GEPHYRIN

Understanding Entity Pages

This page aggregates everything SciDEX knows about GEPHYRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Gephyrin is a crucial scaffolding protein that clusters GABA-A and glycine receptors at inhibitory synapses, essential for inhibitory synaptic transmission and also involved in molybdenum cofactor synthesis. Associated with epilepsy, Alzheimer's disease, and Parkinson's disease.

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graph TD
    GEPHYRIN["<b>GEPHYRIN</b>"]
    Ms{"Ms"}
    GEPHYRIN -->|"inhibits"| Ms
    Depression{"Depression"}
    GEPHYRIN -->|"inhibits"| Depression
    PI3K["PI3K"]
    GEPHYRIN -->|"inhibits"| PI3K
    CYTOKINES["CYTOKINES"]
    GEPHYRIN -->|"inhibits"| CYTOKINES
    AKT["AKT"]
    GEPHYRIN -->|"inhibits"| AKT
    Synaptic_Plasticity(["Synaptic Plasticity"])
    GEPHYRIN -->|"inhibits"| Synaptic_Plasticity
    Akt(["Akt"])
    GEPHYRIN -->|"inhibits"| Akt
    Pi3K(["Pi3K"])
    GEPHYRIN -->|"inhibits"| Pi3K
    neurodegeneration["neurodegeneration"]
    GEPHYRIN -->|"implicated in"| neurodegeneration
    style GEPHYRIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0