Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about semaglutide: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
semaglutide is a therapeutic compound targeting neurodegeneration research. Key relationships include: treats, associated with, causes. Associated with Alzheimer's disease, Type 2 Diabetes Mellitus, acute kidney injury. Connected to 10 entities in the SciDEX knowledge graph.
| Name | semaglutide |
| Key Genes/Proteins | SIRT1, AMPK |
| Related Diseases | Type 2 Diabetes Mellitus, polycystic ovary syndrome, acute pancreatitis, medullary thyroid carcinoma, acute kidney injury |
| Related Pathways | inflammation |
Knowledge base pages for this entity
graph TD
semaglutide["<b>semaglutide</b>"]
Type_2_Diabetes_Mellitus{"Type 2 Diabetes Mellitus"}
semaglutide -->|"treats"| Type_2_Diabetes_Mellitus
glycemic_control(["glycemic control"])
semaglutide -->|"regulates"| glycemic_control
Alzheimer_s_disease{"Alzheimer's disease"}
semaglutide -->|"treats"| Alzheimer_s_disease
neuroinflammation(["neuroinflammation"])
semaglutide -->|"inhibits"| neuroinflammation
polycystic_ovary_syndrome{"polycystic ovary syndrome"}
semaglutide -->|"treats"| polycystic_ovary_syndrome
acute_pancreatitis{"acute pancreatitis"}
semaglutide -->|"causes"| acute_pancreatitis
medullary_thyroid_carcinoma{"medullary thyroid carcinoma"}
semaglutide -->|"associated with"| medullary_thyroid_carcinoma
acute_kidney_injury{"acute kidney injury"}
semaglutide -->|"causes"| acute_kidney_injury
medullary_thyroid_carcinoma -->|"associated with"| semaglutide
multiple_endocrine_neoplasia_syndrome_ty{"multiple endocrine neoplasia syndrome type 2"}
multiple_endocrine_neoplasia_syndrome_ty -->|"associated with"| semaglutide
style semaglutide fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Type 2 Diabetes Mellitus | treats | disease | 0.70 |
| glycemic control | regulates | process | 0.70 |
| neuroinflammation | inhibits | process | 0.70 |
| polycystic ovary syndrome | treats | disease | 0.70 |
| acute pancreatitis | causes | disease | 0.70 |
| medullary thyroid carcinoma | associated_with | disease | 0.70 |
| acute kidney injury | causes | disease | 0.70 |
| Alzheimer's disease | treats | disease | 0.70 |
| SIRT1 | protects_against | gene | 0.50 |
| inflammation | protects_against | pathway | 0.50 |
| AMPK | protects_against | protein | 0.50 |
| Insulin Resistance | inhibits | disease | 0.50 |
| INSULIN | inhibits | concept | 0.50 |
| NF-κB | protects_against | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| medullary thyroid carcinoma | associated_with | disease | 0.70 |
| multiple endocrine neoplasia syndrome type 2 | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||