Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB9A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB GTPase 9A - Late endosomal trafficking and lysosomal function in neurodegeneration
| Gene Symbol | RAB9A |
| Aliases | RAB GTPase 9A |
| Function | is a member of the RAB GTPase family that functions as a molecular switch controlling intracellular membrane trafficking. |
| Molecular Weight | 23 kDa |
| Amino Acids | 201 aa |
| Pathways | Mtor, Autophagy, Amyloid, epigenetic regulation, autophagy pathway |
| Ensembl ID | ENSG00000123595 |
| GeneCards | RAB9A |
| Human Protein Atlas | RAB9A |
| Active state (RAB9A-GTP) | Membrane-associated, recruits effector proteins |
| Inactive state (RAB9A-GDP) | Cytosolic, available for recycling to membranes |
| GEFs | Promote GDP release and GTP binding (activation) |
| GAPs | Accelerate GTP hydrolysis (inactivation) |
| GDIs | Extract GDP-bound RAB from membranes |
| Lysosomal biogenesis | Delivery of newly synthesized lysosomal enzymes |
| Associated Diseases | Cancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | PSEN2, FYCO1, BCL2, LAMP2, GABARAP, PRESENILIN |
| KG Connections | 151 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
RAB9A["RAB9A"] -->|"associated with"| Cancer["Cancer"]
RAB9A["RAB9A"] -->|"associated with"| Neurodegeneration["Neurodegeneration"]
RAB9A["RAB9A"] -->|"associated with"| Cardiovascular["Cardiovascular"]
RAB9A["RAB9A"] -->|"associated with"| Ischemia["Ischemia"]
RAB9A["RAB9A"] -->|"associated with"| Parkinson["Parkinson"]
RAB9A["RAB9A"] -->|"associated with"| Ms["Ms"]
RAB9A["RAB9A"] -->|"regulates"| Cancer["Cancer"]
RAB9A["RAB9A"] -->|"regulates"| Cardiovascular["Cardiovascular"]
RAB9A["RAB9A"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
RAB9A["RAB9A"] -->|"associated with"| BCL2L1["BCL2L1"]
RAB9A["RAB9A"] -->|"associated with"| GLA["GLA"]
RAB9A["RAB9A"] -->|"associated with"| GABARAP["GABARAP"]
style RAB9A fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
style Ischemia fill:#ef5350,stroke:#333,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style BCL2L1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style GLA fill:#4a1a6b,stroke:#333,color:#e0e0e0
style GABARAP fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| BCL2L1 | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| ESR2 | associated_with | gene | 0.60 |
| AMBRA1 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| SOX9 | activates | entity | 0.60 |
| TFEB | activates | entity | 0.60 |
| ULK1 | activates | entity | 0.60 |
| UVRAG | activates | entity | 0.60 |
| VDAC2 | activates | entity | 0.60 |
| WDR45 | activates | entity | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| ATP6AP2 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ULK1 | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| AMBRA1 | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| ESR2 | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| AMBRA1 | activates | entity | 0.60 |
| APP | activates | entity | 0.60 |
| BCL2L1 | activates | entity | 0.60 |
| BECN1 | activates | entity | 0.60 |
| CTSD | activates | entity | 0.60 |
| ESR1 | activates | entity | 0.60 |
| ESR2 | activates | entity | 0.60 |
| FYCO1 | activates | entity | 0.60 |
| GABARAP | activates | entity | 0.60 |
| GLA | activates | entity | 0.60 |
| HDAC6 | activates | entity | 0.60 |
| LAMP2 | activates | entity | 0.60 |
| MAP1LC3B | activates | entity | 0.60 |
| MTOR | activates | entity | 0.60 |
| PIK3C3 | activates | entity | 0.60 |
| PSEN1 | activates | entity | 0.60 |
| PSEN2 | activates | entity | 0.60 |
| AR | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||