	cell_type	0.60
Oligodendrocyte	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
Microglia	activates	cell_type	0.60
Interneuron	expressed_in	cell_type	0.60
AND	expressed_in	gene	0.60
Oxidative Stress	contributes_to	pathway	0.60
Angiogenesis	contributes_to	pathway	0.60
AND	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
Amyloid	expressed_in	pathway	0.60
Aβ	expressed_in	protein	0.60
Fus	expressed_in	protein	0.60
epigenetic regulation	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (17)

Source	Relation	Type	Str
ENO1	interacts_with	gene	0.60
DNAJA1	biomarker_for	gene	0.60
HSPA1A	interacts_with	gene	0.60
TAU	activates	gene	0.60
FERROPTOSIS	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
MITOCHONDRIAL DYSFUNCTION	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
HO-1	contributes_to	gene	0.60
TAU	inhibits	protein	0.50
IL1B	activates	gene	0.50
ALZHEIMER	inhibits	gene	0.50
AMYLOID	inhibits	gene	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FLT1

Understanding Entity Pages

Summary

Wiki Pages (16)

FLT1 Gene

VEGF/Angiogenesis Pathway in Neurodegeneration

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

Hypoxia Neuroprotection in Sporadic Parkinson's Disease

Neurotrophic Factor Signaling Decline in Neurodegeneration

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

KDR Gene

VEGFR1 (FLT1) Protein

ENO1 Gene

Brain Vascular Endothelial Cells

VEGFB Protein

FLT1 Protein (VEGF Receptor 1)

NRP2 Gene

VEGFB Gene

Proteins