gene

RAB9A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

151Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming
0Experiments

Summary

RAB GTPase 9A - Late endosomal trafficking and lysosomal function in neurodegeneration

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🧬 Gene Info
Gene SymbolRAB9A
AliasesRAB GTPase 9A
Functionis a member of the RAB GTPase family that functions as a molecular switch controlling intracellular membrane trafficking.
Molecular Weight23 kDa
Amino Acids201 aa
PathwaysMtor, Autophagy, Amyloid, epigenetic regulation, autophagy pathway
Ensembl IDENSG00000123595
GeneCardsRAB9A
Human Protein AtlasRAB9A
Active state (RAB9A-GTP)Membrane-associated, recruits effector proteins
Inactive state (RAB9A-GDP)Cytosolic, available for recycling to membranes
GEFsPromote GDP release and GTP binding (activation)
GAPsAccelerate GTP hydrolysis (inactivation)
GDIsExtract GDP-bound RAB from membranes
Lysosomal biogenesisDelivery of newly synthesized lysosomal enzymes
Associated DiseasesCancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsPSEN2, FYCO1, BCL2, LAMP2, GABARAP, PRESENILIN
KG Connections151 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

RAB9A

gene · 3229 words

SGSM1

gene · 1791 words

SGSM2

gene · 1743 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    RAB9A["RAB9A"] -->|"associated with"| Cancer["Cancer"]
    RAB9A["RAB9A"] -->|"associated with"| Neurodegeneration["Neurodegeneration"]
    RAB9A["RAB9A"] -->|"associated with"| Cardiovascular["Cardiovascular"]
    RAB9A["RAB9A"] -->|"associated with"| Ischemia["Ischemia"]
    RAB9A["RAB9A"] -->|"associated with"| Parkinson["Parkinson"]
    RAB9A["RAB9A"] -->|"associated with"| Ms["Ms"]
    RAB9A["RAB9A"] -->|"regulates"| Cancer["Cancer"]
    RAB9A["RAB9A"] -->|"regulates"| Cardiovascular["Cardiovascular"]
    RAB9A["RAB9A"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    RAB9A["RAB9A"] -->|"associated with"| BCL2L1["BCL2L1"]
    RAB9A["RAB9A"] -->|"associated with"| GLA["GLA"]
    RAB9A["RAB9A"] -->|"associated with"| GABARAP["GABARAP"]
    style RAB9A fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style BCL2L1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GLA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GABARAP fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (80)

TargetRelationTypeStr
Cancerassociated_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Cardiovascularassociated_withdisease0.65
Ischemiaassociated_withdisease0.65
Parkinsonassociated_withdisease0.65

Incoming (71)

SourceRelationTypeStr
ULK1associated_withgene0.60
BCL2associated_withgene0.60
GABARAPassociated_withgene0.60
PIK3C3associated_withgene0.60
MAP1LC3Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found